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Database: UniProt
Entry: A0A0B3VVL2_9FIRM
LinkDB: A0A0B3VVL2_9FIRM
Original site: A0A0B3VVL2_9FIRM 
ID   A0A0B3VVL2_9FIRM        Unreviewed;       439 AA.
AC   A0A0B3VVL2;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   20-JUN-2018, entry version 28.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=QX51_10940 {ECO:0000313|EMBL:KHS56878.1};
OS   Terrisporobacter othiniensis.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales;
OC   Peptostreptococcaceae; Terrisporobacter.
OX   NCBI_TaxID=1577792 {ECO:0000313|EMBL:KHS56878.1, ECO:0000313|Proteomes:UP000031189};
RN   [1] {ECO:0000313|EMBL:KHS56878.1, ECO:0000313|Proteomes:UP000031189}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=08-306576 {ECO:0000313|EMBL:KHS56878.1,
RC   ECO:0000313|Proteomes:UP000031189};
RA   Lund L.C., Sydenham T.V., Hogh S.V., Skov M.N., Kemp M.,
RA   Justesen U.S.;
RT   "Draft genome sequence of Terrisporobacter sp. 08-306576, isolated
RT   from the blood culture of a bacteremia patient.";
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00747961}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KHS56878.1}.
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DR   EMBL; JWHR01000099; KHS56878.1; -; Genomic_DNA.
DR   RefSeq; WP_039679954.1; NZ_JWHR01000099.1.
DR   EnsemblBacteria; KHS56878; KHS56878; QX51_10940.
DR   Proteomes; UP000031189; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031189};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00747973};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031189}.
FT   DOMAIN      135    263       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      347    416       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     143    150       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   439 AA;  50339 MW;  39B480331FFBA7C8 CRC64;
     MDIVSLWEKT LQLIKGEVST ASFNAFFKEI KPLKQISNEL IFLAPNEFIQ NILENRYLNL
     IESCVSQLSL KKYQIKFILD EKEIQDTNEE DKSTTIKKSY PNLNPKYTFD TFVIGNSNRF
     AHAACVAVAE SPAKAYNPLF LYGGVGLGKT HLMHAIGHHI MCQQEDPKVV YVSSEKFTNE
     LINSIKNDKN EEFRNKYRNV DVLLIDDIQF IAGKEGTQEE FFHTFNALHE ANKQIIISSD
     RPPKEIPTLE DRLRSRFEMG LITDIQPPDF ETRIAILRKK AQLENINVPN EVMTYIAKYI
     KSNIRELEGA LTRVVAYSSL TNKNISLELA TEALKDIISN PKSEEITVNR IKEKVSEAFN
     IKMDDFNSKK RTRTIAYPRQ IAMYICRELT DLSLPKIGSE FGGRDHTTVI HAHDKVTKDI
     EENQQIKDKI DKIISDLKG
//
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