ID   A0A0B5CFM2_NEIEG        Unreviewed;       533 AA.
AC   A0A0B5CFM2;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=NELON_02190 {ECO:0000313|EMBL:AJE17807.1};
OS   Neisseria elongata subsp. glycolytica ATCC 29315.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=546263 {ECO:0000313|EMBL:AJE17807.1, ECO:0000313|Proteomes:UP000031392};
RN   [1] {ECO:0000313|Proteomes:UP000031392}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29315 {ECO:0000313|Proteomes:UP000031392};
RA   Veyrier F.J., Taha M.-K.;
RT   "Complete Genome sequence of Neisseria elongata subsp. glycolytica.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AJE17807.1, ECO:0000313|Proteomes:UP000031392}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29315 {ECO:0000313|EMBL:AJE17807.1,
RC   ECO:0000313|Proteomes:UP000031392};
RX   PubMed=26162030;
RA   Veyrier F.J., Biais N., Morales P., Belkacem N., Guilhen C., Ranjeva S.,
RA   Sismeiro O., Pehau-Arnaudet G., Rocha E.P., Werts C., Taha M.K.,
RA   Boneca I.G.;
RT   "Common Cell Shape Evolution of Two Nasopharyngeal Pathogens.";
RL   PLoS Genet. 11:E1005338-E1005338(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; CP007726; AJE17807.1; -; Genomic_DNA.
DR   RefSeq; WP_041961277.1; NZ_CP007726.1.
DR   AlphaFoldDB; A0A0B5CFM2; -.
DR   REBASE; 101338; M.Nel29315ORF2190P.
DR   KEGG; nel:NELON_02190; -.
DR   PATRIC; fig|546263.7.peg.465; -.
DR   HOGENOM; CLU_037306_0_0_4; -.
DR   Proteomes; UP000031392; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR   PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:AJE17807.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031392};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          166..485
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   533 AA;  59981 MW;  A84B5826D18444A0 CRC64;
     MTEQHFTEQT KALIDSLKTI CANYGLGNDG NEFKIISQAF LYKFLNDKYD FEVKQIRKEK
     PDEPIEFVNM DIEGKTAVLK PEHSIKYLSE RQNGADFAKL FDDTLTDIAA QNAELFSVKT
     EGGAKIVLFE RISQYITDEG RRDDFCRALI SKLAGFSFEV IFAQKFDFFA TIFEYLIKDY
     NSNSGGKYAE YYTPHAVARI MADILVPEGV RGKIRSVDVY DPSAGSGTLL MNVAHAIGED
     KCMIYTQDIS QKSSNLLRLN LILNNLVHSL NNVVQGNTIL SPAHKDASGR LKKFDFIVSN
     PPFKLDFSDF RDQLEGEENR ERFFAGIPKI KAKDTDKMEI YQLFIQHILF SLKEKGKAAI
     VLPTGFITAQ SGIDKKIREY LVENKMLAGV VSMPSNIFAT TGTNVSILFI DKANKDKVVL
     IDASGLGEKI KDGKNQKTVL SCAEEQKICN TFTHKQAVED FSVVVSYDEI KAKNYSLSAG
     QYFEVKIDYV DISADEFAQK MAGFSADLDK LFTESAELEK EIKEKLQTLK FNG
//