ID A0A0B5DMP6_9ACTN Unreviewed; 228 AA.
AC A0A0B5DMP6;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Futalosine hydrolase {ECO:0000256|HAMAP-Rule:MF_00991};
DE Short=FL hydrolase {ECO:0000256|HAMAP-Rule:MF_00991};
DE EC=3.2.2.26 {ECO:0000256|HAMAP-Rule:MF_00991};
DE AltName: Full=Futalosine nucleosidase {ECO:0000256|HAMAP-Rule:MF_00991};
DE AltName: Full=Menaquinone biosynthetic enzyme MqnB {ECO:0000256|HAMAP-Rule:MF_00991};
GN Name=mqnB {ECO:0000256|HAMAP-Rule:MF_00991};
GN ORFNames=CP978_15525 {ECO:0000313|EMBL:QEV39776.1}, SNOD_15215
GN {ECO:0000313|EMBL:AJE41232.1};
OS Streptomyces nodosus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=40318 {ECO:0000313|EMBL:AJE41232.1, ECO:0000313|Proteomes:UP000031526};
RN [1] {ECO:0000313|Proteomes:UP000031526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|Proteomes:UP000031526};
RA Sweeney P., Stephens N., Murphy C., Caffrey P.;
RT "Sequence of the Streptomyces nodosus genome.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AJE41232.1, ECO:0000313|Proteomes:UP000031526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|EMBL:AJE41232.1,
RC ECO:0000313|Proteomes:UP000031526};
RX PubMed=26497174;
RA Sweeney P., Murphy C.D., Caffrey P.;
RT "Exploiting the genome sequence of Streptomyces nodosus for enhanced
RT antibiotic production.";
RL Appl. Microbiol. Biotechnol. 100:1285-1295(2016).
RN [3] {ECO:0000313|EMBL:QEV39776.1, ECO:0000313|Proteomes:UP000325763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|EMBL:QEV39776.1,
RC ECO:0000313|Proteomes:UP000325763};
RA Lee N., Cho B.-K.;
RT "Streptomyces genome completion.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine
CC futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of
CC menaquinone (MK, vitamin K2). {ECO:0000256|HAMAP-Rule:MF_00991}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=futalosine + H2O = dehypoxanthine futalosine + hypoxanthine;
CC Xref=Rhea:RHEA:25904, ChEBI:CHEBI:15377, ChEBI:CHEBI:17368,
CC ChEBI:CHEBI:58863, ChEBI:CHEBI:58864; EC=3.2.2.26;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00991};
CC -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC {ECO:0000256|HAMAP-Rule:MF_00991}.
CC -!- SIMILARITY: Belongs to the PNP/UDP phosphorylase family. Futalosine
CC hydrolase subfamily. {ECO:0000256|HAMAP-Rule:MF_00991}.
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DR EMBL; CP009313; AJE41232.1; -; Genomic_DNA.
DR EMBL; CP023747; QEV39776.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B5DMP6; -.
DR STRING; 40318.SNOD_15215; -.
DR KEGG; snq:CP978_15525; -.
DR HOGENOM; CLU_031248_3_0_11; -.
DR OrthoDB; 9788270at2; -.
DR UniPathway; UPA00079; -.
DR Proteomes; UP000031526; Chromosome.
DR Proteomes; UP000325763; Chromosome.
DR GO; GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:UniProtKB-UniRule.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR CDD; cd17766; futalosine_nucleosidase_MqnB; 1.
DR Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR HAMAP; MF_00991; MqnB; 1.
DR InterPro; IPR019963; FL_hydrolase_MqnB.
DR InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR NCBIfam; TIGR03664; fut_nucase; 1.
DR PANTHER; PTHR46832; 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; 1.
DR PANTHER; PTHR46832:SF2; FUTALOSINE HYDROLASE; 1.
DR Pfam; PF01048; PNP_UDP_1; 1.
DR SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000313|EMBL:QEV39776.1};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_00991, ECO:0000313|EMBL:QEV39776.1};
KW Menaquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_00991};
KW Reference proteome {ECO:0000313|Proteomes:UP000031526}.
FT DOMAIN 41..198
FT /note="Nucleoside phosphorylase"
FT /evidence="ECO:0000259|Pfam:PF01048"
SQ SEQUENCE 228 AA; 22545 MW; 591FFC593A3EEFD1 CRC64;
MATAVPAERD AVAGAFCSPA VEIPLPGATL HRVGALDLLA AGVGPALAAA SAAAALTAAA
LGGTPYGLVV CAGIAGGFAP DAPVGSLIVA DEIVAADLGA ETPDGFLPVT ELGFGTVRHR
PPEPLVRDLA TAADAFTGGV LTVSTVTGSA ARAAELRARH PRALAEAMEG FGVAEAAAAH
RTPVVEVRAV SNPVGPRDRA AWRIGDALTA LTEGFGKLAP VLESWNPA
//
