ID A0A0B2WYY6_METAS Unreviewed; 772 AA.
AC A0A0B2WYY6;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=RhoGAP domain containing protein {ECO:0000313|EMBL:KHN98754.1};
GN ORFNames=MAM_03216 {ECO:0000313|EMBL:KHN98754.1};
OS Metarhizium album (strain ARSEF 1941).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=1081103 {ECO:0000313|EMBL:KHN98754.1, ECO:0000313|Proteomes:UP000030816};
RN [1] {ECO:0000313|EMBL:KHN98754.1, ECO:0000313|Proteomes:UP000030816}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 1941 {ECO:0000313|EMBL:KHN98754.1,
RC ECO:0000313|Proteomes:UP000030816};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHN98754.1}.
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DR EMBL; AZHE01000006; KHN98754.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2WYY6; -.
DR STRING; 1081103.A0A0B2WYY6; -.
DR HOGENOM; CLU_010730_3_0_1; -.
DR OrthoDB; 5482027at2759; -.
DR Proteomes; UP000030816; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07652; F-BAR_Rgd1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF138; RHO GTPASE ACTIVATOR; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000030816};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 98..374
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 583..769
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 223..250
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 83071 MW; 2A9555E2AF7AE3D1 CRC64;
MADLRGSNDD DDVDAVPHSH QHQHQQDRLI GSPTHDPQSS QPDADGAGGT RLENSSNGKQ
SAEARDVGAS QQGPAAPTAA ASGTEAQAKP AVDPAVAKHV NDVMTSELGI PTLLNRLKQS
VASAKEFALF LKKRSVLEDD HAQSLRKLCR LTQDNSRRPE HRQGTFSKSY DEMVFIHDRM
AENGSQFAAS LHQMHEDLVE LVANGERARK MWKANGLAAE HKVADLEQVM RKAKAKYDSL
AEEYDRARTG EARQGGKVLG AFKAHKSAAQ HEGDLLRKVQ AADQTYASHV QSLQTEKSHL
EKSARPEAVK ALRELISETD SAVTLQMQKF AAFNEKLLLG NGLIVSPFKT QGPEGAGQPR
SLRQAVASID NEKDFNDFVA GQHTRIQPYT EVKYERNPLL MPNPSSISQP FPQSMPTAQP
GGSAGPPPEG PSSLGVASRS SVGQFGAMGG VVSSQGPPAQ QGGITDSARP YAQSHGRSFS
QGNMLSQQVS SLQQQFSSRN SAQSAPRYGS AAGSQGPPQL GALSFQGSQP SPKSSTPPQG
APSQPPTDPR SSSSAYGGAP PPAYAPASES SSPTASKKLV FGTSLSRLYE RDGLAVPMVV
YQCIQAVDLF GLGLEGIYRQ SGSHQLTSGP ESSNPALDFT NPENFYHDVN SVTGLLKQFF
RDLPDPLLTG EHHDAFVKAA KHEDDILRRD SLHAIINALP DPNYATLRAM TLHLYRVMDN
AHVNRMNSHN LAVIFGPTLM GSDPSTAIAD AGWQIKVIDT ILQNTYQIFE ED
//
