ID A0A0B2X2W8_METAS Unreviewed; 484 AA.
AC A0A0B2X2W8;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=poly(A)-specific ribonuclease {ECO:0000256|ARBA:ARBA00012161};
DE EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
GN ORFNames=MAM_01442 {ECO:0000313|EMBL:KHO00664.1};
OS Metarhizium album (strain ARSEF 1941).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=1081103 {ECO:0000313|EMBL:KHO00664.1, ECO:0000313|Proteomes:UP000030816};
RN [1] {ECO:0000313|EMBL:KHO00664.1, ECO:0000313|Proteomes:UP000030816}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 1941 {ECO:0000313|EMBL:KHO00664.1,
RC ECO:0000313|Proteomes:UP000030816};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001663};
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KHO00664.1}.
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DR EMBL; AZHE01000002; KHO00664.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B2X2W8; -.
DR STRING; 1081103.A0A0B2X2W8; -.
DR HOGENOM; CLU_027974_3_0_1; -.
DR OrthoDB; 341493at2759; -.
DR Proteomes; UP000030816; Unassembled WGS sequence.
DR GO; GO:0030014; C:CCR4-NOT complex; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:UniProt.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR039637; CNOT7/CNOT8/Pop2.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10797; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT; 1.
DR PANTHER; PTHR10797:SF0; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 7; 1.
DR Pfam; PF04857; CAF1; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030816};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 52226 MW; 5AC2F72219E79A04 CRC64;
MPPPIRGFGA GPGVGGPFHQ PGFPSHGQPQ GGPMGGNQYL NANTQISSFA GANGNAFAGL
NGSGFADSGF GSQSARMGFA HGPAAGLQQP QHGGQVQHSV LMEHPTMRAQ TNKGRIREVW
KHNLEEEMGV LRDIVDKYPY IAMDTEFPGV VARPMGSFRG KSDYHYQCLR TNVDMLKVIQ
IGLTLFNEEG ETPPARPGPD LGLGPKAMKA ASQGPFPYSW QFNFKFSLQD DMYNEKSIES
LQQAGIDFNL LERDGIDPKA FAALLIPSGL VCFDDARWIS FHGGYDFGYL TKLLICTPLP
NDEAQFDSKM KLYFPTTYDV KHLMKYAIRL HTQGFLTPND PAVVEILNKF EHKSGLENIA
ETFKVKRIGS AHQAGSDSLL TGKVFFQMRD RIFNGAIPED HIGRVWGLGV PEGPMGPMMQ
HAGNDLGQNG GTPSTPNQVP ASLISSPAAA QNHNSNGVMS HMGPMTPGGG GGVFGNFAFA
GNSR
//
