ID   A0A0B2VMU0_TOXCA        Unreviewed;       500 AA.
AC   A0A0B2VMU0;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Small conductance calcium-activated potassium channel protein {ECO:0000313|EMBL:KHN82737.1};
GN   Name=SK {ECO:0000313|EMBL:KHN82737.1};
GN   ORFNames=Tcan_18869 {ECO:0000313|EMBL:KHN82737.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN82737.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN82737.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN82737.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN82737.1}.
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DR   EMBL; JPKZ01001311; KHN82737.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2VMU0; -.
DR   STRING; 6265.A0A0B2VMU0; -.
DR   OMA; TICLICC; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR   GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 2.
DR   InterPro; IPR004178; CaM-bd_dom.
DR   InterPro; IPR036122; CaM-bd_dom_sf.
DR   InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR10153:SF34; CAMBD DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR   Pfam; PF02888; CaMBD; 1.
DR   Pfam; PF07885; Ion_trans_2; 1.
DR   Pfam; PF03530; SK_channel; 2.
DR   SMART; SM01053; CaMBD; 1.
DR   SUPFAM; SSF81327; Small-conductance potassium channel; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000313|EMBL:KHN82737.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        63..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        96..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        145..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        180..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        241..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        272..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          340..416
FT                   /note="Calmodulin-binding"
FT                   /evidence="ECO:0000259|SMART:SM01053"
SQ   SEQUENCE   500 AA;  56691 MW;  BD1EFACD8BE19B31 CRC64;
     MPDELGSDST AKMRCRMRKQ LFIKRNKVCD LSLALALAGL IFVVVDAELT ALSTDTNITK
     RHPISLLLRS LCLISTIALM ASLVNYHAIE RHPISLLLRS LCLISTIALM ASLVNYHAIE
     VKIALIDSGA DDWRVALTTE RLIKLAIELL ICAICPLPGT GMMSWPFIHP ENRKVTMVDV
     PVDVILSVPM FLRSYLLCRF MVLHSKQFQD AATRSIAALN RISMDFRFVI KTMMADHPLR
     VLIVFTVSYW ICMSWMFTQC ERYDGRVPAE HYYLNSMWFI MVTFMSIGYG DIVPNTYCGR
     TLSITTGIVG AGVSSALIAV ISRKLELSRA EKHVNNFMAD SKLTNQRKNA AASVLQETWF
     IHKYKMSCTK GDDLRLRQHQ RRFLHAINEF RRIKWDQRKL QEKGNSLLDV GKLHNEMHET
     LWEMHRTQDQ FIAQVDLLTQ KIVELQNTLL MQQQRGYLPA PNAACLPLTQ STSSSALLHI
     PVPHGSTVAQ FDSSNLPPCP
//