ID A0A0B2VNU4_TOXCA Unreviewed; 1515 AA.
AC A0A0B2VNU4;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 2 {ECO:0000256|ARBA:ARBA00020977};
DE AltName: Full=Component of oligomeric Golgi complex 2 {ECO:0000256|ARBA:ARBA00031344};
DE AltName: Full=E3 UFM1-protein ligase 1 homolog {ECO:0000256|ARBA:ARBA00014160};
DE AltName: Full=E3 UFM1-protein transferase 1 homolog {ECO:0000256|ARBA:ARBA00030452};
GN Name=cogc-2 {ECO:0000313|EMBL:KHN85186.1};
GN ORFNames=Tcan_04139 {ECO:0000313|EMBL:KHN85186.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN85186.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN85186.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN85186.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: E3 UFM1-protein ligase that mediates ufmylation of target
CC proteins. {ECO:0000256|ARBA:ARBA00003950}.
CC -!- SIMILARITY: Belongs to the UFL1 family.
CC {ECO:0000256|ARBA:ARBA00010789}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN85186.1}.
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DR EMBL; JPKZ01000843; KHN85186.1; -; Genomic_DNA.
DR STRING; 6265.A0A0B2VNU4; -.
DR OMA; SQNAETM; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0071569; P:protein ufmylation; IEA:InterPro.
DR InterPro; IPR024603; COG_complex_COG2_C.
DR InterPro; IPR024602; COG_su2_N.
DR InterPro; IPR018611; Ufl1.
DR PANTHER; PTHR31057; E3 UFM1-PROTEIN LIGASE 1; 1.
DR PANTHER; PTHR31057:SF0; E3 UFM1-PROTEIN LIGASE 1; 1.
DR Pfam; PF06148; COG2; 1.
DR Pfam; PF12022; COG2_C; 1.
DR Pfam; PF09743; E3_UFM1_ligase; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 33..161
FT /note="Conserved oligomeric Golgi complex subunit 2 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF06148"
FT DOMAIN 360..670
FT /note="COG complex component COG2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12022"
FT REGION 1080..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1515 AA; 169415 MW; 5D777B946E4ACFD4 CRC64;
MMAAPAASSK DTAASVSHAL FSSTSNPLND SHLCFNKAHF SRTDFNVERF LSLARRRANL
AQIHNDLRVY LKVVQNSMIE LINDDYADFV NLSSNLVGLK ETIDKLNKDI EVIWDDLCGS
TRDVMVTAEY IDQQANDLAE CRAAQVDLSS KISLIMAIER LADKIASKPD SIDSFWLDGL
SDAVVDMELW YRKTLKPDSE LGDARKACLL RVQNMIEAWL VSDLQGDCTS VEALLGILTL
IEGLDSALSR VMTEVIDPRV EKHTNDLGLF LDSLLAKMKE LREEWLSKLT KNASRLLTIS
PFLDKSLLTY IVSVLDLHFG SVLVPSDNRL FHRCYMAVCE FLSSWPGASN SRTVLRMIRD
RFNLIVYFKL ETHQLFADLC DQLNPRAFRF VTTTSPNDRD ISEKRNGGSS LILLEPEEKL
YCECSAVTIR ALMSVWNDDV YLPTLLDKLW DFSIKVLAKY SDWLDALLKY FGSDGSTIEG
IDTWRALCAV YVDCSTVDGR VFEIALSYIW AKIREYGLDV TPFGQCLSAF SSRIAKKRKE
FEDIIVRHIV ASLSKVMDGV SDIPRHYRWT KKPQPTEPSL YINEAFSVFD SFKKEVHGRC
WSDEDVENVS KRILADSLNA FCDKAEQVLD SVEQTGSSLQ RFKRKSAAGS ADVSTADTDE
GKIRSQLTLD LTLCRSQACA LEIDVPRIDK LIARADSTTD GGMKTGPILS LPDMAAVAEI
HVKMTTTWAD IQRLAADLQR VQLAEGAKKL SEKNCVEVVS MLMASKAIDI VFTSDGHAYL
TKKHLLTEIK NECIGRGGRV SLSELAHTLN VDYEHIENSV AIILKQSSSF VLCNAELVSR
DYVDLLCKEL NERLSETGVL SISQLAKSWD LPSEILNGLV LIEIGNKVDA MRDGDAIYTR
AYLSAQSRLL RAMLIALTKV TPVAKLTARL NLSPSIFWSL YDELVDANEV PGTVVGGRSS
NLAYYVPNIY KILVRSFVLK SFEQQKMIET SVLKKLFVTD ASVYMKDVLP KTEYASLVFF
PSAVVSNKLW EEIELSIKND VREWMSVSGQ PFIYTAQLLS NALKAVDGLI NDRAENEAQN
LGKQQKIMKK QEKPQDEEWA AVKGKKGRGG KGKGGKQAPK EESAPTSSYR IPREELINEL
ERVSTIPPEL LDEVAEQISQ NAETMLRTRI EALLRTVQTI SAQDQKRAHL QLQEKLRALY
NNASYRIPRE ELINELERVS TIPPELLDEV AEQISQNAET MLRTRIEALL RTVQTISAQD
QKRAHLQLQE KLRALYNNIC IFEQATNSFD ESVATDLRSY LIRTLCTDVA NIVLSFVSGT
ENVNTLSPKI REETISGIEN AESREAVALL FSSLSNADLD AFHSAISDIS SPAVCSLNLR
MPDKKQRAEL VEAYAAELEH QLRVCEDPAA GLLIALLVIL ARRYSIAVHA SGKFVSHLIL
KVEKVVDCSS ELNELLTSMQ KLVVAVMKNK SNVEMKTKLN EKLKSMKILL LGAEVVEESS
KDGGVEDGEL VEVKS
//
