ID A0A0B4HR42_METMF Unreviewed; 2552 AA.
AC A0A0B4HR42;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=ATPase-like, ATP-binding domain protein {ECO:0000313|EMBL:KID97733.1};
DE Flags: Fragment;
GN ORFNames=MAJ_06219 {ECO:0000313|EMBL:KID97733.1};
OS Metarhizium majus (strain ARSEF 297).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium;
OC Metarhizium majus.
OX NCBI_TaxID=1276143 {ECO:0000313|EMBL:KID97733.1, ECO:0000313|Proteomes:UP000031176};
RN [1] {ECO:0000313|EMBL:KID97733.1, ECO:0000313|Proteomes:UP000031176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 297 {ECO:0000313|EMBL:KID97733.1,
RC ECO:0000313|Proteomes:UP000031176};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KID97733.1}.
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DR EMBL; AZNE01000030; KID97733.1; -; Genomic_DNA.
DR RefSeq; XP_014576727.1; XM_014721241.1.
DR HOGENOM; CLU_001037_0_0_1; -.
DR OrthoDB; 1222064at2759; -.
DR Proteomes; UP000031176; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43047:SF46; HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:KID97733.1};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000031176};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 72..405
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1974..2199
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 2248..2372
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 57..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2470..2552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..121
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2470..2490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2509..2540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2303
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KID97733.1"
SQ SEQUENCE 2552 AA; 280458 MW; 402DF39D52354D27 CRC64;
MDGAVLVPDD VLDSRPPPPP RLFERLRQIA GYTWDETKEP IHSSYDFWLV FGTRFVSSKP
SPPSSGHNES SLGSITKLQS GRPSLSEHGN HVPPSETQST ETPKTPLPHR PSTPISSPPS
SADGPPIVEE SVVARVSSHN LREERAFQIA KNVAGTADPL GEHIAKPIDL LRLNPGPGDR
NHITVAIYQY PGANYLGKVL DFGPAFYQAR KEGDAYVSYR PATSSHLRPP INLEYFLDFA
IGAVQCLEIL HHGQGIIHGE IRGDAFHFNA EENKVRIVAF GTGLRSFEHG LTSTGWLTLS
KEVGVKNKLL YISPEQTGRM PAEPDTRTDI YSLGILMWTL LTQQPVYTGD TPMDIVQGVL
GRRVPNVATV RMDIPDVIGR IIQKCTAKNV ADRYHSASGL RHDLVNVQQL LSDGDSTALK
DLEIGTKDIS SFFILPTNMI GRTAEQSELV KVIDRVSRNH SLGSNRNRFP DGSGLANELV
VRDDVSSEGG ASSVRSVEGT NRRSGSFNLG GGSSEYKFPR NSFHPSILSD TQTLSNETVS
SNQSGPQLRP TRPWERHHSI SVETASAVES TGGPESGRIG GMTESSGSSL SRQLGAAKFR
RRGQCEVVAI EGAGGLGKSF LVQSVLGEAR RRGYCATAKF DTARRTAFGP LLKLLSSLFK
QVWGETNTET PFHQVLKQYV RPVWPMLHRV LGLPEFLLGP PESASPMVGR PSTNNSQQAG
QRSGVKSSSG KRRGSSPGSS PSPLSQHQVA NAAAAATAGS QSSQDYLCAG TSTKTTRLMN
TCLDILRVFT THKFICLCLD DLHFADDESL ELITQIIGAK MKMLIIMTYR PEELPRERMD
RIIYPAQLEE NHRNGRPRVT RISLEPLSET EILDYVSATL SRPKEEILSL ALVIQAKTAG
NPFYMREMLS ACHRKKCIWY DYRDSIWHFD LDRLFAQFQG EKDYDVLDTG FITRRLDELP
SAARAVLSWA ALLGNSFSFE IISRLMKGEF DYGDDDIPNC CPNLSKRSYT EAESIAGLQA
AIQAYIIVPS ETDDRFRFAH DRYVNASAAL KECNARRMHF IISQTLLKYY AVEARQREST
ACHICEAASI IKMRVPVRQE FRKLLIDCAQ AATENGARPT AAKYYGAAIQ LLQGDPWSDD
ADDVSYEETM QLYLRAAECH LFMGQLSLAN DLLSTLFANA KSAMDKAPAY VLQSRIFAQN
GNALAAFISL KECLAALGVP LEDEPTYEKC DKKFHKLAKQ VQGMDRQALM NPKKNTAPVT
ASIGAVLSET ASAAWWSDCL QYYHLTLVML DMHLTRGAFP QSGMAFLQMG VVGLARFNMT
QFAVDMGTIC QDLLYSARDA FSMARGQMLH SCFIGHVQYS MSLSTSQMDD AIELASVGGD
RLSTILSYGL CAVTKLFASE NLSDLEAFCQ YGCEDIVNWS LDTRGGALLV AVRQLSRALQ
GKTCTHEPLR VMTDDQHDSV GYKSWLTSQT QESNRSSLFY ESLELCALFL YGHYERAIDI
GQKCVEKLPM LWSARNSRLI LLFYGLARAG QLLRLMQDPR SQTDDFTAQT EEIVNELTGF
VKMMEDWSVV SDVNYRSWSR LLNAQVAELS QDHGQAIQHY EEALDHAAEH DFIFEEALGN
YVMAGFFIRR RARRSARAAL QDAVGLYRQI AAAGVASAIE EEHSLLLHGP TRNHRTVEVG
IQTDFVADPP PAQYRPVDGV DGDELTQVPS NAMSEFRGER IGAWRGSMRM PTEDGVGLPA
LDMIDLHAIL VSSQVISSVL QVNELLKTMC DVILQTCGGS ATRAAIIIQD NDTESWCVAA
SGDPERGASA HEPGLPLSGS TLIAENVVLY CTRFRESVFI PDLFADERFG NVNGGWLQRY
PGGKAIISIP ILHGTKPLLG VLYLEGEPGS FTDRNVTVLQ LLVNQIGISY SNALSMKNVE
KISAENRGMV SVQKRALAKA LEAETKAKHA EAEAKRNVKL AEEAAKAKAI FLANVSHELR
TPLNGVIGNS ELLRDSDLNR EQLEMADSIR VSADLLLTVI NDILDFSKME ADKMKLYIIA
FNPEEMVREV VRAVSYSNRE KTSKKNVKII QDINLPPMLI YGDPIRLHQV LGNLIGNSLK
FTEDGSVTIG ARLDAETKDS ATLTFWVRDT GIGIPAQQLA KLFQPFSQAD ASTARKYGGS
GLGLSICKSL IEIMMKGKIQ LESEESEGTT AWFTVTFEKA KADVSAGDAL GKASPPIDRY
SLMTSPFDRV ASPNPFMDLS QVSKEDVRIC VAEDNPINQK IAIQYAHRLG YPNVVAYENG
LKAIEGLRKK AAEGEPYHIV LMDVQMPVLD GYEATKLIRK DSIEAVRKVL VIAMTASAIQ
GDREKCLAAG MNDYLAKPVR SEVLKKKLDA YVDVSKAGVI DTVQSPISPI SPTTPNDLEA
NGTSLASIAS SNKVFRDTRA PNSSIIDPMQ EDAVYNMPLD STSLQAADSP VLSVNNNDQR
TLSMHLPQLT RNSTNHSDSQ PSTEASTPEA VSTGDPVALQ PKRQPKKLTK TRANSDAHGD
AEAKPVDKDG EKHKGVLTKK QPLADDPNGD AS
//
