ID A0A0B4HNP2_METMF Unreviewed; 1085 AA.
AC A0A0B4HNP2;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Cation transport ATPase {ECO:0000313|EMBL:KID94027.1};
DE Flags: Fragment;
GN ORFNames=MAJ_10021 {ECO:0000313|EMBL:KID94027.1};
OS Metarhizium majus (strain ARSEF 297).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium;
OC Metarhizium majus.
OX NCBI_TaxID=1276143 {ECO:0000313|EMBL:KID94027.1, ECO:0000313|Proteomes:UP000031176};
RN [1] {ECO:0000313|EMBL:KID94027.1, ECO:0000313|Proteomes:UP000031176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 297 {ECO:0000313|EMBL:KID94027.1,
RC ECO:0000313|Proteomes:UP000031176};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|RuleBase:RU362081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KID94027.1}.
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DR EMBL; AZNE01000139; KID94027.1; -; Genomic_DNA.
DR RefSeq; XP_014573021.1; XM_014717535.1.
DR AlphaFoldDB; A0A0B4HNP2; -.
DR HOGENOM; CLU_001771_0_0_1; -.
DR OrthoDB; 5480493at2759; -.
DR Proteomes; UP000031176; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01511; ATPase-IB1_Cu; 1.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR46594; P-TYPE CATION-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR46594:SF4; P-TYPE CATION-TRANSPORTING ATPASE; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000031176};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 433..451
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 463..481
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 493..517
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 529..552
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 679..701
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 721..747
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1024..1045
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1051..1072
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 281..348
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 21..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..223
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KID94027.1"
SQ SEQUENCE 1085 AA; 116149 MW; B5638A45DBC0F3A1 CRC64;
MGTECCSGHG SHDAVPAAVS EHNQDSLHHE EHGHHHGGHN HEQVQDHGHI HDHDHGPDPC
KGEEHCTQEG ECCDDEFCCD NPSLSETLAC CSSNEEHCDE KCILAAAALE CEKTCETDNL
DQKTAAGHEH QHDANGRHPS GACSSHLEKA FKQYSAYLDS ARCICRSVLE RGWSTTCCAN
QPKKTIPSAV PNALDDKAEI YASGRKVHRH DGPHHHHEIR RRGKMAKHQG EDDSCCEPAN
HDCCSDHDHA PGHDAIQPLD SSKSDGHRSI ERDVEKVEGL EHVALVVDGM TCSGCGNKMT
NTLNKIAGVS SVKVNFVMSH AEFEVDTSVN TAAEVIRAAE RATNFRCNRM ASDDQVLDVL
ASGKSAKTLL DCNIKGVAGT TILSKTTVRL SYVPTTIGAR DLFEKLQGQV EGLAPPGDDP
SVSSGRKRLY DQLFKTILAA VFTIPVLVLA WGSTPVNEKT RGIISLVLAT LVQIIAIPDF
YRPAIGALIH SCTIEMDMLV VISITAAYVY SVVAFGFRMA GKPLETSEFF ETSTLLITLV
ILGRLVAAFA RIRAVEAVSL RSLQTTTAVI VENNKDRTID ARLLQYGDKL KIGPDSGVPT
DGLVLSGQSD VDESMLTGES VPVSKGPGDA VIAGTVNKNG TLIAQLTRLP GKNTVTDIAQ
LVEEAQNSKP KLQDYADRVA SWFVPVVTAV AIIVVIVWLV VGFKVRKYKA GQSISNAITY
AVATLAVSCP CALGLAVPMV LVIAGGIAAR SGVIIKSAEC TERGRKVTDV VFDKTGTITE
EKLDVKKQVL LINEALAISI AKALVAGNKH PVSLAVANYL KDRSIPAETL NDVQVIPGAG
VEAKLNGSIL RAGNPKWTKT ASHDQVSRLQ NEGMTLLVVT QDGAPIAVFG LRTHLRKEAA
GVVSQLARRN ITTHLVSGDQ KHAVEMVGSE VGIPNIVSQC TPVEKRDYVA KLMQEGKCVM
FVGDGTNDAV AVSQADVGVQ LGSVLSSSDV TGKAADVVLL NGLEGIPFLL EISRVSFRRM
VFNFAWSAVY NVLAILLASG AFVNIRIPPA YAGLGEVVSV VPVIVAAMTM LLKKPKVSAP
TVERR
//
