ID A0A0B2VTZ2_TOXCA Unreviewed; 1421 AA.
AC A0A0B2VTZ2;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Protein diaphanous-like protein 1 {ECO:0000313|EMBL:KHN84802.1};
GN Name=DIAPH1 {ECO:0000313|EMBL:KHN84802.1};
GN ORFNames=Tcan_03805 {ECO:0000313|EMBL:KHN84802.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN84802.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN84802.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN84802.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN84802.1}.
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DR EMBL; JPKZ01000899; KHN84802.1; -; Genomic_DNA.
DR STRING; 6265.A0A0B2VTZ2; -.
DR OMA; FHHCIES; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF6; PROTEIN DIAPHANOUS; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036}.
FT DOMAIN 253..653
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 855..1278
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 290..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1389..1421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..832
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1421 AA; 159187 MW; C4897F7A939BA7EB CRC64;
MESEVDSFRK TSLALSSERL FDDPEEHAFV DHPVRPWRRS KSVCASSPFA YVSPSDLSGR
LPLKNSTDTV NKASVTGMEK QDGARVTFNA DCTDYETSAH RLRTSDIQTS VSPFAPPLKR
SGRTADFRRT SFANLSRYFD RAAKSVNADE DWSRLLKPIE APRFARHIWR ERLSEEGGEK
VVRDVNGPSL KRHNSDIWGR RSGMTQLSRK SSYAMGKLSD AFQYKTKYFT PTEPSCASHP
QTSRASIADL EPVGRMSDEQ VNDAFRELLK QMNIKGEKLE ALLADRDMEK KRRMVSQSQR
LNMSGRDASK SPMDFVHRME RVVQAGDGHM NMLRDLLKDL KVHLSVQKVD YIKEFGDQGG
IQLLFRIMES LIDMLRQTDC PERDEEGASL LHDSVKCLKA IVNTWPGMYL CFKRDSKMFA
CLVGALSVAA SKPTLDHWYS LRFETLNLLT VVAFINDDQF EVQGRDVLLE ELTKEGQRTK
CERFWCIVSC LKKTNRLDVV KKALMLVNII LDVRDPEDTS TDEGKAAAEE AWQMRMHWRS
EFMRAGMYHC VDFLEHCTAE AIKAQYDTFC HNKEADFTEL VCRFEQIKSE YDRVDDCITL
LLSSIRGTKA ENSFLSILQH LLLIPDDIVV RPNYFRLIEN CVSEIVLPKT CVDPDFRGKF
EFTQDVCQIV DTYDDNDITK QFNKRIEAAT QAKNEALAKQ SQYYKKMEEF AEEAKKLRQH
IEDPKLPLPP PTSGKLPPPS IIIDAGPSLP AITGGPPPPP GLPPVTGGPP PPPPPPPLGG
LPRVTGGPPP PPPPPPPGGV PPPPPPPASG LLKSGGGPPP PPPPPGSKGP PGPCLPGVLG
GMAAASPELP DYLKKKPKRN VEVPMKKIPW TSATIKPMQI PKDSFWAQTS EEKFANERLF
ESLKMKFATS RQPLLADSSE AKGTSGKGLT KKKVKKPLVI NDDKVLQALA ILQGSCKLSL
REWRRCLLEV DEQTLDAGTM QQLRTALPPV EMLKKLKELA DKHFDEMPEG EQASCLYCPH
RALVIQAFAA TLASINALPA RLDSIVFMLR FNETLNDLKP GISAVIEACD EVRTSAGFAM
FLEMVLLVGN YMGHSSKTYK DTFAFEMSVL TKLADTKDVD NKETLLHHLV IQMGQQANGA
YAQFPTDDFM HVTKASRVNP DEIGKGVVAL KNAITKIENQ LKGYKKQADN DLFVEKLGPF
LEKAKTEYDI VDKMHQTMNS KWDSLRRYYA FDPKKYSMDA FFGDMKTFKE HYEHAYHDIE
KARELKEREE QRKKRAPFRQ LQSNLTPSSM NRGVKIDGLL KNGKEGSGVV DEIEKFLEGG
YLKNAERKTP RSVPRTRAGR AALQRQRSRC TDMLLTTAFD NSASPISGVP ATGQYKIRRK
GQPTITVKAD GTAVAPKENA NPGEEKKAPK TDDLLARLDQ L
//
