ID A0A0B4H4H2_METMF Unreviewed; 343 AA.
AC A0A0B4H4H2;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Farnesyl pyrophosphate synthetase 1 {ECO:0000313|EMBL:KID94600.1};
DE Flags: Fragment;
GN ORFNames=MAJ_09450 {ECO:0000313|EMBL:KID94600.1};
OS Metarhizium majus (strain ARSEF 297).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium;
OC Metarhizium majus.
OX NCBI_TaxID=1276143 {ECO:0000313|EMBL:KID94600.1, ECO:0000313|Proteomes:UP000031176};
RN [1] {ECO:0000313|EMBL:KID94600.1, ECO:0000313|Proteomes:UP000031176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 297 {ECO:0000313|EMBL:KID94600.1,
RC ECO:0000313|Proteomes:UP000031176};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|RuleBase:RU004466}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KID94600.1}.
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DR EMBL; AZNE01000109; KID94600.1; -; Genomic_DNA.
DR RefSeq; XP_014573594.1; XM_014718108.1.
DR AlphaFoldDB; A0A0B4H4H2; -.
DR HOGENOM; CLU_028376_2_0_1; -.
DR OrthoDB; 509027at2759; -.
DR Proteomes; UP000031176; Unassembled WGS sequence.
DR GO; GO:0004161; F:dimethylallyltranstransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004311; F:farnesyltranstransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004337; F:geranyltranstransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046165; P:alcohol biosynthetic process; IEA:UniProt.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR GO; GO:0043386; P:mycotoxin biosynthetic process; IEA:UniProt.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR InterPro; IPR039702; FPS1-like.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR11525:SF0; FARNESYL PYROPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR11525; FARNESYL-PYROPHOSPHATE SYNTHETASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000031176};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004466}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KID94600.1"
SQ SEQUENCE 343 AA; 38785 MW; 17ECAB3BF96AD27E CRC64;
MDALRHELRA AYASLDATVT QYLVSEGFGD ATVNHFSQCF SANVGTGKLH RGLATLYIGK
QLAKNEVSEE QSKQLSVLAW LVEMLGAHYL ILDDIMDDST TRRGEPCWYR QPQIGLMAIN
DACILKSTIF FLLKTFFRQH PAYTNMVDLF VDNGLHTELG QLCDLAAARE PDIANFTMEQ
YWAIVKDKSS YSISGPVTLA LEYWRLATPK NLQQTRDFSV ALGEYFQVND DYVDVFGDYA
VTGKHGTDIQ DNKCTWFIIE ALSRANDAQR QRLLEGYGKK DASRVDEVKQ VFAELGLQQA
FRAYEEQQRA KIEGIIAAVD ESEGLKRDVF HALFDGFRKG RQI
//
