ID A0A0B4I6V2_METMF Unreviewed; 510 AA.
AC A0A0B4I6V2;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=sphingolipid C(9)-methyltransferase {ECO:0000256|ARBA:ARBA00039020};
DE EC=2.1.1.317 {ECO:0000256|ARBA:ARBA00039020};
DE Flags: Fragment;
GN ORFNames=MAJ_05352 {ECO:0000313|EMBL:KID98696.1};
OS Metarhizium majus (strain ARSEF 297).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium;
OC Metarhizium majus.
OX NCBI_TaxID=1276143 {ECO:0000313|EMBL:KID98696.1, ECO:0000313|Proteomes:UP000031176};
RN [1] {ECO:0000313|EMBL:KID98696.1, ECO:0000313|Proteomes:UP000031176}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 297 {ECO:0000313|EMBL:KID98696.1,
RC ECO:0000313|Proteomes:UP000031176};
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SIMILARITY: Belongs to the CFA/CMAS family.
CC {ECO:0000256|ARBA:ARBA00010815}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KID98696.1}.
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DR EMBL; AZNE01000022; KID98696.1; -; Genomic_DNA.
DR RefSeq; XP_014577690.1; XM_014722204.1.
DR AlphaFoldDB; A0A0B4I6V2; -.
DR HOGENOM; CLU_026434_5_0_1; -.
DR OrthoDB; 5484439at2759; -.
DR Proteomes; UP000031176; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR45197:SF1; SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED; 1.
DR PANTHER; PTHR45197; SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED; 1.
DR Pfam; PF02353; CMAS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031176};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 53..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 82..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KID98696.1"
SQ SEQUENCE 510 AA; 57242 MW; 08937D415B7D4B2B CRC64;
MKNKPDLEGD ITYIKTPEAA PSAFEAVDCG VPITHSPSIH NAPLPAEGAG SESFSNIVLG
VLLVGVPYFL SRFVGGGLKT TVFFGILTLF PILIAYWAYT SNFSPRINEH VKLPGRPVES
YVTFKDAADQ ARWSGANKVP IQTFSEMYID GKADFKGDVL DVLEYRHDWS RFSFTWDLFK
YILLTFGPDV LFHTKDQDME QIRPNYDSGN DHYAWFLGPR MIYTSGIISD TTREETLEEL
QDNKMAVVCE KLELKEGETL LDIGSGWGTL AKFASVNYGA KVTGITIAEN GAAWGNDVLR
NAGVPEEQSR ILCMDYRDAP KQKYDKISQL EMGEHVGVRK LTTFFRQCYD MLEDDGAMYV
QLSGLRQAWQ YEDFIWGLFL NKYIFRGADA STPLWNYVRS LESAGFEVKS VDTVGVHYSA
TLWRWYRNWV GNGDAIKAKY GQRWYRIWEL FLAWSVIASR QGSATCFQIL VVKNLNSVHR
INGVGSQFGL SGALATSRAA GKASLSPSKI
//
