ID   A0A0B2X6H5_METAS        Unreviewed;       618 AA.
AC   A0A0B2X6H5;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Probable Xaa-Pro aminopeptidase P {ECO:0000256|ARBA:ARBA00020658};
DE   AltName: Full=Prolidase {ECO:0000256|ARBA:ARBA00032413};
GN   ORFNames=MAM_01669 {ECO:0000313|EMBL:KHO00891.1};
OS   Metarhizium album (strain ARSEF 1941).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=1081103 {ECO:0000313|EMBL:KHO00891.1, ECO:0000313|Proteomes:UP000030816};
RN   [1] {ECO:0000313|EMBL:KHO00891.1, ECO:0000313|Proteomes:UP000030816}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 1941 {ECO:0000313|EMBL:KHO00891.1,
RC   ECO:0000313|Proteomes:UP000030816};
RX   PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA   Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA   St Leger R.J., Wang C.;
RT   "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT   adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KHO00891.1}.
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DR   EMBL; AZHE01000002; KHO00891.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0B2X6H5; -.
DR   STRING; 1081103.A0A0B2X6H5; -.
DR   HOGENOM; CLU_011781_2_3_1; -.
DR   OrthoDB; 869at2759; -.
DR   Proteomes; UP000030816; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR   PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000313|EMBL:KHO00891.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000590}; Protease {ECO:0000313|EMBL:KHO00891.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030816}.
FT   DOMAIN          7..143
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          326..544
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          555..617
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   618 AA;  68239 MW;  00C5A6AE6A94FC02 CRC64;
     MANSSPRLTR LRDLMRERKI HVYVIPSEDS HSSEYIAACD ARREFISGFT GSAGCAIVTL
     GAAALATDGR YFNQAAKQLD SNWTLLKQGL QDVPTWQEWA ASQSAGGKTV AVDPSLLPGS
     AAKKLNDQVR KAGGAELVPL DENIVDIAWA DSRPDRPCRP VRVLPDEIAG KSVTTKIEEL
     RQELAKKNCP GFFVSMLDEV AWLFNLRGND IPYNPVFFSY ATITPEAAIL YVDESKLDES
     CKAHLRANRV QVKPYDCFFP DARQLHTEVK LKRQAGGDDT VAGNFLISNK GSWAMSRALG
     GDGSVEEIRS PVGDAKAIKN GIEMSGMRAC HVRDGAALIE FFAWLEDQLL HKKVIIDEVQ
     AADKLEELRS KHQRFVGLSF PTISATGANA AIIHYGPEKG CCAIIDPGSV YLCDSGAQYR
     DGTTDTTRTL HFGKPSDDEK TAYTLVLKGL IGLDTAVFPK GTTGFALDCL ARQHLWKNGF
     DYRHGTGHGV GSYLNVHEGP IGIGTRVQYT EVPLAPGNVL SNEPGYYEDG NFGIRIENIM
     MVREVQTEHC FGDKPYLGFE HVTMVPYCQR LIQKDMLTAD EKGWLNAYND EILKSTRGFF
     KGDDLTMTWL TRETRPIE
//