ID A0A0B4LF37_DROME Unreviewed; 1306 AA.
AC A0A0B4LF37;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=No mechanoreceptor potential A, isoform F {ECO:0000313|EMBL:AHN56110.1};
GN Name=nompA {ECO:0000313|EMBL:AHN56110.1,
GN ECO:0000313|FlyBase:FBgn0016047};
GN Synonyms=Dmel\CG13207 {ECO:0000313|EMBL:AHN56110.1}, nomp
GN {ECO:0000313|EMBL:AHN56110.1}, Nomp-A {ECO:0000313|EMBL:AHN56110.1},
GN NOMPA {ECO:0000313|EMBL:AHN56110.1}, NompA
GN {ECO:0000313|EMBL:AHN56110.1}, y {ECO:0000313|EMBL:AHN56110.1};
GN ORFNames=CG13207 {ECO:0000313|EMBL:AHN56110.1,
GN ECO:0000313|FlyBase:FBgn0016047}, Dmel_CG13207
GN {ECO:0000313|EMBL:AHN56110.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AHN56110.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE013599; AHN56110.1; -; Genomic_DNA.
DR RefSeq; NP_001286312.1; NM_001299383.1.
DR DNASU; 45587; -.
DR EnsemblMetazoa; FBtr0339483; FBpp0308565; FBgn0016047.
DR GeneID; 45587; -.
DR KEGG; dme:Dmel_CG13207; -.
DR AGR; FB:FBgn0016047; -.
DR CTD; 45587; -.
DR FlyBase; FBgn0016047; nompA.
DR VEuPathDB; VectorBase:FBgn0016047; -.
DR OrthoDB; 2872850at2759; -.
DR BioGRID-ORCS; 45587; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 45587; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0016047; Expressed in embryonic labial sensory complex (Drosophila) and 7 other cell types or tissues.
DR ExpressionAtlas; A0A0B4LF37; baseline and differential.
DR GO; GO:0031012; C:extracellular matrix; IDA:FlyBase.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IMP:FlyBase.
DR GO; GO:0050954; P:sensory perception of mechanical stimulus; IMP:FlyBase.
DR GO; GO:0007605; P:sensory perception of sound; IMP:FlyBase.
DR CDD; cd01099; PAN_AP_HGF; 4.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR47327:SF13; APPLE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47327; FI18240P1-RELATED; 1.
DR Pfam; PF00024; PAN_1; 4.
DR SMART; SM00473; PAN_AP; 4.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 4.
DR PROSITE; PS50948; PAN; 5.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1306
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002107554"
FT TRANSMEM 1125..1150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..138
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 148..232
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 239..323
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 347..426
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 660..761
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 774..1016
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT REGION 436..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1306 AA; 146116 MW; A4DCBAD56204361E CRC64;
MRPRKGIHVL LTTLVVSLSL SKINGQTTCK NGLGRVLYER LPNQQLQGYD DDVVRDTAPP
FRVLEKCQDL CLRDRSGSNN LVRTCTSFDF QPGSRITSFG GNSEYEESLC YLTSEQAGPE
GIGSLMLVPN SVHFNEICLT SSRPERECPS RRYVFERHPR KKLKLPISDI KEITAANRSD
CEDKCLNEFS FVCRSANFDS TMRSCTLSRF TRRTHPELME DDPNSDYLEN TCLNAERRCD
GLAVFVKEEN KRLGGPFEVD IFNNMTLEEC QTMCLRAEKY FCRSVEFDDQ SKQCILSEED
SISQKDDISI SSSPTHHFYD LVCLDNQRAN DYPDNSVTSH LFSSGRRPDT AFQRYRNSRL
GGEFHSEITG RSLSECLDEC LRQTSFQCRS AVYSDRFRTC RLSRYNQKDG MRIIYDADYD
YYENLMLNVV GGGADGDGGG HGGSSDGKRP GDQSGSNWRQ PNKHDDRYGS GGSSVGGGSH
GGTGSGGSRL PPGEGVDYGR PYDRYPDIAG NEYDRNPYGG DRDRDRYPPD RYGSRYPTGG
DGIGYNRPYD RFPDDYGLER PPPPFYDYDY EERYGDRYGP YDREYDGPPG RRPPSGGPYG
RYDSPFNRPY GGNGLDDRPL PLPGLGLSHP PTPYGGGGAG HVGVGVGVNS GPPRPPITRC
EESDNFKQIA ARHKMRRHFV RRALIVPSLI QCERECIESR DFVCRSFNYR DSAASGYEDR
DRDRDRDSPN CELSDRDSRE LDIHDPGTFD ASNYDFYERS IGRSDGECMD VTQTCNEEGM
EFTIRTPEGF LGRIYTYGFY DRCFFRGNGG TVNVLRLSGP QGYPDCGTQR YGDTLTNIVV
VQFSDNVQTS RDKRYNLTCI FRGPGEAVVS SGYIGAGSGS PIPIEYLPAE NTLSSKVRLS
ILYQGRPTTT IAVGDPLTFR LEAQDGYNHV TDIFATNVVA RDPYSGRSIQ LIDRFGCPVD
PFVFPELDKL RDGDTLEARF NAFKIPESNF LVFEATVRSC REGCQPAYCP GPAGRQEPSF
GRRRRSLNTT EIPEPEALAL EGSSQLEAST LDEVTVVNST TVSATLGQVP LNETQLGEKT
KETEEPEQVR EMIEVFETRE EIEKESYPRK LVAPVETVCM TPAEYHGLIT AIILLMILLF
SITLVAGLGY RRYWKSISKN RLVDRHSPIH SLGHSHSSIR THERFTEIGH MPNLNGGGGG
AAAGTGGGAN QSASNRASNA FRTNMSMFGG SLHKTFATGN LARMCQLPVI NPMRSTNQSS
HQFEDPSEPI YTDPSLFERS RQVADHSVTH PQNEFPTTVR NYRCEV
//
