ID A0A0B2VUH6_TOXCA Unreviewed; 749 AA.
AC A0A0B2VUH6;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 08-NOV-2023, entry version 32.
DE SubName: Full=Tyrosine-protein phosphatase non-receptor type 12 {ECO:0000313|EMBL:KHN85007.1};
GN Name=PTPN12 {ECO:0000313|EMBL:KHN85007.1};
GN ORFNames=Tcan_07088 {ECO:0000313|EMBL:KHN85007.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN85007.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN85007.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN85007.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN85007.1}.
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DR EMBL; JPKZ01000884; KHN85007.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VUH6; -.
DR STRING; 6265.A0A0B2VUH6; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00047; PTPc; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46163; TYROSINE-PROTEIN PHOSPHATASE-RELATED; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Receptor {ECO:0000313|EMBL:KHN85007.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036}.
FT DOMAIN 89..341
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 277..332
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 84563 MW; 1E1CEB7DF8794C3C CRC64;
MEGGQTGLSE PRRGRSIKKN ALKTAREDST GSVTPTSTST LTETNASASA SFKKITFSRT
AKIPKEKLAE IVAMVNFAEK INAMDIDDFK RLFRQIQVRG PYPNKLTKHA HDQNSVKCRY
NDIVCLDDSR VVLKPMPKFS GDFIHASWIS HEFLAKKFIC TQGPMENTMA DFWRMIWQEH
IELIMMLCEL SEEGSEKCSP YWPINQGESM QFYGITVSNI GIQCKEEVVL TIMSITYEGE
TRKVRHFHWK GWPDRFAPRR LITPYTLHGI SHTVKWPTVV HCSAGIGRSG TFVMLEILYR
SLRAGKERSV SSLVWDLRSQ RAGAVQTFDQ FLFIYYATIQ RLINRGIVDP ASVAKFCKDY
ETRFKRKTGK VPIEWPQPTR RIIVDPALLE RARARTTTKT VRHHKKNSAQ ISHPLEDLKT
VEKLGNSKGS FEAKRHSANS KSCSEVGRKE AKSDELDAEK APKQKASLVS RSKSRTSVSE
KLLSKKEEKA ASIEPKATSA HRQKAALSPK QTATSPLQSK SCETSETGGS TETLEAALVT
SETTTKSKED TQPSKENMNG THANNGIKPF TEAELQSSKE NVLLFKEEVQ SFKQPHQSES
KDEGKNKKAQ TVTNEFLLDE FKKPANENAP KVSQDELENK SPSQNPMKQG PTQQMPEVEF
FQEAHSCDSD FVAQDMAQFN VRKKEQEPEP KKDIDIDQSP DDMKEEEFFI GKDIDIDQSP
DDMKEEEFFI GIQKAGTCNS VYLSFPPGK
//
