ID A0A0B2VRY5_TOXCA Unreviewed; 1185 AA.
AC A0A0B2VRY5;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Myosin heavy chain, non-muscle {ECO:0000313|EMBL:KHN84458.1};
GN Name=zip {ECO:0000313|EMBL:KHN84458.1};
GN ORFNames=Tcan_08393 {ECO:0000313|EMBL:KHN84458.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN84458.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN84458.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN84458.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC {ECO:0000256|ARBA:ARBA00004657}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN84458.1}.
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DR EMBL; JPKZ01000986; KHN84458.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VRY5; -.
DR STRING; 6265.A0A0B2VRY5; -.
DR OMA; VYMMNPP; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 2.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF71; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Thick filament {ECO:0000256|ARBA:ARBA00022433}.
FT DOMAIN 29..79
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 83..784
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 662..684
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 848..1162
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 176..183
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1185 AA; 137553 MW; 13FD341973A1D2BA CRC64;
MANSATSEIS YLQVQKGIVA DPALQAEWSK KRLVWVPHET EGFVAGVLKE DRGDDVVIEI
AETGKKLTLS KDDVQKMNPP KFDKVEDMAE LTCLNEASVL HNLKERYFSS LIYTYSGLFC
VVVNPYKKLP IYSEALIEAF KGKKRHEMPP HIFAIADTAY RSMLQEREDQ SILCTGESGA
GKTENTKKVI QYLAYVAGAT RQSKTPSSPA KPRHDLENVI GELEHQLLQA NPILEAFGNS
KTVKNDNSSR FGKFIRINFD MSGYISGANI EFYLLEKSRT LRQAADERSF HIFYQFLRGT
SPTEKANFLL EEVDKYRFLN NGYICLPNVD DATEFHNTIR SMKIMGFHDD EITSVLRLVS
AVLLFGNMEF FQEKKSDQAI LPDDRVAQKL CHLLGLPLVE FTKAFLRPRI KVGREFVHKA
QNKEQAEFAV EAIAKACYEK MFRWLVARLN KSLDRTRRQG ASFIGILDIA GFEIFELNSF
EQLCINYTNE KLQQLFNNTM FILEQEEYQR EGIDWKFIDF GLDLQPTIDL IEKPMGILAL
LDEQCLFPKA TDKSLVEKLL VNHAKHPKFV IPEMRAKSDF AVIHYAGRVD YSADQWLMKN
MDPLNENVVA LFQNSSDPFV VSIWKDAEFA GICASELNET AFGVRTKKGM FRTVSQMHKE
QLTRLMTTLR NTNPHFVRCI IPNHEKKAGK ITSMLVLEQL RCNGVLEGIR ICRQGFPNRV
PFQEFRHRYE ILTPNVIPKG FMDGKEAVRK MIDALELESN LYRVGQSKIF FRAGVLAHLE
EERDLKLTDL IVSFQAQCRA FLARRLYQKR VQQSNAIRVL QRNGLAWLKL RNWQWWRLFT
KVKPLLQVTN QEAAIAAKDE ELKVVKEKLS KREVEYSEIE KRIQQLSEER AVLQEQLQQE
SEERAEADEL RERLTARKVE LEDMLTELNT KLDEGEEQME KLSEEKKKLQ ETVRDLEEQL
EEEEQARQKL MLDKVNVDQK WKKLEEKHAE LYDSYEKLVK EKKNLEERTA QLSNQLLEEE
EKAKHVGKQR SRVEVALHEM EQELQKEKQA KTELDRQRRK LEAEMEEQKE LLEEKRSKLE
ELNALLSKRE EELTVLLTKS DEDSANNVVL QKQIRELEST LEELKEDLEN EKSLRAKAEK
SRRDLNDDLE TLRTEYLEAT DKTAVSLEIQ KKKDEELKEL KVITS
//
