ID A0A0B2WEP5_METAS Unreviewed; 3890 AA.
AC A0A0B2WEP5;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:KHN94311.1};
GN ORFNames=MAM_07840 {ECO:0000313|EMBL:KHN94311.1};
OS Metarhizium album (strain ARSEF 1941).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=1081103 {ECO:0000313|EMBL:KHN94311.1, ECO:0000313|Proteomes:UP000030816};
RN [1] {ECO:0000313|EMBL:KHN94311.1, ECO:0000313|Proteomes:UP000030816}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 1941 {ECO:0000313|EMBL:KHN94311.1,
RC ECO:0000313|Proteomes:UP000030816};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- PATHWAY: Mycotoxin biosynthesis. {ECO:0000256|ARBA:ARBA00004685}.
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN94311.1}.
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DR EMBL; AZHE01000037; KHN94311.1; -; Genomic_DNA.
DR STRING; 1081103.A0A0B2WEP5; -.
DR HOGENOM; CLU_000022_37_9_1; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000030816; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0046483; P:heterocycle metabolic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901360; P:organic cyclic compound metabolic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd20483; C_PKS-NRPS; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030816};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..434
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2232..2309
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3372..3446
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2312..2338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3890 AA; 427681 MW; F743890971C483C8 CRC64;
MAARVNGRAD DPSVIVGLAC RVPGANSPSK LWESIAEQRD VQQKMPEDRL KVDSFFHPEP
THKGTTNARF GYFLDQDIGD FDAGFFGISG KEAEAMDPQQ RLLLEVVYEA LENAGITLQE
IRGSLTSVFC GSFTNDYNAM LTKDLEYYPK YTVTGTGDAI LSNRISYFYD LHGTSVTIDT
ACSSSLVCFH LGSQTLQNGE ADISIVVGSS LHYDSNVFVT MTDLGMLSTN GRCAAFDASG
SGYVRGEGIA CAILKRKSDA IANGDNIRAV VRATGSNHDG KKNGITLPNS VAQEQLIRTT
YERAGLNPNH TQYFEAHGTG TAAGDPIEAR AIGAVFSPGR NEPLFVGSVK TNIGHLEGAS
GLAGLIKTTM ALENKYIPPN MHFKTPNPKI DFQNWKITVP TKLIEWQVPD GVPRRASINS
FGYGGTNAHV VLEEYARDEK LPVPVPSEPI ANGVHSRPYL VPLTSHSPKA GELSEENLKA
YLNSGEDVTI ADLAYSLSTR RTLHQQRSFV VANDKAGLVD QLSSPRPAAP WTLAKNAVPK
LGFIFTGQGA QWFAMGRQLI EECPHFRQTL QRCDTVLKSL PDAPEWSIVA ELNKSKETTL
LGETLYSQTI CTALQLAIID LIECWGIKPS AVVGHSSGEM GAAYAAGILS FESALIAAYY
RGRYMSASRT DCVPGGMMAV GLPENKCLEE LKPYAGRLTI AAVNSPSTMT VSGDEEAILD
LKEKLKEKKI FVRQLIVKQA FHSHHMSPLA PAYENALKNN YSFKTKAPRC RMFSSVTSRV
ADHEKMGASY WAANMVQAVR FSDALTGVLF NEEDEQNVDI LVEIGPHPAL KGPARQTVQS
LKLDVPYVAS LTRGVPDFEG LLTMAGTLFS LGYPVDIVAA NQNLSQNSQG ALVAAPTGTM
LNDLPKYTWE HRRYWSETRY IREHRQREFR HATLGHRVAG SVVRHPLFRN YFRLSELPWL
NEHVVENKVV FPGAGYISMA IEAAIRTEDI ESVKMIYLKD IVVKNALLIP PTDEGVEVLL
ELKPVTLSAK SHSDTWYEFN VFSYDESSNC TSHCHGLISV EKGHAAPVDY TGRYPEGTNF
NELRKKTYRS MAAGTFYKNM AELGLAYGEK FRLLKGSIES GVGFAMSNLV FDPKHLPLDA
GDETVLHPTL LDSFFHVIFH AVENRLGRPL DEPYVPSFFR ALTISGNFFD SRYSTDVKNF
RVGSFTKLPS PRVAINDMIM QNDKGELMME IAGLEVTSLG REDPEGQGPR TLFYRQRWQP
CFEMMTNIKG RSLSEIVDIF AHQYPNTRIL HITSDLNKTR ELIEKLGAKN GERRRFRQLD
IWHSQSYDFG EEADKLAKEC RGLVNVTEPA PGLYDLVIVS EAGVNAVPLM NNAGCILFDG
RKDFSAADFQ LLFSSPTCTA VRKAAEPFGL SSELSIIMPT GKPSARTSSI LKELESTHGG
KITLTDFSEL SSKGTAPLAK DVVVLAGLDE AISDKTAFKG AQALLTSLEK NVIWPTEGAT
LEANRPDNAM YIGLVRAARS ENDTLRAVTF DFGIDSPAKS VAVNIVRFLD TRITEDELTE
RNGTIYIPRV EADDERNCKL RNGPNQEPHL EPFGTAQTRT PLALRIGKVG LLETLYFDED
TQVIDTEIND NEIEVETKAS SINFRDVAAS MGIIEDFNLG DECAGICTKV GAKVKGFEVG
DRVVALRPGQ GAHRSLVRNP ASWCYKLPDT MSFTDAAAMP LILGTAWFAL DHTARLATGE
SVLIHAAAGG VGQMAIQIAQ RAGAHIYATM GSPAKRQLLK DVYGLKEEQM FSSRDASFAK
GVMDATGGKG VDVVLNSLAG PLLHASWACL APFGRFLEIG KRDIHENSKI AMDPFRRNVL
FASIDLVTMF EKNEALGEKL FKECFALLAN GEIRTPATIK EVPYSEVVKG FRLLQMGKHT
GKIVLVPHPE DMVPVMRGGY RHVRLFSSSK TYLLVGGLGG LGRALSQWMV RKGASKLAFL
SRSGADKTEA KATIDWLLER GVDATVYRGD VSKLADVQSC VDQIGSSLGG IFQAAMVLQD
KPLETMTYEQ WQRCCQPKVE GTKNLHEASL GYNLDFFICF SSVAAVVGSK AQANYSAANC
YLDAFMRHRR EIGLCGTTMN VGAVTGVGVV AENEELQRIM LRMGMDTINE EELLYQLEEA
VLADKPANAM TARGCNGNQI ISGVGLISPD VYWASKPIMK NLYANHDFGA EGAGQSSKNL
LALVSEEPDM EKKTGILLDG FLEKIAGVLA TPRESILPSN PLSAYGLDSI VAVEFRKWFR
KEVQVDIALF DILGAASINA LVSKTIRMVS TTSTSKATTS DRTEKKVAAE SESTGADSNV
SAMATGQLKK AQHAGVVPLS TFQSRLWFVH SFLEDKSFLN LPIVLRIRGK PHYPTLQKAI
QEMAVRNPAL RTAYFEGDEF AVQEPLEDFE LGVDLRDLSN EADVEKALEE FVKYNRKIEM
NVEEGEVATY SLAKLSEEEW AVVGMTHHIS IDRASLFPMM SQFVAIYDAL RTGNDLATVS
APEFNYVDFT LWHNARLASN LMKPDLDWWK KTLQGIPQSG KVLPFAKGER PARSDPRRQA
VRAKLNAKLF ARMKRIAAQS NGTPFHFVLA AFRAFLYRYT EDKDLVLLMV DGNRPHPDTD
PLMGFFVNLA PVRCNDDCEV AFDQLFQATK SRALDAMAHS GVPFDTIVDI MNVKKTSSHM
PVGQIAVNYQ IHGPVPTYTT CDFVVENIES DDIPTAADIQ LEAIETSEHS LDLKIEYSTA
LYYNPDMERF LDNFSTFLAS CIKDHRQPVD EISMCGPLEI EHLKKEYWNM ETKANQWAEQ
SVLDVITKMA RQHPQTAAIK TSDCRSITYK QLIENAESVA SELLDAGARP GDRIGLVALP
GVEAVTGMLA ALMTGSGYVA LDTDFAQDRL SFMLSDSGAR ILLAGPGQEH LVADLLSKMA
TGLKVIRIEE AASAGRSVAH PRARRPDDPF YMIYTSGSTG TPKGVVLKES NTQAMLATLS
KDYALSHRDN FLAHTTTSFD LSVVQIFGGL TAGATVSVAS WETRKDPVAL ADFMMKEGVS
VTYFTPTQFA LLMEFNSEAL RKCSKYRVAY FAGERLPVRV AKAFYDLGTP ATLYNTWSPS
ELVVQTSISK IDYPGEGVVS LPIGYPMDNC RHYLVDVKGN PVPAGHIGEL VVGGVQVGAG
YLNRPEANAR SFVEDPFASD DDRKRGWNKM FKTGDRGRFR PDGQLEFHGR IAGDKQIKLR
GFRIDLGEVE QVIFRKSQSL KKTGSLTDIA VVARTVDSDE LQLIAYLVPK AKVISDADKM
AIISQLHRKI KPHLNYYMLP NGYQFLPELP ATLGGKVDRR NLLERRLDLL FPSSITTQPS
DNVPATTKTS TGSTQDLEAT VLALFRTTLG GEIELNDSFF EKGGNSILLV RLQARVKKLF
KIAPPLPVLI REPTAAAVCA YLRRAKGGDA TIKGGLGNRV SWNVETNLPN TSQYMPRYGI
PRIDRDELKS ILLTGAETFI GVHLLAEILR TKRDATVHVL GSTEELASQG LTDLLLRLDL
VTDNLTLDDI SNRVKFVPGS LSQSHFGLSR SAFRELGQTV ESIYHLGGHV SLLKPYSSLK
PVNVSPVFDI IKLAGLGSRL SDINYLSTWS VAHLQTWSAS RRTREEYVTG EEDSSHFSPP
TEDECGYFKT RWVSEGLLTK AAQRGFPVTI TRTSGVTAAV RGSGVPNPGD EFITRIVVSM
IESGMVPQIG RADQPSFAVD VVPVDWLVSS FFALTSRKEA LSHVPSSEMH SAPQIYHITN
PLPLRLKDLP RIIAQLQSEQ TTPRLVSLDQ WLSSMESAED EDADSQVVRS TVLRQYLSTG
AVMFSLDNKK TMDVLDVLNP GAAAGCPAVD AELLGTLLRK LRRAENAFSG
//
