ID   A0A0B2VHF4_TOXCA        Unreviewed;       978 AA.
AC   A0A0B2VHF4;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Macoilin-2 {ECO:0000313|EMBL:KHN80400.1};
GN   Name=tmem57b {ECO:0000313|EMBL:KHN80400.1};
GN   ORFNames=Tcan_09693 {ECO:0000313|EMBL:KHN80400.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN80400.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN80400.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN80400.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC       {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004232}. Rough endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004269}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004269}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN80400.1}.
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DR   EMBL; JPKZ01001747; KHN80400.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2VHF4; -.
DR   STRING; 6265.A0A0B2VHF4; -.
DR   OMA; DSKIHEM; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0023041; P:neuronal signal transduction; IEA:InterPro.
DR   InterPro; IPR019130; Macoilin.
DR   PANTHER; PTHR13289:SF6; MACOILIN; 1.
DR   PANTHER; PTHR13289; PROTEIN PHOSPHATASE 1-BINDING PROTEIN BIFOCAL; 1.
DR   Pfam; PF09726; Macoilin; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        44..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        81..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        106..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          339..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          449..529
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          832..852
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..387
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        463..491
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        502..529
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   978 AA;  105833 MW;  91E9EA456DC19782 CRC64;
     MMKRSTRSID VPKLRRNMKN RSRIAETMCC GYLSGFAYVK LLVLWLVCIA LDLLIGFRFE
     LLYPVWLLIR NCYDSFRFQG LVSSLQYSAF SAFFVCATAT TDLICFVLLP VQLLLFLAST
     YVWVQFVWHT AERGVGSTQV LLWVALVSFE YNCRYRGDSP LYLLRGTTFA WTLNVITGGV
     LSSWLGLRDS RSSGAVSASE PGSSSGGTVS GRECGSRAFS SSSSVLSGFG VALTAAFAHS
     SSLTSDLCRP FAAHCIGYPV VTLGFGLKTY MSLWRFKRRQ REVSRENEVY GRLLAEALPS
     IYEGPKVYPR CNGTTIQDQE SAIDYETELL PSLAICASPS SSSSGLGAQR KSSRVGSSWK
     QNGCKQLNAK RIPSHSNGSL LSSRKDHTSQ NANDDDDTAS TASVSGTSRM SLWRVAWDVM
     LMAFSLLTGA GGESASSSLD DRISLSSNEI ESEEEMMEQE ETSSQPDDLP IPSSRLLSQQ
     RSNNTKKSKG SCTRMKGGRT RARNMHSQSE YVLGSVPSGT PSLSSPPSLG ASCALSNNLL
     NLTAGSTAHD KQLYSSSSAL SPTSNYQNSA GTALASSIFV GATQPPAPIT NKVGDDYVTL
     EELEALKGEL RAARVQETDL RCLLQQAINA EKQAKGELAQ LKMKQEQTDN KLSNLMKARE
     QDKCSMQLLE KRLIEAHAKK NELEKELNAE RRSKLKEEHA AARALAAAQS VKSVDCGEAC
     KARKADLERE IRATRRDLKA KEELTSVYEE QLRQLREFKE SNEVQELQST LAALRDKNHH
     LEQSLSAENR LKQDLFRVLT ETRSQTEMLQ QQLQAKDIEL MELRQRLSNE TNDACKMSPT
     GNSRGTVQAL SSSSGVRCGG PAGGGSLLSP VVNGVGGAMK MSTSVSTEQN MELLTAALSN
     AASNAYLPYS FGAHSGGSDH LLFDATVSAG GPGVNAPSSA PASAINSAAA ASGDSLRFSS
     AGKFGVPAAP NSTSVRST
//