ID   A0A0B2VYR8_TOXCA        Unreviewed;       758 AA.
AC   A0A0B2VYR8;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Translation initiation factor IF-2, mitochondrial {ECO:0000313|EMBL:KHN86482.1};
GN   Name=Mtif2 {ECO:0000313|EMBL:KHN86482.1};
GN   ORFNames=Tcan_13773 {ECO:0000313|EMBL:KHN86482.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN86482.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN86482.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN86482.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00007733}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN86482.1}.
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DR   EMBL; JPKZ01000617; KHN86482.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2VYR8; -.
DR   STRING; 6265.A0A0B2VYR8; -.
DR   OMA; TVECIRF; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd01887; IF2_eIF5B; 1.
DR   CDD; cd03702; IF2_mtIF2_II; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 2.
DR   Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR   InterPro; IPR044145; IF2_II.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43381:SF20; TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50447; Translation proteins; 2.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW   ECO:0000313|EMBL:KHN86482.1};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036}.
FT   DOMAIN          211..380
FT                   /note="Tr-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51722"
SQ   SEQUENCE   758 AA;  83513 MW;  02C730EFDBA78241 CRC64;
     MSCLLRSVRC ALASTPSCSA VASLTPKNFT INAVLLARHS KRKRKFVEPV VVKNTKSSKK
     PVDIYNDMTV SEVAVAVGST NDDVAELLLQ IDSRNVDLLS EDRGHGSSPH THRGIGADML
     YEYVAKGEVA VAVGSTNDDV AELLLQIDSR NVDLLSEDRV LRTDLIAQVV SAFNLRPRLV
     ARPNESKLAA KTDGTDDVFP LPPPSELDLH RRAPIITIMG HVDHGKTTLL DCLRHSRIVE
     SEFGGITQHI GAFTVKEGEQ QMTFLDTPGH AAFAGMRQRG ANSTDIVVLV VAADDGVKEQ
     TVQSINYAKE AGVPIIVAIN KCDKPNADPR KAKRSLLQYG IVVEDFHGDV LSVEISALRG
     DNIAALKEAI LLQAEDMNLR STSKGPVEGV VIESTTVQGV GKVCTVIVQR GTLTKGCVLV
     AGTSWAKVRL MTDEFNRIVK EAGPSSPIRV AGWRDSLPSP GERIIQVDSE ARAQRAVEYR
     ISKKMEQKAE LDWKAIEGDR EAERKKYLEN RQRLLDKGAR YGSTLRRLVH KEHRLEKEVS
     DGKPCLKMMI HSDVDGTLEA LLKVLETYTS QKVELQLVDF GVGPPCEKDI ELAAGTGAII
     YCFNTMIGAP IKRLADRLNV PVERFNVIYH LVDDLKSRLS ACLPDEIEHK LVAEGRVLKE
     FLISDRGRKK KPIAGVRVIW GNFTKSNIYR FQRGNTVYYE GNVESMKCEA ESVTSAKTNE
     EVGLALANKA IRFEEGDVVN VYEKIAVKQT IDWNPPGF
//