ID A0A0B4RAR3_9BACL Unreviewed; 1020 AA.
AC A0A0B4RAR3;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=Plano_1101 {ECO:0000313|EMBL:AIY05066.1};
OS Planococcus sp. PAMC 21323.
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Planococcus.
OX NCBI_TaxID=1526927 {ECO:0000313|EMBL:AIY05066.1, ECO:0000313|Proteomes:UP000031496};
RN [1] {ECO:0000313|EMBL:AIY05066.1, ECO:0000313|Proteomes:UP000031496}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PAMC 21323 {ECO:0000313|EMBL:AIY05066.1,
RC ECO:0000313|Proteomes:UP000031496};
RA Jung J.-H., Joe M.-H., Cho Y.-J., Lee S.G., Han S.J., Lim S., Choi J.-i.;
RT "Complete genome sequence of Planococcus sp. PAMC21323 isolated from the
RT Antarctica.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC and theta chains) that associates with a tau subunit. This core
CC dimerizes to form the POLIII' complex. PolIII' associates with the
CC gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC and with the beta chain to form the complete DNA polymerase III
CC complex. {ECO:0000256|ARBA:ARBA00026073}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP009129; AIY05066.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B4RAR3; -.
DR STRING; 1526927.Plano_1101; -.
DR KEGG; pln:Plano_1101; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_0_1_9; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000031496; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:AIY05066.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031496};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AIY05066.1}.
FT DOMAIN 7..122
FT /note="PHP"
FT /evidence="ECO:0000259|Pfam:PF02811"
FT DOMAIN 272..528
FT /note="Bacterial DNA polymerase III alpha subunit NTPase"
FT /evidence="ECO:0000259|Pfam:PF07733"
FT DOMAIN 531..693
FT /note="DNA polymerase III alpha subunit finger"
FT /evidence="ECO:0000259|Pfam:PF17657"
FT DOMAIN 768..852
FT /note="DNA polymerase helix-hairpin-helix motif"
FT /evidence="ECO:0000259|Pfam:PF14579"
FT DOMAIN 944..1019
FT /note="OB"
FT /evidence="ECO:0000259|Pfam:PF01336"
SQ SEQUENCE 1020 AA; 115569 MW; 2131114AA2630F78 CRC64;
MSMVYPHIST SADLLKSTVR LDELFPFLKE QGATSVAIVN SKLYGTLPFW EECRRAGIHG
VVGLSTFIEY DEQYYPVVLY AQSNKGYDNL LKISSALATR DKVAIPEQWL KAYKEGLLCV
IPNKAEWLLT DRSLVVRYIK NLFGQTAFGS IERPGGVVSD YESAFIELCE KLEISIIATH
EIRYMHQQDA FAYEVASSIG QGLKMNDPER QKPEHTNAYV PNPQEFLSWF EDRKEWVQQS
VNLLESCQVN IPLDRQLLPV FPLSEKIDKA AYVAQLCKAG LEERVPGFSG EYQERLNYEL
SIIEKMGFID YFLIVADFMK YAKDQDIMTG PGRGSSASSL VAYSLKITDV DPIEHGLLFE
RFLNPERVTL PDIDIDFADH RRHEVVEYVA QKYGAIRTAQ IITFGTLSAK AVARDTARVF
GFEAEELEAI SKLISNRPGT TLRSALKEST KFNDWIIERE ERKSWFKTAL KLEGLPRHAS
THAAGVILSP TPLVNHVPIE KGNEGIYLTQ WPMQELEAIG LLKMDFLGLR NLTILEQIRS
LVYWDTKKRI NYSKIPLEDE KTYKLLAAGD TTGVFQLESD GMRRALQQIR PTAFGDIVAV
NALYRPGPME FIPLYARRKH GQETVKYVHP ILEPILSETY GVIVYQEQIM QIASKMAGFS
LGEADLLRRA VSKKKREILD EEREHFVQGA KAKKFTEAEA AEVYDLIVRF ADYGFPKSHA
VAYSMISYQL SYMKTHYPVY FYTSLLSNSA GNAEKTKQLL QEIKEKKIPL LPPSIQKSRH
TFSVEDGQIR FGLNAVKGVP GSTIKALLAA REEGPFSSLF NIAERISALH FNRKSFEPLI
KAGALDDFGH DRGVVLASLD SAIKHAELVK PNEEPGLFDD MGASFMKPKY TKASEMPESL
KLEFEKEVLG FYLSKHPIER EKENRQKSYD ALKSLKSKRD REPVKVLGVI EEIKRIRTKK
GDAMAFLTLM DETGPASVTL FPVEYAKYNL LLETHATLEI QGLVENRNHK TAIICKNIET
//
