ID A0A0B2W1Q6_TOXCA Unreviewed; 462 AA.
AC A0A0B2W1Q6;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Citrate synthase {ECO:0000256|RuleBase:RU000441};
GN Name=cts-1 {ECO:0000313|EMBL:KHN87552.1};
GN ORFNames=Tcan_03222 {ECO:0000313|EMBL:KHN87552.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN87552.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN87552.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN87552.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|RuleBase:RU000441}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN87552.1}.
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DR EMBL; JPKZ01000420; KHN87552.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2W1Q6; -.
DR STRING; 6265.A0A0B2W1Q6; -.
DR OMA; VLEWLFK; -.
DR UniPathway; UPA00223; UER00717.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR GO; GO:0006101; P:citrate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR010109; Citrate_synthase_euk.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR NCBIfam; TIGR01793; cit_synth_euk; 1.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF8; CITRATE SYNTHASE, MITOCHONDRIAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000441}.
FT ACT_SITE 296
FT /evidence="ECO:0000256|PIRSR:PIRSR610109-1"
FT ACT_SITE 342
FT /evidence="ECO:0000256|PIRSR:PIRSR610109-1"
FT ACT_SITE 397
FT /evidence="ECO:0000256|PIRSR:PIRSR610109-1"
SQ SEQUENCE 462 AA; 51286 MW; 7601827BC7992AD4 CRC64;
MDEGLCERKR AIVTCVSQFS TQQSSTNLKE VLAGKIPQHV KKVAEFRKAQ GSTALQSVTV
DMIYGGMRTM KAMVTETSVL DPEEGIRFRG YSIPECQKLL PKAPGGEEPL PEGIWWLLCT
GDIPNESQTT AISQYWASHA DLPEHVEKMI RNFPSKLHPM AQFVAAIAAL SSESRFALAY
QRGVAKSTYW EYAFDDSMEL LAKLPTVAAM IYKNLYREGS AIEATDPNKD WSANFALMLG
YDDPVFAELM RLYLTIHSDH EGGNVSAHTS HLVASALADP YLSFSASMAG LAGPLHGLAN
QEVLIFLSKV AKDLGKKYTE KDLSDWVWKH LKSGQVVPGY GHAVLRKTDP RYVCQREFAL
KHLPNDEMFR LVSTLYKVTP DILLKQGKAK NPWPNVDAHS GVLLQHFGLT EMAFYTVLFG
VSRAMGCLSQ MIWSRAMGLP IERPKSHSTD GLIKLAQKAA KN
//
