ID A0A0B2W0T1_TOXCA Unreviewed; 619 AA.
AC A0A0B2W0T1;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=Slco4c1 {ECO:0000313|EMBL:KHN87593.1};
GN ORFNames=Tcan_07843 {ECO:0000313|EMBL:KHN87593.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN87593.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN87593.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN87593.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN87593.1}.
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DR EMBL; JPKZ01000401; KHN87593.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2W0T1; -.
DR STRING; 6265.A0A0B2W0T1; -.
DR OMA; EFDSHKR; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF153; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 92..108
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 120..141
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 201..222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 242..267
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 346..370
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 382..400
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 510..529
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 550..575
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 423..478
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 619 AA; 68092 MW; 06E770705B9B5D29 CRC64;
MTSNGRTKIY DCSQGDEAMK HQRPVDIPLS NFKFGYGSLK PLWLQRANRA PVLLAALCIC
AICQGSIVNG FISTSISSLE KRFSLSSTQS GIFSSFYDVA VVLVLIPLSH FGNKCHKGRV
IATGMVLVGI GSILLILPHF FAGKYSVGEQ RQTVCNSSPS EDVCLEGVTG VSAIWFYILL
ASQLLIGVGA APLFTLGIYM AMSTIGPAIG FIAGGQLLKI WGDIGKSDYR HLSISGTSDP
RWYGAWWIGF AIAGAFSLLS SIPLFGFPKE LPEKQRHRLK DVKQTHKDLD KDFGKSLADY
PKIVLTLIRN PSVMALMAMQ TSEAFLMNGF ITFIPKVFEN LFAYSASFSS TITGIIVVPM
GLFGSLFGAI LAKKTLRFQP TIALAIIFNV CALCFSFVFL HECEQKPFAG VTHDYTGAHA
NSTTFKSSCN DMCHCTTIYD PVCNPETGIS YYSPCFAGCL KQQYNDDGSP KDVWESCACV
SRHLFNSTKI PTNGNIVQKG LCRSECAQTL FFIVFACLCF FTFSSAIPIQ NASLRVVSFD
TRDVAIGLTW LFMRIFAIGM KTLIIFFLSI SYYFYKQPSD DDINEKKATS NRHEQRSDLA
LAVRQETSKT LTGVARTYG
//
