ID A0A0B2W4W2_TOXCA Unreviewed; 736 AA.
AC A0A0B2W4W2;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN Name=Hexdc {ECO:0000313|EMBL:KHN88285.1};
GN ORFNames=Tcan_13753 {ECO:0000313|EMBL:KHN88285.1};
OS Toxocara canis (Canine roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Toxocaridae; Toxocara.
OX NCBI_TaxID=6265 {ECO:0000313|EMBL:KHN88285.1, ECO:0000313|Proteomes:UP000031036};
RN [1] {ECO:0000313|EMBL:KHN88285.1, ECO:0000313|Proteomes:UP000031036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PN_DK_2014 {ECO:0000313|EMBL:KHN88285.1};
RA Zhu X.-Q., Korhonen P.K., Cai H., Young N.D., Nejsum P.,
RA von Samson-Himmelstjerna G., Boag P.R., Tan P., Li Q., Min J., Yang Y.,
RA Wang X., Fang X., Hall R.S., Hofmann A., Sternberg P.W., Jex A.R.,
RA Gasser R.B.;
RT "Genetic blueprint of the zoonotic pathogen Toxocara canis.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN88285.1}.
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DR EMBL; JPKZ01000255; KHN88285.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2W4W2; -.
DR STRING; 6265.A0A0B2W4W2; -.
DR OMA; MKYWEEL; -.
DR Proteomes; UP000031036; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06565; GH20_GcnA-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR038901; HEXDC-like.
DR PANTHER; PTHR21040:SF8; BCDNA.GH04120; 1.
DR PANTHER; PTHR21040; UNCHARACTERIZED; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000031036}.
FT DOMAIN 294..446
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
SQ SEQUENCE 736 AA; 85686 MW; C01CFF9E3D9232CD CRC64;
MECFRRKRLF RQILVAFLIC YVAWLAPNTV AHLRGNSNIF LPKGVDQYPM FIDGSFVPAN
RIFHLDLKGA PPRMKYWEEL IPFIRAIGAT GILLEYEDMF PYSGRLGRLK SANAYTEGEL
LRILTLARSN NLEIIPLVQT LGHLEWILKY KEFAKYRESE QYPQPNTVAH LRGNSNIFLP
KGVDQYPMFI DGSFVPANRI FHLDLKGAPP RMKYWEELIP FIRAIGATGI LLEYEDMFPY
SANRIFHLDL KGAPPRMKYW EELIPFIRAI GATGILLEYE DMFPYSGRLG RLKSANAYTE
GELLRILTLA RSNNLEIIPL VQTLGHLEWI LKYKEFAKYR ESEQYPQVIC LGDDEAVNLV
LEALAQVTRV HKDIGINFFH IGGDEVFQIG MCESDKKVME EMGWGHDQLL VHHFMRIAKY
VKANVEGVRI VMWHDMLVGV SQELIKQIGL NLLVEPVVWQ YAEDLDQSLN NDLWPSLAIN
FHYIWAASAF KGADGPSQYI LNLPHYLKNH VSWMKQMNDV YEQFLQFRGV FVTGWQRFDH
FAVLCELLPV SLVSAAFNFA VLKNGPSNDI GKLPVAILVR EAERVLKCKL APMDVFGSED
RDFEHCFFPG RGVYAAINHL HRNLRSVEEK VFKDYRVLGW LSDFNDRYEY TQVWYLSEVR
RKVLDYMHFL RRATGFVKEA MIPIFFEDTI QEFVIQYINP TMDRLQKLLE RIEKLSKLRD
FPRLTFQTTD DLRRQS
//
