ID A0A0B4I417_METMF Unreviewed; 1028 AA.
AC A0A0B4I417;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|RuleBase:RU366037};
DE Flags: Fragment;
GN ORFNames=MAJ_01066 {ECO:0000313|EMBL:KIE02764.1};
OS Metarhizium majus (strain ARSEF 297).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium;
OC Metarhizium majus.
OX NCBI_TaxID=1276143 {ECO:0000313|EMBL:KIE02764.1, ECO:0000313|Proteomes:UP000031176};
RN [1] {ECO:0000313|EMBL:KIE02764.1, ECO:0000313|Proteomes:UP000031176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 297 {ECO:0000313|EMBL:KIE02764.1,
RC ECO:0000313|Proteomes:UP000031176};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease. {ECO:0000256|ARBA:ARBA00025147}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|ARBA:ARBA00009466, ECO:0000256|RuleBase:RU366037}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIE02764.1}.
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DR EMBL; AZNE01000003; KIE02764.1; -; Genomic_DNA.
DR RefSeq; XP_014581757.1; XM_014726271.1.
DR AlphaFoldDB; A0A0B4I417; -.
DR HOGENOM; CLU_004414_0_1_1; -.
DR OrthoDB; 2546268at2759; -.
DR Proteomes; UP000031176; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000031176};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 110..268
FT /note="Exportin-1/Importin-beta-like"
FT /evidence="ECO:0000259|Pfam:PF08389"
FT DOMAIN 343..1026
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
FT COILED 423..450
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KIE02764.1"
SQ SEQUENCE 1028 AA; 114836 MW; 583F8EF8A20C0949 CRC64;
MSFSSSCLQV ENAVEILSNP TSNQSVKEQA FEYLNQLRSD PQGWQACTNL FSRAPRSSEV
VRMVCLEVVN YAVHTQGLDA ESLSYLKYTL LQYVRQSYGP DAQQEPDPAS LQNKLTQTLT
YLFVFLYQDG WQSFLDDFWG LTGLPSNRDS VSGVLFYLRI LSSIHDEIAD MLLSRQSNDA
KRNTELKDQL RAQDVHKVAE SWKQILNKYG DNDAVIELVL KVIGKWVSWM DISLVVSQDM
INLLLPLVGR TTSGGGEDKV RDAAIDTLTE ICGKKMRSAD KMGLVSFLNL QDIVGQLIAS
APLSTHKGTS KYDTDLAEAV AKLVNTVMSD IVKALDDNHI GEESRERAKQ HLHGFLPFLL
RLFSDEYDEV CSTIIPALTD LLTFLRKLGQ LPQDYSSMLA PILDAIIRKM RYDETSTWGN
EDEQTDEAEF QELRRKLQNL QKTIAAIDQQ LYMNMLSNLV ASTFQTLDQR GSEMDWRDLD
LALYEMYLFG ELALPNQGLG TKNQPSTEAS ERLVVMMQKM VGSGIANFSH PAILLQYMEI
CVRYCIVFES HPDYIPQVLE NFVRLVHHDH VRIKTRSWYL FHRFIKQLRS QVGNVAETVI
HSIGDLLPIK AEVPGEDADD DMSSDESDHS ADALFNSQLY LFEAIGCISS THSTPADKQA
MYARSVMDPL FQDMEVHLPR AKSGDAQAVL QIHHIVMALG TLAHGFSDWS PGSAATSHHP
PPAKAVSDEF SRAAEAILIA LNQLNSSAEI RTACRSAFSK LLGVLGSAVL PQLPQWIEGL
LSQSSSKDEM AMFLRLLDQV VFGFKAEIYD VLNVLLTPLL QRIFGGLSEP ISGTDDEIQL
AELRREYLSF LQIILNNGLD GVLISEANQG FFEPMISSIT ELAKTLDGNI GPSRLAFTLM
ARISAIWGGP DVATISQNPV APTTSPAPAI PGFDRFMLDR FHSVCWEVMR NPSFRPAQDA
QTRQVLTEIA GLEQTIYTKT GDVFIQELQN GLFPTLGING DEFLRSLTTS TDKKGFSSYL
QGLLKNRR
//
