ID A0A0B5DDD1_9CORY Unreviewed; 1621 AA.
AC A0A0B5DDD1;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Phthiocerol synthesis polyketide synthase type I PpsA {ECO:0000313|EMBL:AJE34248.1};
GN ORFNames=B842_12015 {ECO:0000313|EMBL:AJE34248.1};
OS Corynebacterium humireducens NBRC 106098 = DSM 45392.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1223515 {ECO:0000313|EMBL:AJE34248.1, ECO:0000313|Proteomes:UP000031524};
RN [1] {ECO:0000313|EMBL:AJE34248.1, ECO:0000313|Proteomes:UP000031524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MFC-5 {ECO:0000313|Proteomes:UP000031524};
RA Ruckert C., Albersmeier A., Kalinowski J.;
RT "Complete genome sequence of Corynebacterium humireducens DSM 45392(T),
RT isolated from a wastewater-fed microbial fuel cell.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP005286; AJE34248.1; -; Genomic_DNA.
DR RefSeq; WP_040086940.1; NZ_CP005286.1.
DR STRING; 1223515.B842_12015; -.
DR KEGG; chm:B842_12015; -.
DR HOGENOM; CLU_000022_26_1_11; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000031524; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; NF040607; mycolic_Pks13; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..87
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 112..535
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1150..1224
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 87..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1621 AA; 172613 MW; 439BEBFDF4F5792C CRC64;
MTESQAPATM TVEQLRGWLR DWVVDVTGLS PDEVTDTKPM ENFGLSSRDA VVMSGELENL
LGVQLDATIA YEYPTIQALA QRLIDGEPAS RERSRPRSRH AGVSGAAQTP GTHDIAVVGM
AGRFPGAGDL DAYWSMLVEG RDGTGALPIG RWSEYAAEET MAAKMAEQPL TGGYLDDLAN
FDAEFFGLSP LEAANMDPQQ RIMLEVAWEA LEDAHIPPNT LRGEPVGVFL GSSNNDYGML
ITADPAEAHP YALTGTASSI IPNRISYAFD FRGPSVNVDT ACSSSLVAIH QAVRALRDGD
ADVALAGGVN ILASPFVTTA FGELGVLSPT GHIHAFSDDA DGFVRADGAG VVVLKRVADA
LADGDRILAV IKGSAVNSDG HSNGLTAPNP DAQIDVLARA YADAGVDPAD VDYVEAHGTG
TILGDPIEAT ALGAVLGEGR EMSRPTLLGS VKSNIGHAES AAGAAGLIKV VQSIQHGVIP
PSLHFAGPNR YIDFDAERLE VVEDPREWPE YSGRRIAGVS GFGFGGTNAH LVVSSFDAAD
YAPAEGEEAP APAEAQLPDA EHPNAVLLPV SGLLPSRRRQ AAADLADFLE ERPDTDLVPV
ARSLAGRNHG RSRAVVTADN VADAVKRLRQ VAEGKVSVGI TAADAPSAVG PVFVYSGFGS
QHRLMVKELV AASPLFRARL EELDERVQFE SGWSVLEIVN DDEQTYDTET AQVAITAIQI
ALTDLLAAFG AKPAAVMGMS MGEIAAAYAA GGLSADDAMQ IACHRARLMG EGEKSLPEDQ
LGAMAVVELS TEALEELNAE ETFADIEPAV YAGPGMTTVG GPREQVTALV EKLEEEGKFA
RLLNVKGAGH TSAVEPLLGE LGFETAGITP TPLHTPLISS VDRGVIHQPG ETVHDTDYWL
RMTRQAVYFQ DATEQAFANG HTTLVEIAPN PVAIMGMMNT AFSVGKPDAQ LLFALKRKVG
EVDALRDLLA KLYATGAPVD FSLVYGPGEV IPAPHITWKH QRFWTNARPA SHRAADLPGQ
RVTLPNGVVA FATTADEVPS ALALLERAAE AVQPGAQLVA AEEHAMLPVN GDITTVVTRS
IGGVTLTVHS VSEAGTTTLL AEGFATSLAL GAPRTVPGVQ TPQATDVPDY APLTDAVEVE
EVRWDPASGE SVEDRLRAIV SESMGYDVDD LPRELPLIDL GLDSLMGMRI KNRVENDFQI
PPLQVQALRD ASVADVVRIV EEAVAAKSEG TSLLEPVVSV EDVEEAETEV REAGELPAGD
APQGVGVAPR DAAERMVFGT WAGITGKAPA GVTSTLPEIT EDVAKEIAER LSDRVGREIE
PGQVLEVDTL EPLANIVRDA LETEVEGNIR VLRARPEGST KPSVFMFHPA GGSSVVFLPL
TRRLPEDVPV YGVERLEGTL EERAAAYIDE IREYSDGRPV VLGGWSFGGA LAYEVAHQLK
DTDVEVAYIA LLDTVQPSEP VPDTMEETKA RWKRYSEFAK KTYGLDFPVP YELLETAGEE
AMLGMLEQFL ATTDASEHGL AAGVLEHQRA SFVDNRILDK LDFHRWAEVQ LPVVLFRAER
MHDGAIELEP RYAHIDPDGG WSAIVDDLDI VQLKGDHLAV PDEPAIGVVG AHMAKRINEL
E
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