ID A0A0B4I5B9_METMF Unreviewed; 1178 AA.
AC A0A0B4I5B9;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=DUF726 domain protein {ECO:0000313|EMBL:KIE03314.1};
DE Flags: Fragment;
GN ORFNames=MAJ_00828 {ECO:0000313|EMBL:KIE03314.1};
OS Metarhizium majus (strain ARSEF 297).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium;
OC Metarhizium majus.
OX NCBI_TaxID=1276143 {ECO:0000313|EMBL:KIE03314.1, ECO:0000313|Proteomes:UP000031176};
RN [1] {ECO:0000313|EMBL:KIE03314.1, ECO:0000313|Proteomes:UP000031176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 297 {ECO:0000313|EMBL:KIE03314.1,
RC ECO:0000313|Proteomes:UP000031176};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- SIMILARITY: Belongs to the TMCO4 family.
CC {ECO:0000256|ARBA:ARBA00009824}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIE03314.1}.
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DR EMBL; AZNE01000002; KIE03314.1; -; Genomic_DNA.
DR RefSeq; XP_014582307.1; XM_014726821.1.
DR AlphaFoldDB; A0A0B4I5B9; -.
DR HOGENOM; CLU_001695_1_0_1; -.
DR OrthoDB; 8526at2759; -.
DR Proteomes; UP000031176; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920:SF24; LIPASE MIL1-RELATED; 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031176};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 591..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 938..969
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 63..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1006
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1072
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KIE03314.1"
SQ SEQUENCE 1178 AA; 128387 MW; 70BD429075C7A05B CRC64;
MVSNKDVEPD DATNPKASQA PVPTPAQHET DDFGLPIRRY IAPTNDATLP KPDVGADNVM
TTSEPADEVN NQTKDADSST PAPELKDQKP STSSAGSKDS NRAAESGSES DDAPFVDARS
AMPATSSVAS AREPAVLTSG AQTQTAEPEK EVEEKDHTSM STPTVSPDET AARGAQTPKP
ESEKADPVAN GTKPPVSDEK QAEGTATSSE QTNENPNISH TRDVSAVSIG SGPQPVLSEF
SHQQLSTQHQ DEKEEDDGGW QTMPAFAPYD IYDDDNRLIA REHNEEEDEK YGYSGLGGAG
KGYTRVIMDE DAESATSLDD NTQYLFQESK KGTGLADDEG RDAVAQMQAT KDLLTEGQRI
AYVGVVRLEI AKMVKEAEDL EVTKKIKKLV NMSAESEKMW GQKMMIRLYS HMDISEAEQV
MIEQLAEHGV MPKDLTPALH ANSRVHNPMA EDRTSVDKST GSTSVSPGPP TPNDEKPAEM
PPPYESIDHS EVPDAQTPSQ LPTTEKIDID LRWTVLCDLF LILIADSIYD ARSRVLLERV
ADSLEISWID ICKFEKRVTD ALEMQQAAEK ENWNEEEHME SRRKQAQKRR YMMMGLATVG
GGLVIGLSAG LLAPVIGAGL AAGFTTIGVT GTSSFLAGAG GAAIITSSAA ASGSVIGGRA
ANRRTGAVKT FEYRPLHNNK RVNLIVTVSG WLTGKVDDVR LPFSTVDSVM GDIYSVLWEP
EMLRSMGDTI NILATEALTQ GLQQILGSTI LMSLMAALQL PIVLTKLSYL IDNPWAVSLD
RATAAGLILA DSLMDRSLGT RPITLVGYSL GARVIFSCLQ ELAKRGAYGL VQNIYLFGSP
IVVKKEEFVR ARTVVSGRFV NGYNRNDWIL GYLFRLTNGG IRRIAGLAPV EAPWVENIDV
TEEVPGHMQY RTAMPTLLIK CGWVVESEEF TEIEDPDPDN HEERQRELIN EIEEARKELE
REGKAKKSGR FSLFGRRKKA DRQEWEVYEE SAAKGGKEDG NGGKVEDKIG NNHGVLFDVD
AIRAELAKES HGDADVETAL QVKEIESTLP PMKLDICPTT PSLSSPIADG RSSLRETRSA
DILTVGRMGF GSPNGSRDLS PYHTNMHEEE VQMTFDTSFD DSAHTHTQAA PSTNGESSLT
RPEMKSSQTL PNMTISDPWA DPEDEDFGKE KEISMTFA
//
