ID A0A0B4KFN0_DROME Unreviewed; 160 AA.
AC A0A0B4KFN0;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Transcription initiation factor TFIID subunit 12 {ECO:0000256|ARBA:ARBA00017484};
GN Name=Taf12 {ECO:0000313|EMBL:AGB95861.1,
GN ECO:0000313|FlyBase:FBgn0011290};
GN Synonyms=d28/22 {ECO:0000313|EMBL:AGB95861.1}, Dmel\CG17358
GN {ECO:0000313|EMBL:AGB95861.1}, dmTAF12 {ECO:0000313|EMBL:AGB95861.1},
GN dTAF12 {ECO:0000313|EMBL:AGB95861.1}, dTaf12
GN {ECO:0000313|EMBL:AGB95861.1}, dTAF22 {ECO:0000313|EMBL:AGB95861.1},
GN dTAF28 {ECO:0000313|EMBL:AGB95861.1}, dTAF[[II]]30
GN {ECO:0000313|EMBL:AGB95861.1}, dTAF[[II]]30alpha
GN {ECO:0000313|EMBL:AGB95861.1}, dTAF[[II]]30alpha/22
GN {ECO:0000313|EMBL:AGB95861.1}, dTAFII30 {ECO:0000313|EMBL:AGB95861.1},
GN dTAFII30 alpha {ECO:0000313|EMBL:AGB95861.1}, p22
GN {ECO:0000313|EMBL:AGB95861.1}, p28 {ECO:0000313|EMBL:AGB95861.1},
GN T2DA_DROME {ECO:0000313|EMBL:AGB95861.1}, TAF
GN {ECO:0000313|EMBL:AGB95861.1}, TAF12 {ECO:0000313|EMBL:AGB95861.1},
GN taf12 {ECO:0000313|EMBL:AGB95861.1}, Taf22
GN {ECO:0000313|EMBL:AGB95861.1}, Taf28 {ECO:0000313|EMBL:AGB95861.1},
GN TAF30a {ECO:0000313|EMBL:AGB95861.1}, TAF30alpha
GN {ECO:0000313|EMBL:AGB95861.1}, Taf30alpha
GN {ECO:0000313|EMBL:AGB95861.1}, TAF30alpha/28
GN {ECO:0000313|EMBL:AGB95861.1}, TAF30alpha/28/22
GN {ECO:0000313|EMBL:AGB95861.1}, Taf32 {ECO:0000313|EMBL:AGB95861.1},
GN TAF[[II]] {ECO:0000313|EMBL:AGB95861.1}, TAF[[II]]230
GN {ECO:0000313|EMBL:AGB95861.1}, TAF[[II]]30alpha
GN {ECO:0000313|EMBL:AGB95861.1}, Taf[[II]]30alpha
GN {ECO:0000313|EMBL:AGB95861.1}, TAF[[II]]30alpha/28/22
GN {ECO:0000313|EMBL:AGB95861.1}, TAF[II]30alpha
GN {ECO:0000313|EMBL:AGB95861.1}, TAFII30alpha/22
GN {ECO:0000313|EMBL:AGB95861.1}, TFIID {ECO:0000313|EMBL:AGB95861.1},
GN TFIID 22 {ECO:0000313|EMBL:AGB95861.1}, TFIID 28
GN {ECO:0000313|EMBL:AGB95861.1}, TFIID-p28
GN {ECO:0000313|EMBL:AGB95861.1};
GN ORFNames=CG17358 {ECO:0000313|EMBL:AGB95861.1,
GN ECO:0000313|FlyBase:FBgn0011290}, Dmel_CG17358
GN {ECO:0000313|EMBL:AGB95861.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB95861.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AGB95861.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AGB95861.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AGB95861.1, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AGB95861.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AGB95861.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AGB95861.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AGB95861.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AGB95861.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF12 family.
CC {ECO:0000256|ARBA:ARBA00007530}.
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DR EMBL; AE014297; AGB95861.1; -; Genomic_DNA.
DR RefSeq; NP_001262479.1; NM_001275550.1.
DR RefSeq; NP_731617.2; NM_169421.3.
DR AlphaFoldDB; A0A0B4KFN0; -.
DR SMR; A0A0B4KFN0; -.
DR DNASU; 41406; -.
DR EnsemblMetazoa; FBtr0290205; FBpp0288644; FBgn0011290.
DR EnsemblMetazoa; FBtr0335213; FBpp0307200; FBgn0011290.
DR GeneID; 41406; -.
DR AGR; FB:FBgn0011290; -.
DR CTD; 6883; -.
DR FlyBase; FBgn0011290; Taf12.
DR VEuPathDB; VectorBase:FBgn0011290; -.
DR OrthoDB; 22237at2759; -.
DR BioGRID-ORCS; 41406; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41406; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0011290; Expressed in brain and 24 other cell types or tissues.
DR ExpressionAtlas; A0A0B4KFN0; baseline and differential.
DR GO; GO:0000124; C:SAGA complex; IEA:InterPro.
DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:InterPro.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR CDD; cd07981; TAF12; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037794; TAF12.
DR InterPro; IPR003228; TFIID_TAF12_dom.
DR PANTHER; PTHR12264; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12; 1.
DR PANTHER; PTHR12264:SF21; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12; 1.
DR Pfam; PF03847; TFIID_20kDa; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 57..124
FT /note="Transcription initiation factor TFIID subunit 12"
FT /evidence="ECO:0000259|Pfam:PF03847"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 160 AA; 17630 MW; E3517F6FC3CA3FAE CRC64;
MASPSQHSPM TNNSNSSSQN GGPVSGLGTG TGPISGGSKS SNHTSSAAGS ENTPMLTKPR
LTELVREVDT TTQLDEDVEE LLLQIIDDFV EDTVKSTSAF AKHRKSNKIE VRDVQLHFER
KYNMWIPGFG TDELRPYKRA AVTEAHKQRL ALIRKTIKKY
//
