ID A0A0B2WLF2_METAS Unreviewed; 1078 AA.
AC A0A0B2WLF2;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=PX domain-containing protein {ECO:0000313|EMBL:KHN96896.1};
GN ORFNames=MAM_05005 {ECO:0000313|EMBL:KHN96896.1};
OS Metarhizium album (strain ARSEF 1941).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=1081103 {ECO:0000313|EMBL:KHN96896.1, ECO:0000313|Proteomes:UP000030816};
RN [1] {ECO:0000313|EMBL:KHN96896.1, ECO:0000313|Proteomes:UP000030816}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 1941 {ECO:0000313|EMBL:KHN96896.1,
RC ECO:0000313|Proteomes:UP000030816};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN96896.1}.
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DR EMBL; AZHE01000012; KHN96896.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2WLF2; -.
DR STRING; 1081103.A0A0B2WLF2; -.
DR HOGENOM; CLU_007315_0_0_1; -.
DR OrthoDB; 2727031at2759; -.
DR Proteomes; UP000030816; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06093; PX_domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775:SF47; MEIOTICALLY UP-REGULATED GENE 122 PROTEIN; 1.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR SMART; SM00313; PXA; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030816};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 97..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 177..359
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 563..679
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1078 AA; 117239 MW; 7D2C5F43A66CB492 CRC64;
MGSTTSDGVT QPAAPWESTP EHEAQKPETA TIDGRDDLVK TDEVDKSYTA RRSVARASTS
EPTDLEDKAS ALAAKALSFI SEATPATLGG VAIAASAIIY AILGRIGLLL IGAIAGVLVF
ISLENKYPDV IAQAVRGEKG PEVLDRVWLD LKQCRRDDCT QEGDEEETAF RSFDDFRPET
RDALGGLVDA IIRDYVKWWY SPIIPGDHSF PLSCRKTLNS YLLSVSNRIC KKRPADAFLD
LLTNSSSIVI ALLSELAAAF ADVPPETNMT AADAVYNYLA SHSDSRLANL LNQKQQATKF
RMVAEDLLGF LDQGSQNCDP ARIFLREVLA NSVLETTLQT CSKAEWINGW IVYLLEAGEP
DINHAIDVGM QTGRDNGTNV FADMDGNVGN VGIAKPVAAR PSLEMDRSRR KESLGHKKKL
SRADEELEGA MEGVQRMNAI MSRRDERQQR DDASLDMTDK PSHSVEWRSE NQRSPGKPEE
PVSRASGEKS SPRGTSTDST KSEAQNTPVT PRSGIESASQ QSSPQRSSEQ PFTSFDQIIP
PGQSEDNEED GPRKAPLSLH NASFTLHDDA TGDGSKIRSK PSWDYLIQVE PSSSTHTGWM
IVRRYSDFQT LHEILRRIAT ISGATAFTEL HKELPSWKMH TRESLRGELE RYLRDGCWYQ
SLAESEGMKR FLEKSQGHTH GNPKSFGWET VGKNMLDVLN IAPKGAVEGG KTLVGGVSGV
FGNIAGLTRK STSQSVDLTQ SVNRLSISTP PRADPARSPA RSDRGSLDSQ RSSVISTQPG
KMAPMSRRPS YQSVGEIDAE TGRTGRPAER NEVGPGLGSG RPSLEHSRAS SLAALRSPST
ASLDLAKLPP PPDEMTSDYE SSLNGEETQT RQGDGASTHQ TIRGLPTSSS APSLSTLGGG
GGRRTATKPA KQYSHMSEQE TRVAVELLFA VINEMYTLSS AWNIRRTLLT AAKSFLLRPG
NPSLLTVQSL IQSSVLDANT SDAGIAAQLR KLRENTLPTE QERAAWPEEM TADEKERLAI
KARRLLIQSG VPAALMGVMG QAATGEALGR VFDCLQIEEV ARGLIFGLML QAVRILTH
//
