ID A0A0B4KH30_DROME Unreviewed; 2042 AA.
AC A0A0B4KH30;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Kramer, isoform G {ECO:0000313|EMBL:AGB95930.1};
GN Name=kmr {ECO:0000313|EMBL:AGB95930.1,
GN ECO:0000313|FlyBase:FBgn0085412};
GN Synonyms=CG14365 {ECO:0000313|EMBL:AGB95930.1}, CG14366
GN {ECO:0000313|EMBL:AGB95930.1}, CG9322 {ECO:0000313|EMBL:AGB95930.1},
GN Dm_3R:52023 {ECO:0000313|EMBL:AGB95930.1}, Dmel\CG34383
GN {ECO:0000313|EMBL:AGB95930.1}, PLEKHA4 {ECO:0000313|EMBL:AGB95930.1};
GN ORFNames=CG34383 {ECO:0000313|EMBL:AGB95930.1,
GN ECO:0000313|FlyBase:FBgn0085412}, Dmel_CG34383
GN {ECO:0000313|EMBL:AGB95930.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB95930.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AGB95930.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AGB95930.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AGB95930.1, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AGB95930.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AGB95930.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AGB95930.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AGB95930.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AGB95930.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
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DR EMBL; AE014297; AGB95930.1; -; Genomic_DNA.
DR RefSeq; NP_001262548.1; NM_001275619.2.
DR SMR; A0A0B4KH30; -.
DR EnsemblMetazoa; FBtr0329897; FBpp0302931; FBgn0085412.
DR GeneID; 5740131; -.
DR AGR; FB:FBgn0085412; -.
DR CTD; 5740131; -.
DR FlyBase; FBgn0085412; kmr.
DR VEuPathDB; VectorBase:FBgn0085412; -.
DR BioGRID-ORCS; 5740131; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG34383; fly.
DR GenomeRNAi; 5740131; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0085412; Expressed in embryonic dorsal epidermis (Drosophila) and 57 other cell types or tissues.
DR ExpressionAtlas; A0A0B4KH30; baseline and differential.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR PANTHER; PTHR12752:SF9; KRAMER, ISOFORM I; 1.
DR PANTHER; PTHR12752; PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 393..492
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 68..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1106..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1552..1575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1661..1680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1704..1782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1849..1876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1990..2012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1398..1491
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 68..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..615
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..900
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1704..1723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2042 AA; 227381 MW; 5DBF0443978DAF71 CRC64;
MFGCIYQLWD WLEAPPLFTA GTMDAKKLQQ LQEAAILAQQ QKKLPLAYQT NLVDYRTAAY
SQALYQQSPT ATSSSGGGPL SPIDMQPQSK HYNLMKHGGG TSSSSHSSPY HQSYSSSGGT
AAGEQLYQSP TERTYLAAAG RLHANNAMAG HHPISALQSQ YQQLQAAKMQ AQMATQSEAA
QQQQRTFALR QAMNPPTNHY HMSQSSSMVS TMTALNQQQQ QQQQQQQQQQ QQQRAPPSSL
NLQNQYQPAQ GPLKLQQQQQ QQQQQSQQPA MPKHYQEQLY AQQQQLQQQL HQQQQQQQQL
QQQQQQHRHK NDLQTPGSEH GTVYIQQNHP NHVVNQACQT QISAVKPKAT PSSEESSSNS
TKSPSHAPLD RKKSAGSIQA LKSPITKRPP STPVTLSGWL HKQGSDGLKV WRKRWFVLAE
YCLYYYKGPE EEKLLGSVLL PSYRVSACLP EDKIYRKFAF KCEHQNMRTY WLAADNSEAM
MQWVRALAAA SLMQAPSSGE SEPSVNSSLN HSGENSDSGI HTLQSHPGKG QPTPSSENTG
SSGGGSGSGQ PLYANAPPKP RRINDGGYSS PSPEHNEQQQ QHPSRRLMSP TQQLYQQQQH
QRSQQQQQQQ PQQHHAIYDT RTGHVSTALQ LQQAQQQYSL DHLEAQFQQQ QLDMEEQIAR
LQQQRAAEEI YGEREMYMAK LMQQRQGPNG TYPTQQQLLQ AERRTPDAYG RSKQQRLFAA
AAAAADYEDI YNMSQLAGGG GVPMSAQEAL LQEAASYRRP LSPPSYDGSK HVPAMPQRYT
PNHLEASAAD QLINTMDLRA RTAAAIVRPH SADFLEYEAR AEAAAAAAAA AVAQSQQESG
RAPRPKSSLD INRTPDSFYY SEASYADKMR KSALYLQSGG AGAAQPQQPG SYRTTGADFN
SGVNTIGYEN PYERAYKRQE LLAEAQGGGA SSMPRMSRSA SQGRSVASQL QSPQQEDLPP
LNVHPGSIFP PSMSTQEIIS KNEQFLRSAS ARLPKRSGGM DDDYSAGNST TTSPTGGAGA
SNSPQHNLDG ERKREESMKR LLEWKQRMLQ SPLTRKGIQQ GGSNMSAMSK LGSNPNILLA
STAVASGARY APQAGKTVLV GNGNGTAQGA GNPPSASGIQ RSRSESQANV GPGGVVYNNY
SSDDEASISV RNVNNLPVGN LTVKPDPSDV HQESAFAPYY GGAAETKYAK NTVLTDRGLY
AANGSGLATS TPQNHQQFRM RHTGSRAEID MLERETSSQI RNLDVSAGDL LSRTHEELVL
LLIQLRRQSS QTARAIEQCC SDIHDVQNRL RSAEGLTRAE SIQRLDYLKQ HLLDLERHYE
KSKPLVNLVD NMVKLGSLYR NDANGRVQPA TLDRLEFNQR MQEQQMLQEE QQQWERLSPN
QAELQAKVRE LYQLDQLLQE ESGTLQSLQR DKEDLERALG GLRARIHDSN ATPMALEAAK
KQQHILEREL SRVHQLLAEN SKKLEQTVAG NARLEQELLL LRQKVQAVRG STTNGMNGDG
SHINGDQTAA VLASELERVQ SLVGDMQRQR HELSSAVRQL TENSTRLYQE IGNKEMNGGG
STNGSLKKRS NSTSWTETDL DANMLRCGSR QQLNDSTLNL STPLYVDTNS STKLSDYNRY
NGSSDAIEMS GVDSDGFLDS NPFALGLEKQ EIKTVRIVKR ESERRNRDRS ERGLSNSIQN
LDQVLEEEQY AQQQREQQLY AQNLEEPMTN GHHSRSKSLP RNYSEPPKQR HSRHLNGGKQ
NGHHYNGGYD YDRNSNYEHQ PPPPPAPQSN GHHHNHQQRE QREHLNPLAN AYFAKQLQQQ
ANPSRDSARV ALRTKTDSLQ SLNKSLTDIS PEPVFQSVAA RQIINEMSAG SASEDTEKVV
EKVPPHHKHR RAVPREKRRH YTAPNNVNQK AMEKVQAEND MNRNNTNWRA RDDLDMEVAL
RPRMNAPDVV RSALGQGEKI SENTIDNLLL APNKIVIPER YIPETTPELS PEEKKRRQEK
VESIKKMLAE APISSNENES LPPSKINAEK KQREHLLQLN QILAQQVMQV SKIVAGNPTS
HN
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