ID   A0A0B2VLB4_TOXCA        Unreviewed;       587 AA.
AC   A0A0B2VLB4;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Methyltransferase-like protein 13 {ECO:0000313|EMBL:KHN82179.1};
GN   ORFNames=Tcan_14448 {ECO:0000313|EMBL:KHN82179.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN82179.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN82179.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN82179.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC       {ECO:0000256|ARBA:ARBA00007867}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN82179.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JPKZ01001397; KHN82179.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2VLB4; -.
DR   STRING; 6265.A0A0B2VLB4; -.
DR   OMA; GKMKVYH; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd02440; AdoMet_MTases; 2.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR030374; PABS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR12176; SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN; 1.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   Pfam; PF01564; Spermine_synth; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR   PROSITE; PS51006; PABS_2; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:KHN82179.1};
KW   Polyamine biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00354};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU00354}.
FT   DOMAIN          395..562
FT                   /note="PABS"
FT                   /evidence="ECO:0000259|PROSITE:PS51006"
FT   ACT_SITE        473
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00354"
SQ   SEQUENCE   587 AA;  66131 MW;  A5DD92F40E63E516 CRC64;
     MALLPYSAES FASPKFWERF YRRRVTPFEW YGDFSSLGPT LERYLKSNDR ILQIGCGNSK
     LGTELYDNGY RNVWNIDTDE GAIKKQMVDN CDGRPGLEFR CASAQQLPFE DESMSVILDK
     GVLDAILPPE QVDKDEVEEH ADVVAMFNEI FELAKSLEGK PERFDDISGL HNGVAAMQEF
     ACFCHACETW LEHEINITMM DINGKPRYQI WIVDDPDKKS FTSYASFIVP LGREYEWMYS
     TEKGRLALRR ECGKSRLAIV LFFREQIYES LTAVQGELSE LILSFAPPSL RDHPIEFLSL
     GEVNVLKTRE CGNSKISGKW TVEDVEVGGV RYRRLVFLSS SSVVQSEAKL IKSKKRKWVV
     DLDTLTCDHH EAMLTAFAFL PQRNLLDSSR GAQLKVAVLG LGGGLLASFL YRHFPTGTIV
     AVELDPDVVQ IALRWFSLPD SDGRFTVLVQ DALRFLNDMK GKAVIPFDII FLDLAAADHE
     PGLSCPPREF LTSTALNAMY DILNANGVLA LNLVARDDEI LIASKNAVRS VFPRIYVHLS
     EEDVNQVLIC PKGEVSLEQA LDGIRVNKNQ SWLTQLVTDL SSLTLDH
//