ID A0A0B2W3F1_TOXCA Unreviewed; 667 AA.
AC A0A0B2W3F1;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
DE Flags: Fragment;
GN Name=ANO4 {ECO:0000313|EMBL:KHN88142.1};
GN ORFNames=Tcan_15988 {ECO:0000313|EMBL:KHN88142.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN88142.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN88142.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN88142.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN88142.1}.
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DR EMBL; JPKZ01000265; KHN88142.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2W3F1; -.
DR OMA; NATEICY; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF73; INCREASED SODIUM TOLERANCE PROTEIN 2; 1.
DR Pfam; PF04547; Anoctamin; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 81..100
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 159..183
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 203..229
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 349..372
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 400..424
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 1..298
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT DOMAIN 305..543
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 557..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KHN88142.1"
SQ SEQUENCE 667 AA; 76671 MW; 40CFE72126B113BB CRC64;
YFAWLGFYTK VLFPAAVAGV LCFLFGVLTY SQDIPSNDIC GSDGIGAVVM MCPTCDTYCS
FTPLNASCVY SKLTYIFDNN ATVLFAALMS IGATLFLEGW KRYHAEIAWK WGLLDFEVDE
ETVRPEYQLR VKEARTKRLN PITQQLEPYM PFRQRILRFF ASGITVLFFL LLVVAFVVGV
VIYRIVLLQV LYRVDGMKQY ASLVTFTTAA TLNLAVILVL SYVYTFLALK LTDWECPRTQ
TEFDNSYTFK VYLFQFINYY SSIFYIAFIK GSISSVPGRR ILGLRPEECD PAGCMVELVP
ETKRQKSERL RHEKQLEMKC SKEEVPRWER DYVLNPIYEQ FLFDEYLEMV IQFGFVTLFV
SAFPLAPLFA LLNNIMEIRL DAYKFLITTR RPMPQRAKDI GIWLPILDGI SRAAVLVNAF
VIAFTSDFIP KLVYRWVYNH QELYGYVNNS LSIYDATSMA AWSDINPNIT TCRFRDYRNP
PCTVVQSNEC SNEYSLTMQW WIVLAFRLAF VLVFEHVVSA VKAFVAYIIP DMPTRIFIQL
QRQRFLARQA RLSDMSNTAS ARNAANGKYA QSKGHAASSD RDDVAFQPGL FDKNDERISH
ELEKVMRYDL HRRPTSFQSN SNAPSIESFR TCSDNTLDTD EERPSVPSSG AAQEEEFSGH
FPPVWNI
//