ID A0A0B4XPE6_9GAMM Unreviewed; 1042 AA.
AC A0A0B4XPE6;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=CzcA family heavy metal RND efflux protein {ECO:0000313|EMBL:AJD48152.1};
GN ORFNames=S7S_08690 {ECO:0000313|EMBL:AJD48152.1};
OS Isoalcanivorax pacificus W11-5.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Alcanivoracaceae; Isoalcanivorax.
OX NCBI_TaxID=391936 {ECO:0000313|EMBL:AJD48152.1, ECO:0000313|Proteomes:UP000006764};
RN [1] {ECO:0000313|EMBL:AJD48152.1, ECO:0000313|Proteomes:UP000006764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W11-5 {ECO:0000313|EMBL:AJD48152.1,
RC ECO:0000313|Proteomes:UP000006764};
RX PubMed=23209202; DOI=10.1128/JB.01845-12;
RA Lai Q., Shao Z.;
RT "Genome sequence of an alkane-degrading bacterium, Alcanivorax pacificus
RT type strain W11-5, isolated from deep sea sediment.";
RL J. Bacteriol. 194:6936-6936(2012).
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR EMBL; CP004387; AJD48152.1; -; Genomic_DNA.
DR RefSeq; WP_041025972.1; NZ_CP004387.1.
DR AlphaFoldDB; A0A0B4XPE6; -.
DR STRING; 391936.S7S_08690; -.
DR KEGG; apac:S7S_08690; -.
DR HOGENOM; CLU_002755_1_2_6; -.
DR OrthoDB; 9758757at2; -.
DR Proteomes; UP000006764; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF19; CATION EFFLUX SYSTEM PROTEIN CUSA; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006764};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 873..890
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 897..917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 923..947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 979..996
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1008..1027
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1042 AA; 113585 MW; EB49B1D953C2A4FB CRC64;
MIAALIRWSL ANRFLVLLAT LFISVWGVWS INNTPVDALP DLSDVQVIIR TSYPGQAPQL
VEQQVTYPIA TTMLAVPGAR AVRGYSFFGD SYVYVLFEDG TDLYWARSRV LEYLNQAQSQ
LPRAARPSLG PDATGVGWIY QYVLIDRTGQ HDLAQLTSLQ DWFLKYELQT LPGVAEVATV
GGMVREYQVV PDPVKLASLG ISHQQVRQAI EEANQETGGA VLTLGEAEFM VRASGYLQSL
ADFRTIPLKL IDGVPVLLGD VAHIRTGPEM RRGIAELNGE GEVVGGVVIL RSGKNARAVL
AAVHERLGVL RNSLPEGVEV VVTYDRSELI DRAVSNLGHK LVEEFIVVAL VCLLFLGHLR
SSLVAIISLP LGILVAFIVM RYQGVNANIM SLGGIAIAIG AMVDAAVVMI ENAHRKIEAW
HRDNPGKSLR GDAHWQVIEQ AAVEVGPALF FSLLIITLSF IPVFTLEAQE GRLFGPLAFT
KTWAMAAAAG LSVTLVPLLM GYWIRGRIPS EEGNPLNRWL TRGYRPVLER VLAWPKITLL
VAGLVFLTTL WPLSHLGGEF LPPLDEGDLL YMPSALPGLS AQKASELLQQ TDRLIKTVPE
VEQVFGKAGR ARTATDPAPL TMFETTIRFK PRDQWRDGMT PGKLVEELDR VVQVPGLANI
WIPPIRNRID MLATGIKSPI GIKVAGDDLA TLDEVGRQIE QIAKQVPGVS SALSERLTGG
RYVDITVRRD LAAQYGLSVA DVQSVVSGLI GGENIGETVE GLARYPISLR YPREWRDTVQ
RLRDLPVVTP GGAQITLGTV TDIAVADGPP MLKSDNGRLS GWIYIDVRNR DLASVVEALR
TAVNEQVVLP AGVSLSFAGQ FEFLERANAR LKVVVPATLL IIFVLLFLTF RRVDEALLIM
TTLPFSVTGG IWLLYLLDYN LSVATGVGFI ALAGVAAEFG VIMLLYLKQA WQARVAQGHR
DEAALVGAIR DGAVLRVRPK AMTVAVIIAG LLPIFWGDGT GGEIMRRIAA PMVGGMITAP
LLSLFVLPAA YRLMRRRDGI EH
//
