ID   A0A0B2VRJ7_TOXCA        Unreviewed;       351 AA.
AC   A0A0B2VRJ7;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Protein gooseberry {ECO:0000313|EMBL:KHN83949.1};
GN   Name=gsb {ECO:0000313|EMBL:KHN83949.1};
GN   ORFNames=Tcan_15563 {ECO:0000313|EMBL:KHN83949.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN83949.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN83949.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN83949.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family.
CC       {ECO:0000256|ARBA:ARBA00005733}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN83949.1}.
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DR   EMBL; JPKZ01001120; KHN83949.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2VRJ7; -.
DR   STRING; 6265.A0A0B2VRJ7; -.
DR   OMA; RYYRTGI; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR001523; Paired_dom.
DR   InterPro; IPR043565; PAX_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45636; PAIRED BOX PROTEIN PAX-6-RELATED-RELATED; 1.
DR   PANTHER; PTHR45636:SF38; PROTEIN GOOSEBERRY-RELATED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00292; PAX; 1.
DR   PRINTS; PR00027; PAIREDBOX.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00351; PAX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 2.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS51057; PAIRED_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682};
KW   Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
KW   ECO:0000256|RuleBase:RU000682}; Paired box {ECO:0000256|ARBA:ARBA00022724};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          14..141
FT                   /note="Paired"
FT                   /evidence="ECO:0000259|PROSITE:PS51057"
FT   DOMAIN          228..288
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        230..289
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          137..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          195..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  39406 MW;  FC96A00998D97A92 CRC64;
     MNDTKAISFT NIMGQGRVNQ LGGVFINGRP LPQHIRLKII EMASNGIKPC HISRQLRVSH
     GAVSKILNRY AETGSISPGQ IGGNPRSRLA IQAVEKHILA LKAEKPTICA SELRARLIEQ
     EVCSRENAPT VSSINRHIRA KRLHSPPAKR EKKSKLNHSI ENILGISIGL HGLKRATIMP
     LKRALGENKQ TKCIDRNADE RKLESPETSS SDEESSIRAD DESEPMTKKA RRNRTSFTCE
     QLDVLENAFR ANTYPDQEER ERIAATTRLS EEKIMTWFSN RRARCRKNLS ISSAHPFIMH
     SLTPQTTVPV AQPPLVTMFS QPIGFFPPTV SPQSLKLHEQ PIIYYPQYTA I
//