ID A0A0B4K700_DROME Unreviewed; 2082 AA.
AC A0A0B4K700;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Mini spindles, isoform D {ECO:0000313|EMBL:AFH06447.1};
GN Name=msps {ECO:0000313|EMBL:AFH06447.1,
GN ECO:0000313|FlyBase:FBgn0027948};
GN Synonyms=anon-WO0140519.136 {ECO:0000313|EMBL:AFH06447.1}, Dis1
GN {ECO:0000313|EMBL:AFH06447.1}, Dmel\CG5000
GN {ECO:0000313|EMBL:AFH06447.1}, MSPS {ECO:0000313|EMBL:AFH06447.1},
GN Msps {ECO:0000313|EMBL:AFH06447.1}, TOG {ECO:0000313|EMBL:AFH06447.1},
GN XMAP215 {ECO:0000313|EMBL:AFH06447.1};
GN ORFNames=CG5000 {ECO:0000313|EMBL:AFH06447.1,
GN ECO:0000313|FlyBase:FBgn0027948}, Dmel_CG5000
GN {ECO:0000313|EMBL:AFH06447.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AFH06447.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AFH06447.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AFH06447.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AFH06447.1, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AFH06447.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AFH06447.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AFH06447.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AFH06447.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AFH06447.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR EMBL; AE014297; AFH06447.1; -; Genomic_DNA.
DR RefSeq; NP_001247129.1; NM_001260200.2.
DR DNASU; 41952; -.
DR EnsemblMetazoa; FBtr0304801; FBpp0293341; FBgn0027948.
DR GeneID; 41952; -.
DR AGR; FB:FBgn0027948; -.
DR CTD; 41952; -.
DR FlyBase; FBgn0027948; msps.
DR VEuPathDB; VectorBase:FBgn0027948; -.
DR GeneTree; ENSGT00390000014757; -.
DR OMA; NWKERKE; -.
DR OrthoDB; 5477703at2759; -.
DR PhylomeDB; A0A0B4K700; -.
DR BioGRID-ORCS; 41952; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 41952; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0027948; Expressed in eye disc (Drosophila) and 53 other cell types or tissues.
DR ExpressionAtlas; A0A0B4K700; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0099080; C:supramolecular complex; IEA:UniProt.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 4.
DR SMART; SM01349; TOG; 5.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0B4K700};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..227
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 268..507
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 440..478
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 579..812
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 850..1085
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1177..1413
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 506..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2082 AA; 230405 MW; 1C60724C78F5D162 CRC64;
MAEDTEYKKL PVEERCVHKL WKARVDGYEE AAKIFRELDD EKSPEWSKFA GLIKKMVVDS
NALAQEKGLE AALIFVENSG LAGRTVGDVM TGIVQKCIAA PKTKTKELSV QVALMYVEIE
KQEAVVEELV KGMEAKNPKI VSACVAATTL ALREFGHKVI GVKPLIKKLA PLMSDRDKTV
RDEGKQLAVE IYRWIGAAMK AQISTLPQVT LKELEDEFDK LKGERVEPSR YLKSQQEKQA
KIADAAATED AYNEDDGEAG VEEIDPMDLL DPVDILSKMP KDFYDKLEEK KWTLRKESLE
VLEKLLTDHP KLENGEYGAL VSALKKVITK DSNVVLVAMA GKCLALLAKG LAKRFSNYAS
ACVPSLLEKF KEKKPNVVTA LREAIDAIYA STSLEAQQES IVESLSNKNP SVKSETALFI
ARALTRTQPT ALNKKLLKLL TTSLVKTLNE PDPTVRDSSA EALGTLIKLM GDKAVTPLLA
DVDPLKMAKI KECQEKAEIK IKVAGPKKET RPASAPTAKA AAPAKTVAGS VDPKPVTRPA
TTGARKVLKK PATVSGGGAT SAPTAALKAG GKPLATEREI TPEELQEKSE EILPAEILNG
LVDSNWKNRL AAVEQLLGEI SGFDAKQAGI SQILIRTISG RKPGLKEMNF QVLKFKLDII
RSVAENYPLT TTTVDLVINE IIEKLADAKN GAAAADVLSA FAEATKLEYV VGKVLSFAFE
QKSPKVQSEA FNWVNRSIIE FGFQLQPKTL IEDVRKGVQS TNPTVRASAI QMVGTMSMYM
GKALMMFFDS EKPALKSQIQ VEFDKNVGEK PPKPVRGVQR SSGGTAGNSP DNEDDDGGAA
GEEEPINMAD LLPRVDIAPQ ITEALLKEMS DKDWKTRNEG LTKLQAIISE ARLIKPSIGD
LAPALAHRLV DSNAKIAQTT LAICEQLATA MGAGCRNHVR NLFPGFLHAL GDNKSFVRAA
ALNCINSFGE KGGYKEFFES EMIADALKGG SPALKTELWA WLADKLPGLP PKSVSKEDIH
SMVPHLYAHI CDRNADVRKN ANEAVLGIMI HLGFDAMNRA LDKQKPASKK DILAALEKAR
PNLPVKPLPK GKHQAPIPEE PKLKTVRGGG AGGAPGIQKS ATARVAGGQD KQVPARKKDE
DIDTSPLLCA NSAKNQRLLD EQKMKVLKWT FVTPREEFTE LLRDQMMTAN VNKALIANMF
HDDFRYHLKV IEQLSEDLAG NSKALVCNLD LILKWLTLRF YDTNPSVLIK GLEYLVQVFQ
VLIDEEYILA ENEGSSFVPH LLLKIGDPKD AVRNGVRRVL RQVILVFPFV KVFGYVMEGL
KSKNARQRTE CLDELTFLIE SYGMNICPQS AVREIARQIS DRDNSVRNAA LNCIVQVFFL
SGEKTYKMIG HLNEKDLSML DERIKRAKKT KKPTPPPSVD VPAPQRHDSI EIEDAEVGNG
CDELPPPDED GLQRELNARG QNNMTDRSAT NVVAYLSSLT RQATFDQAPS SQLLLLQQQL
QQLQQQAQQQ KPSGPFGLDS QVISEIEKDW VRVDQMEQKP LLNVDISSLD EPIKVRPTRA
GIHYPQEKFD RLISRQHYMQ QTLTTSPSST AGMTSGVSPY RSPMRLQHQQ PQQQLENNIP
NLADVLPKHD PQLVKVIKGV SSTDTLKARA AINELAAIIE APEKQAVLRD YEEIFIQNVL
AQFKNLSQIP SAQSVVVYQP LLSILYTFFH ANILGKTLSV ACIKNLMSAL LNLMADPKLA
VGDDSQYNKV INGICLKVLD KVDFTNLNCA LIRLLRETCP EAKLPKFTDL LMKCIWRNVK
MLPERSNELN YDAVILEVHE FMLALPSTWW QNRPSDTPMR TIKTILHNMA KVKGNAILQH
LNQIPTHSEL HTYLIRILKN FQKDGSASGI GASPQRAKEI ASKRISHQTH DTVSQIFKLI
SDRDTKQQGL QKLYDFKQQN PDIDLSTFLQ GSSAPFHKYI EEGLAEIERN QNAGSTQDNR
TAATRSYLTD VNYQNNGPDP DFWMDRLQYH MTGGAAKLAS ARSADDGSHM LDNKVVDENL
CLNGMNAQKA SLIKREKRDM SPNRLQHLQA KLAQIKKENH AQ
//