ID   A0A0B2VQ44_TOXCA        Unreviewed;      1122 AA.
AC   A0A0B2VQ44;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   22-FEB-2023, entry version 25.
DE   SubName: Full=Nonsense-mediated mRNA decay protein 2 {ECO:0000313|EMBL:KHN85646.1};
GN   Name=NMD2 {ECO:0000313|EMBL:KHN85646.1};
GN   ORFNames=Tcan_14565 {ECO:0000313|EMBL:KHN85646.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN85646.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN85646.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN85646.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN85646.1}.
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DR   EMBL; JPKZ01000751; KHN85646.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2VQ44; -.
DR   STRING; 6265.A0A0B2VQ44; -.
DR   OMA; IWPDEDT; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   Gene3D; 1.25.40.180; -; 3.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   InterPro; IPR039762; Nmd2/UPF2.
DR   InterPro; IPR007193; Upf2/Nmd2_C.
DR   PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR   PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR   Pfam; PF02854; MIF4G; 2.
DR   Pfam; PF04050; Upf2; 1.
DR   SMART; SM00543; MIF4G; 3.
DR   SUPFAM; SSF48371; ARM repeat; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036}.
FT   DOMAIN          44..250
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   DOMAIN          425..613
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   DOMAIN          627..835
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   REGION          861..910
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          264..291
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1122 AA;  128064 MW;  9AF92192BBEC77B8 CRC64;
     MSKPVEAYVA EVEQRAGAQL ASRERLRSAT PLSEEQLRKM DSTLKRTTAF MKKLKNIGSA
     QQTAILADLD KVNLSKFVEE MARCIVDAKI KLSDVQSVVT ICVQLSSLYA EFPLLLLTEL
     KKILPTKRLD KIANPSKLRL DLRLLSELCL HGVFAKEGIH LLGSTVSYLT LTDKSDHFNV
     PILLSLCKAL GPDIFGLYPY SIQQEASETG TELKQVDVML PEQKKVFAHL LLDYRKTLIE
     HVSKELCEMN RLLRSIKRQT RTRGDASADE RARLEETRQR YEKQLHNAVH LSDALGVEME
     NMVEEQSEDE EEEMSAMEMG RALQQGTLSI WPDEDTRQFY ETRMELRQLV PAILFQESEQ
     RTLEPVCAAI EDVDVTGLED IAEVNEDEQL QSEEDEEEES ELDVCEVVQV DAPKASGQEL
     KLMMNAFLEQ LPWLINRDLI DKAALDFVTN FNTKNNRKKL CQVMLEQHRD RLDLLPFYAR
     LVATLEPVMP DLALELSHAL IQQFRVTVQN RSKLRVDWKV RCCRFISELV KFGVVPKAEA
     LSCLRMALFD FRGHNVDMCC AMVDSMGPFL YRSTDSHGKM KILLEVMMKK RDHINDPRQQ
     MLIDNAYYTC IPPENAQSTI SARPPLHDFI RHLVVSLTRF RVEVTVRCLR KIDWSDPEIA
     EYAVHCLSNP SLPKFGNIAY LASVIAILTS YHDWIGVSVL DNVLEEIRLV LEFNHPSLNQ
     NAVLAVAFLG HLYNYSVCDS PIIFKTLYQL ITYGALDVHL DDWNNLTRVR LVCELLLICG
     EYFNGGSARK KLDCFLAYFY RYLWAKKDAY AARETPFPNE VTFRIEEMCE YVRKGSHVPE
     SMQEAQQLVD EVEKQYRYAV ESKMSREERG DPETDEEEEE EDPGRIEANR QLDPIGEEDF
     SSSEEAGTSS FFDDVENVRV HTNHVVLPED EQFVRQLDLM VQEAMQERTK EGAGRILCAE
     GQEFGGEEAG TSSFFDDVEN VRVHTNHVVL PEDEQFVRQL DLMVQEAMQS RPSTTSAPIT
     EISVPTSARQ KFHRSIAFAD TASNPSRNAG NAGESLDTTR MAILTRAKGN KTVLKAIAME
     APSGLADAWS AERERERREH SEHKHITLTI NERMMADEQN CD
//