ID   A0A0B4I2B1_METMF        Unreviewed;       539 AA.
AC   A0A0B4I2B1;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
DE   Flags: Fragment;
GN   ORFNames=MAJ_07212 {ECO:0000313|EMBL:KID96826.1};
OS   Metarhizium majus (strain ARSEF 297).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium;
OC   Metarhizium majus.
OX   NCBI_TaxID=1276143 {ECO:0000313|EMBL:KID96826.1, ECO:0000313|Proteomes:UP000031176};
RN   [1] {ECO:0000313|EMBL:KID96826.1, ECO:0000313|Proteomes:UP000031176}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 297 {ECO:0000313|EMBL:KID96826.1,
RC   ECO:0000313|Proteomes:UP000031176};
RX   PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA   Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA   St Leger R.J., Wang C.;
RT   "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT   adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KID96826.1}.
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DR   EMBL; AZNE01000043; KID96826.1; -; Genomic_DNA.
DR   RefSeq; XP_014575820.1; XM_014720334.1.
DR   AlphaFoldDB; A0A0B4I2B1; -.
DR   HOGENOM; CLU_014393_4_0_1; -.
DR   OrthoDB; 5481886at2759; -.
DR   UniPathway; UPA00109; UER00180.
DR   Proteomes; UP000031176; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.40.367.20; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   PANTHER; PTHR19443:SF29; PHOSPHOTRANSFERASE; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362007};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031176};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT   DOMAIN          13..248
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          262..529
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
FT   REGION          97..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KID96826.1"
SQ   SEQUENCE   539 AA;  58376 MW;  867F8BBB78D4D404 CRC64;
     MASTPEQLAL LGAFLEPMSI DVQKCHVLSE RFLQNFTHLS AESLDQFLPT PISESILRPV
     EDYGHGRHLA IDIGGTNLRV GFVELLTVES AISASHGATT TSNGINGING TTSSSTEDQA
     VPTLPTGRLH RQLEKSWPIS NHLKSDNADS LFLWIGKCIA EVVEEGCKAF NLSIETPLPL
     GITFSFPVEQ PSLEKAIISS MGKGFAIPPH VDLGIRLQAA YDKHRGDNLP PIYVAAIAND
     SVSTLISFIF NYDRLAHRRA AMGLILGTGS NATIPVKLSL LHPSKWPKNV NVLPGEKVED
     AKIAVNTEWS INGTAPPMRE LGLISGWDDE LSAKNEKPGF QPLEYMTAGR YLGELGRIML
     VDYMTSRLNV GRDLLPPKIL EPDSLTTTFL SHFKPLQPTT LLSTLKTEFP EPSGSQFVWT
     EHHAEALYRI SKAIEVRAAG IIAAAILALL TLGEEIPVDG ASPIPTSEIR ELGVGYTGGC
     IVHFQDYLVD CQHFVDQLVK KRCGNDFPLR VTLNPCHDGG ITGAGILVAA ALSSQASQT
//