ID   A0A0B2VM98_TOXCA        Unreviewed;       756 AA.
AC   A0A0B2VM98;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Prestin {ECO:0000313|EMBL:KHN82708.1};
GN   Name=Slc26a5 {ECO:0000313|EMBL:KHN82708.1};
GN   ORFNames=Tcan_16547 {ECO:0000313|EMBL:KHN82708.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN82708.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN82708.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN82708.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN82708.1}.
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DR   EMBL; JPKZ01001313; KHN82708.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2VM98; -.
DR   STRING; 6265.A0A0B2VM98; -.
DR   OMA; CAEYFRE; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF257; ANION TRANSPORTER SULP-7D; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        111..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        144..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        197..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        276..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        306..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        358..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        438..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        489..521
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          548..736
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   756 AA;  83899 MW;  E1B528C1EFEE3E61 CRC64;
     MEAVKNSGDQ NPSGQQPRPE SSYYDKVAKN QAIFDEEFGL FTKSRHSTTK QTIAARVIDG
     FKIRPSNFID AVLDFIPILR WLPKYNIRQN LVHDIVGGLT VGIMNVPQGM AYASLAGLSP
     VNGLYTSFFP AIVYMIFGTS RHNSLGVFAV VSLMVGSANI RLTRLLNDVS ETVDNSNLTS
     LLDASDFVSQ ETRPIDIVTA LTLCVGLIQL TMALLRLDFL TGYMSDQVIK GFTTGAAVHV
     FVAQLNKIFG ISLPRYSGFG RLFRMAHDLV VQLPNANIAT TITSIVTIIL LYICKNQIAP
     RLKKFTKIPL PFDLFAILIG TLLSYMLNME SKFKMNVVGE IPLGLPAPSL PKFHLLPYVF
     GDAVAIAIIV LAVTVSMGSL FATKHGYTID VRQEFYAMGI TECVTSLFPC FTSSTALIRS
     VIYEAAGTKT QLATVFSSLL MLLVIFVLGT FVSVLPVCFL SCIILVALQR MFTQLSDLSH
     LWPISKVDFA IWLFTFIATV VYDVIQGLVI GIVFALFMII FRTQRLEVTK LGRMSHLEGS
     VYYRPLQRYR DASYVENVCC AHFGGPLVYF NVAIFKQKCF DLLRPSSQHH LLSNLRKSDS
     SESVTAGQKI EPFCHVNLEA HQKTYKRNVS NATVRSIRLD ANVDDDQKKI LTLDSFKGPS
     EVKYIVLDLS SVSFIDVMGS TALKDVYQEM KQRGILLLYS GAQLSLLEFI KRCEFDDALP
     LDGAFYPSME DAVHAISLFK GYAAERCQPD ALSATK
//