ID A0A0B4J1R0_HUMAN Unreviewed; 160 AA.
AC A0A0B4J1R0;
DT 04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT 04-MAR-2015, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Chorionic somatomammotropin hormone like 1 {ECO:0000313|Ensembl:ENSP00000259003.10};
GN Name=CSHL1 {ECO:0000313|Ensembl:ENSP00000259003.10};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000259003.10, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000259003.10, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000259003.10}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU003618}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000256|ARBA:ARBA00008474, ECO:0000256|RuleBase:RU003618}.
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DR EMBL; AC127029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001307997.1; NM_001321068.1.
DR AlphaFoldDB; A0A0B4J1R0; -.
DR SMR; A0A0B4J1R0; -.
DR MassIVE; A0A0B4J1R0; -.
DR PeptideAtlas; A0A0B4J1R0; -.
DR Antibodypedia; 31484; 190 antibodies from 23 providers.
DR DNASU; 1444; -.
DR Ensembl; ENST00000259003.14; ENSP00000259003.10; ENSG00000204414.14.
DR GeneID; 1444; -.
DR CTD; 1444; -.
DR HGNC; HGNC:2442; CSHL1.
DR VEuPathDB; HostDB:ENSG00000204414; -.
DR GeneTree; ENSGT00950000182818; -.
DR OrthoDB; 5344007at2759; -.
DR BioGRID-ORCS; 1444; 14 hits in 1129 CRISPR screens.
DR GenomeRNAi; 1444; -.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000204414; Expressed in placenta and 26 other cell types or tissues.
DR ExpressionAtlas; A0A0B4J1R0; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031982; C:vesicle; IEA:UniProt.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417:SF67; CHORIONIC SOMATOMAMMOTROPIN HORMONE 1-RELATED; 1.
DR PANTHER; PTHR11417; SOMATOTROPIN,PROLACTIN; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hormone {ECO:0000256|RuleBase:RU003618};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601400-1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0B4J1R0,
KW ECO:0007829|ProteomicsDB:A0A0B4J1R0};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|PIRSR:PIRSR601400-1}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..160
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002092588"
FT BINDING 143
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR601400-1"
SQ SEQUENCE 160 AA; 18235 MW; C2AC558E00594113 CRC64;
MAAGSRTSLL LAFALLCLPW LQEADSIPTS SNMEETQQKS NLELLHISLL LIESRLEPVR
FLRSTFTNNL VYDTSDSDDY HLLKDLEEGI QMLMGRLEDG SHLTGQTLKQ TYSKFDTNSH
NHDALLKNYG LLHCFRKDMD KVETFLRMVQ CRSVEGSCGF
//
