ID   A0A0B2W043_TOXCA        Unreviewed;       398 AA.
AC   A0A0B2W043;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Glycine receptor subunit alpha-3 {ECO:0000313|EMBL:KHN87002.1};
GN   Name=Glra3 {ECO:0000313|EMBL:KHN87002.1};
GN   ORFNames=Tcan_13593 {ECO:0000313|EMBL:KHN87002.1};
OS   Toxocara canis (Canine roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX   NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN87002.1, ECO:0000313|Proteomes:UP000031036};
RN   [1] {ECO:0000313|EMBL:KHN87002.1, ECO:0000313|Proteomes:UP000031036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN87002.1};
RA   Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA   von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA   Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA   Gasser R.B.;
RT   "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHN87002.1}.
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DR   EMBL; JPKZ01000489; KHN87002.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2W043; -.
DR   STRING; 6265.A0A0B2W043; -.
DR   OMA; CCRYSAL; -.
DR   Proteomes; UP000031036; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   PANTHER; PTHR18945:SF913; NEUR_CHAN_LBD DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KHN87002.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        249..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        285..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        352..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          16..197
FT                   /note="Neurotransmitter-gated ion-channel ligand-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02931"
SQ   SEQUENCE   398 AA;  45087 MW;  A9135C1C2D2BA9FB CRC64;
     MQLTQIAVNG CTNEEEVIEQ LVTRADATPP GKEEPISVAI GIRLQRMNLI SDTNSLHIDA
     FLTREWMDNR LNFDDSNACR TAINGNTLKI WLPQLTPING DAFQFHTDTN VAIVHSNGSI
     IHGQRFDGQI PCLTDALSYP FGNTTCTLIF QNEQLPQNRL QMKWSDTITR RPFATAAPIE
     QVGDLKVMHI SFLRNISAQS NGNFDKLILE IHFSRSSSKT LLLFYLPSVL IVCISWLSLV
     LGPMAITRAI MNIGAFVLLL LHYSSNMADL PRTTGITAID IWKIGTMLFV LAILFELVIV
     TCMASVGRSR RLTRCCRRLP RKKGRYSMEP LYEELNDLRQ RKTRITCSCC RYSALIVDFI
     SLNVFAATFI LFTILYFSNA EDLVLYFNDF QMGDFFID
//