ID   A0A0B2X6B8_METAS        Unreviewed;       607 AA.
AC   A0A0B2X6B8;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Protein phosphatase 2C domain containing protein {ECO:0000313|EMBL:KHO01934.1};
GN   ORFNames=MAM_00935 {ECO:0000313|EMBL:KHO01934.1};
OS   Metarhizium album (strain ARSEF 1941).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=1081103 {ECO:0000313|EMBL:KHO01934.1, ECO:0000313|Proteomes:UP000030816};
RN   [1] {ECO:0000313|EMBL:KHO01934.1, ECO:0000313|Proteomes:UP000030816}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 1941 {ECO:0000313|EMBL:KHO01934.1,
RC   ECO:0000313|Proteomes:UP000030816};
RX   PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA   Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA   St Leger R.J., Wang C.;
RT   "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT   adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC   -!- SIMILARITY: Belongs to the PP2C family.
CC       {ECO:0000256|RuleBase:RU003465}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHO01934.1}.
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DR   EMBL; AZHE01000001; KHO01934.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2X6B8; -.
DR   STRING; 1081103.A0A0B2X6B8; -.
DR   HOGENOM; CLU_021251_2_0_1; -.
DR   OrthoDB; 202023at2759; -.
DR   Proteomes; UP000030816; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro.
DR   CDD; cd00143; PP2Cc; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 2.
DR   InterPro; IPR015655; PP2C.
DR   InterPro; IPR000222; PP2C_BS.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   PANTHER; PTHR13832:SF828; [PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13832; PROTEIN PHOSPHATASE 2C; 1.
DR   Pfam; PF00481; PP2C; 1.
DR   SMART; SM00332; PP2Cc; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   PROSITE; PS01032; PPM_1; 1.
DR   PROSITE; PS51746; PPM_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003465};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912,
KW   ECO:0000256|RuleBase:RU003465};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030816}.
FT   DOMAIN          156..572
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51746"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          577..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        589..607
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   607 AA;  65733 MW;  9E84AEAF6C2BEF74 CRC64;
     MPAASPSVLD ARSSASRARR RSRFQPTCAR RRSTCPLVTS RNCVPLPRFP DQLLRHCFHT
     YFVTHLPSSS LHPDSHRTIG PGHKLPRDAS TPHTPSSGPS PAAVSIPNMQ SRDLTVVRIP
     LRRAKHHFGS ATARGSRPYN EDADQAGTVD IPAFAKRGPL SVRQKPGEPT PADSVLGDPQ
     IFYFGVFDGH GGTQCSHFLR DELHGYIEEA ALEFGLQSSL RKSKPGRDQP KPTAGERPIS
     NQQALDSVDM KSAEDVQPQM DVPDPENRAF VVDSPNHEPA LPDAKSPPAE SQNMDKAISL
     ERDLVKAYRN AVGGYFRRFN PEHFDISSEA GKQASITVES SLAYAFLRAD LDFVSAQARK
     ADPDASDQPL NDDEILGAPH TTPSGHGIGG TTRFKGGSTA SVALISTPTT APFWHPAAHS
     TLVAAHVGDS RILLCETATG LPHPLTSDHH PTTPTESRRL RRYAPAGSMV TGDSFGEERI
     AGLANSRAFG DIRSKRIGVS AEPEITRVEM GPAEFSFLVL MSDGVSGTLS DQEIVDIVKE
     ARTPDDGARN IVEYATEVSK DGDNATCQVV RLGGWERRSE GGLGSMGTKE IRDIRKAEAQ
     DPRRGKR
//