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Database: UniProt
Entry: A0A0B4HR69_9HYPO
LinkDB: A0A0B4HR69_9HYPO
Original site: A0A0B4HR69_9HYPO 
ID   A0A0B4HR69_9HYPO        Unreviewed;      2586 AA.
AC   A0A0B4HR69;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   12-SEP-2018, entry version 27.
DE   SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:KID81974.1};
GN   ORFNames=MGU_10701 {ECO:0000313|EMBL:KID81974.1};
OS   Metarhizium guizhouense ARSEF 977.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Metarhizium.
OX   NCBI_TaxID=1276136 {ECO:0000313|EMBL:KID81974.1, ECO:0000313|Proteomes:UP000031192};
RN   [1] {ECO:0000313|EMBL:KID81974.1, ECO:0000313|Proteomes:UP000031192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 977 {ECO:0000313|EMBL:KID81974.1,
RC   ECO:0000313|Proteomes:UP000031192};
RX   PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA   Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA   St Leger R.J., Wang C.;
RT   "Trajectory and genomic determinants of fungal-pathogen speciation and
RT   host adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KID81974.1}.
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DR   EMBL; AZNH01000109; KID81974.1; -; Genomic_DNA.
DR   EnsemblFungi; KID81974; KID81974; MGU_10701.
DR   Proteomes; UP000031192; Unassembled WGS sequence.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   Gene3D; 3.40.366.10; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR013120; Male_sterile_NAD-bd.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52151; SSF52151; 2.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   SUPFAM; SSF53901; SSF53901; 1.
DR   SUPFAM; SSF55048; SSF55048; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000031192};
KW   Multifunctional enzyme {ECO:0000256|SAAS:SAAS00642580};
KW   Phosphopantetheine {ECO:0000256|PROSITE-ProRule:PRU00258};
KW   Transferase {ECO:0000256|SAAS:SAAS00555074}.
FT   DOMAIN     1639   1713       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   MOD_RES    1673   1673       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
SQ   SEQUENCE   2586 AA;  282687 MW;  2E5478A75CA2353F CRC64;
     MTTTEFHSSE DGSAQCEDTT LLLFGPQALS ANAETLNAFR DDVSSGPEST WIAAALESLP
     GCWEAFVTAF PKYCVTQNAS SLLSDLYRWF QAGSGSLPST EFPNTILSPL VVISHLSEYM
     RLLDMKEAQQ GEKRLDVLPP QTERQFEKFG ATAIRLAMII GGIVDAQEIL ETSGPTKALA
     TSWDTDAKEQ EMSNILQLFP DSYISVVYDE KRSTVTVPRQ SSEQLQQALG KEGIVAVEIG
     LRGRFHSQCY SNQISSFITY CSANADLALP SAEQLVYPLW CNTGDGASIS AGPLHDHGLR
     TMLVYKSDWH QLFEAARTAA MAGKLNALVI SFGPERCVPP SMMRKLGPQG TVIHMADART
     RRRRKQPDMT PRPPKEDDVA VIGMSIKVAG ADDVDEFWDL LCRGESQHKQ VPADRLKFDH
     VWRETNANRK WYGNFINDPD AFDHRFFNKS AREMISTDPQ QRHMMQVAYQ ALEQSGYFGS
     LASNDNKIGC FVGVCSADYE HNAACHPANA FTAIGNLKSF IAGKISHYFG WVGPSMCIDT
     ACSSSLVAVH QACKAVLSGE CSSALAGGAN IMTNSLWFEN LAGASFLSPT GQCRPFDVSA
     DGYCRAEGFA AVVVKKMSKA LADGDQILGT ILSSAVYQNH NCTPVFVPNA ASLADLFRDV
     VDQARLSPGQ IGAVEAHGTG TQVGDPAEYD GIKQVLGGPG RPKPLALGSV KGVVGHTECA
     SGAVSLVKTL LMVQRGIVPP QGSFKTMNTA ISAMSQDQID IVTDLRPWKV SDKEFRATLI
     NNYGASGSNA SMVVSEAPFA QDTAAVVVRN AKDVKVSPNN VDHLFRIFGH DERAIKAYCE
     RLMRFLSTHA KGQEHKMTIS TANVAFNLSR QGNPTLDKSY SFKARSLDQL MANLEAAVAG
     KTSVDIISAS KIPQRPVVLC FGGQVSTFVG LDRGLYDSCT VLRIHLDACD AICVTLPGVG
     SIFPGIFDRT PISDPVRLQT MLFAMQYACA RSWMDSGVRP VALVGHSFGE LVAMCISGSL
     ALHDALVMVS GRAAVIREHW GQERGSMMAV EGHDEQIVQD ILVASKSGAT IACFNGPTSF
     TLAGTGAEAL KLPTFASVRS KRLNVTNAFH STLVDALKDH LVQVGGRLKF RKPTIPIELA
     TRDKTDVSVL SEEYVADHMR NPVYFHHALQ RIAHEHPNCI YLEAGFNSTV AIMAGRALGW
     PKSSYFQSLS ITGDGAGQQV LVSATLSLWK EGLKVDHWAH NRAQTYAYAP LMLPPYQFEK
     SRHWLEMKAP PKTTIVDKSV DDAQPVSDRL FSFTGYADPN QRVAQFRINT ETDKYKTFVS
     RHKVASTAPI CPATLMVDMV IEALFNARPE LSPSQSDLQP QILSVQNVMA ICIDESRTAV
     LQLEAEDTCT ASRKWGWKIT STGPSGVGPE RLHVTGQLYL ASTADDKERS EFKRYERLAG
     GHRHCVQLLG DADADYIIHG GRNIYRAFAD VVDYAEPYQG VERLVGKGDE SAGRVVKQYS
     GDTWLDTHLS DCFSQVAGSD MYIATALDKW MRSPELGTGY PRPGPGAWHV LARHERAEDG
     SSFLSDLFVF DPATGSLTEA MLGIHYHRVS KLSMGKILAR FTPGLGGAES SAAASRSIPG
     KEAQTKESAN QKTTPEPAID VSAIIRQILS SISGLELAEI ADDSGLAEIG IDSLMGMELG
     REMEGAFKTP LMGDELAQVT TFRELVAHVA GVLGVVVADQ DGGSDAVDDS FEYVSSNSTE
     PTVTLPSDSD SEMPTKLGRA TQQGVQKSAH GSLQLLPSLV FEAFEETKSL TDDFIAKYRC
     ADYMDTVVSK QTHLCVALTV EAFELLGCPL RSAKAGHVLE RITHEREHTR LAEWLYKLLE
     KEARLIDVSS SGVITRTAVQ APKRTSDGIL AELRNVYPDH EWANRLTYFA GSHLAQVLRG
     EQDGIKLIFG TDEGRELVTG LYGDSLLNKL ANVQMQDMMQ RLIGKITTWD GPLKIMELGA
     GTGGTTKGMV PLLASLGIPV EYTFTDLSAS FVAAARKSFG KEYPFMKFRV HDIEKAPASE
     LVGTQHVVIA SNAIHATHSL SQSLASIRKA LRPDGFLMML EMTEPLWWVD MIFGLFQGWW
     LFDDGRRHAI AHQDRWKSEL RAAGYFRVDW TDGWRPETRI QRVIVAQDSE NPGFSLDATP
     MTFTRPSIVE ESAVKHKLKA QLDGYVRQYT RDFTFTSTGP RDGARAGITV AVTGATGSLG
     AHLVSHFASL PDVKNVFCLN RYSASADAED RQAEALASRG IRLSQEAKSK LRVLAVDSAK
     PLLGLQENGY LDLCKTTTHI VHNAWAMTGK RPVGQLEPQF AGMRNIIYFA RDAAASQHSK
     ISFLFVSSIA VMGHHSLIQG NDRFAPEERA VLDQILPNGY AQAKWVCERM LDETLHRHPD
     TFRTTSVRPG QIAGSTTSGY WNADEHLSFL IKSSQTLNSL PHLSGEMSWT PVNLVAGTVA
     DLVLANKTPH PVYHIDNPVR QPWSEVLPVL AAELGVLEGS IVPFTEWVQR VRTFPGSLED
     NPAGRLIDFL NGNFIRMSCG GMILETKKAC EDSVTLNAVG PVDLAVVTKY LDWWKRTGLL
     HPVNRE
//
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