ID A0A0B2VXA0_TOXCA Unreviewed; 593 AA.
AC A0A0B2VXA0;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=RNA methyltransferase {ECO:0000256|RuleBase:RU367087};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU367087};
GN Name=Y17G7B.18 {ECO:0000313|EMBL:KHN86064.1};
GN ORFNames=Tcan_17810 {ECO:0000313|EMBL:KHN86064.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN86064.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN86064.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN86064.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361, ECO:0000256|RuleBase:RU367087}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN86064.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPKZ01000646; KHN86064.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2VXA0; -.
DR STRING; 6265.A0A0B2VXA0; -.
DR OMA; TQRIGKR; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR039772; Bin3-like.
DR InterPro; IPR010675; Bin3_C.
DR InterPro; IPR024160; BIN3_SAM-bd_dom.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12315:SF0; 7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME; 1.
DR PANTHER; PTHR12315; BICOID-INTERACTING PROTEIN RELATED; 1.
DR Pfam; PF06859; Bin3; 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51515; BIN3_SAM; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU367087};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU00848};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU367087}.
FT DOMAIN 304..532
FT /note="Bin3-type SAM"
FT /evidence="ECO:0000259|PROSITE:PS51515"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 66438 MW; 92D15CE0A4307A5D CRC64;
MSDSVLDTMS SATKECAGGG SSESGITGER PKDGDVGEQQ RGKRSQRSSR GRRGGGSGAF
RRRYTGDAAS WGAKRRRCGD VGEMPFLHGG NIKDPLNLES VKPVDEAEIM KPLEVIIPKN
MHDPLNLRSI TKNRNKRKRK NSKQGECVES PTGMEDEQRR RSNTFVAFGD HRQSSDAIVS
PVPVSVVRKF SAAVAGNVQR QRGHKGDGSW KRYCEPSGTL TPASYPHVSA TATSSSALTS
QRMQEPGKPV VTVCEQPSSN AAVEQRKPVD AQEQGQKMKQ KERFRYGNFN RYYGTRLEDG
GARDPRLFVL KKEWFKKKAV LDVGCNAGYI TLSIAKDFEP RRILGIDIDE HLVGVARKNI
RHYCDNDTAM SGSFPASFAR RYGPISVHST KFSTKFPDNV WFRRENYVLD NDECLNQVCE
EFDVILALSI TKWVHLNWGD AGLKRFFRRA FLQLRPGGLF ILEPQAFDSY KKRARMTPEV
QETFKSIQFL PDAFQEFLLC EVGFESCEHL EAPKAKSKGF QRPIQVYHKQ APKFVCSAAK
TAKCLRFTEG ANNEYVQRSS EQTGHETEGS QTVHNDDRKG TSCRTNESNS ISS
//
