ID A0A0B4HVZ0_METMF Unreviewed; 1507 AA.
AC A0A0B4HVZ0;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
DE Flags: Fragment;
GN ORFNames=MAJ_00092 {ECO:0000313|EMBL:KIE03561.1};
OS Metarhizium majus (strain ARSEF 297).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium;
OC Metarhizium majus.
OX NCBI_TaxID=1276143 {ECO:0000313|EMBL:KIE03561.1, ECO:0000313|Proteomes:UP000031176};
RN [1] {ECO:0000313|EMBL:KIE03561.1, ECO:0000313|Proteomes:UP000031176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 297 {ECO:0000313|EMBL:KIE03561.1,
RC ECO:0000313|Proteomes:UP000031176};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIE03561.1}.
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DR EMBL; AZNE01000001; KIE03561.1; -; Genomic_DNA.
DR RefSeq; XP_014582554.1; XM_014727068.1.
DR HOGENOM; CLU_002210_0_0_1; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000031176; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000031176};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 8..376
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1011..1183
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1192..1496
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 97..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1359..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KIE03561.1"
SQ SEQUENCE 1507 AA; 163987 MW; 8FCFC9B127795826 CRC64;
MDAAEYDTNI LVVNNIASIS FRVYEPSSDQ SSSFGLAAID IENSLREKGH IVYYDASRRG
IWHFRIVGKE GSDEVSSQEL DSSLSLRGYS LIVGEEGSFE PSSLPRPRSQ QPQTGHTPTS
STSSASALDQ SQRYAPTATS HLGPPGLQEQ DSKGHTSVTD AKLVQGGSSS PKAYESFVVA
TLLTIQSAFC RHTDSIPLNY RTVLLSQNIL ENDGSFDVVT EKTPTIGTFS AYLTTTGVLV
VCMGISICRG LLSYGDMLNQ APDLPGQQIL AAPFGVIASN QPAAQFDGTA SMAQTPNTQA
LSLRGAPDIH NSFWKQACLK FLQLRGVAQS KLTDCFWINL LISKPKLQDA KSDVKRSPMP
NSTVTIPWPS PLCFRKRPVE VSSTSRVGET ILRGHEESHD PLGNAQSWFS STPERDEKIS
KRKAERVATS SEGFGGDSRP TRLNGQSPLT LRRPSTAAAG SMYPTPPDAL QNANGVTPSL
DGTLSSPGNP LSAAAVPEGD NNGSVSMAMG DSFEPVRDFS EPKRQRSDSN LLGEADHMFG
DMGQDMFGDN DITEADFNFF DEEPEDIDLE AALDEMGDAT TAAIIGAEEH IADEEISNSR
EPIKEEPEAE KDAGGFTKPE LRHAISAQND HAMPRGRESR PVSMKRESSP FDPHTVFKRV
CASLAATEKD GTIATDTNRM TKIFEKMDFD PTLPMINKKY EQGGQFDYSM STAVGNSRLD
HGVLPETDYL KRHGKLHRGS QEHKLYTKSL MGPLSGLEQP NSGRSPTKLD TQMSDDEQSS
TESDQDDSSY TSDEPTSPPK SSVKQAPVEE DAVSQVTSLK EQDVIEEPDH QLAIELPRLS
KPETPELPLS MLFLDPEPLA LELSLGDEDL IQTAQILTEQ AATGSLDLCC NTDHPPNSSI
LSQGRATLLS NARTARQQLR EALSVFLRGA EPVRLKAFLD IQDVLLQGQP RMQPRPIPGR
DANAEQIRPS NLYQIPGPHL EVRRSDAKLS VLPSAVAFWE SLGLAPSSGS KDITAVCVFP
GWKGMADNAK TFLGRIKSVY EVLRLGSFEN MALASDMGSG VLPYEMDRIS TSPDATLTGH
GSALIGTMET LRASLSNLTV SDTNVVVYFV YSPNNPGTIV EACAAFQRFF DSYQKDLAAK
KETATNELVL QLVSSDLLSS PTSVVVTPSV DLVRLCMETY DRCTLFGGPM PAPAIRLEQP
LPRIIDFKLS TQPSVSLIRE NSCIHVAYAQ TVDGRWVTTA WTDDRGNQQA TASYCLGRKG
RPLSTSMSEV AHEIWQSTLD LISAWTVHWR VIITKCGPMD QQEIDSWVNL AHTETRLQVT
MILMTVDTDP WLQLVPPVVK LPHLSAPFYT TPVSTPQANI VSPEQSATPA TPANVTAATP
GGGEAGADTE TDAILADVTD QTWGAIVGHR LNNSLGVTDL YPALVSGFLI KRTGARAEDV
PIAMEVNLIH TEAFPRSYEP LLREMLSYFR GLATLSRARG MVSRETDVRP WHIAAAEKAA
RAMYLLM
//
