ID A0A0B5DRX5_9ACTN Unreviewed; 339 AA.
AC A0A0B5DRX5;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:AJE43346.1, ECO:0000313|EMBL:QEV41842.1};
DE SubName: Full=Phosphoglycerate dehydrogenase-like enzyme {ECO:0000313|EMBL:MBB4794778.1};
GN ORFNames=BJY54_005390 {ECO:0000313|EMBL:MBB4794778.1}, CP978_27705
GN {ECO:0000313|EMBL:QEV41842.1}, SNOD_27420
GN {ECO:0000313|EMBL:AJE43346.1};
OS Streptomyces nodosus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=40318 {ECO:0000313|EMBL:AJE43346.1, ECO:0000313|Proteomes:UP000031526};
RN [1] {ECO:0000313|Proteomes:UP000031526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|Proteomes:UP000031526};
RA Sweeney P., Stephens N., Murphy C., Caffrey P.;
RT "Sequence of the Streptomyces nodosus genome.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AJE43346.1, ECO:0000313|Proteomes:UP000031526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|EMBL:AJE43346.1,
RC ECO:0000313|Proteomes:UP000031526};
RX PubMed=26497174;
RA Sweeney P., Murphy C.D., Caffrey P.;
RT "Exploiting the genome sequence of Streptomyces nodosus for enhanced
RT antibiotic production.";
RL Appl. Microbiol. Biotechnol. 100:1285-1295(2016).
RN [3] {ECO:0000313|EMBL:QEV41842.1, ECO:0000313|Proteomes:UP000325763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|EMBL:QEV41842.1,
RC ECO:0000313|Proteomes:UP000325763};
RA Lee N., Cho B.-K.;
RT "Streptomyces genome completion.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:MBB4794778.1, ECO:0000313|Proteomes:UP000544950}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40109 {ECO:0000313|EMBL:MBB4794778.1,
RC ECO:0000313|Proteomes:UP000544950};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP009313; AJE43346.1; -; Genomic_DNA.
DR EMBL; JACHMR010000001; MBB4794778.1; -; Genomic_DNA.
DR EMBL; CP023747; QEV41842.1; -; Genomic_DNA.
DR RefSeq; WP_043445264.1; NZ_JACHMR010000001.1.
DR STRING; 40318.SNOD_27420; -.
DR KEGG; snq:CP978_27705; -.
DR HOGENOM; CLU_019796_1_3_11; -.
DR OrthoDB; 4324715at2; -.
DR Proteomes; UP000031526; Chromosome.
DR Proteomes; UP000325763; Chromosome.
DR Proteomes; UP000544950; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd12167; 2-Hacid_dh_8; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000031526}.
FT DOMAIN 135..297
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 339 AA; 36314 MW; 3BA135F6E6F81CEE CRC64;
MQTTPSALVV MSRESFEAHF DAARLARLAD LVTLGDPVWT DDLDTPAVRA RLADVEVMLT
SWGAPRLTPE RLDAAPALRM VLHCAGSVRG LVGDDVWRRG IRITSAADTN AVPVAEYTLA
AIIFAGKKVP FIAADERLAY EGWGRVTGYG DLSNFAQTVG IVGFSRIGRK VVELLKVLDD
TTCLVADPYA DPAEVAAAGA TLVELRELLP RVDVLSLHAP ELQETRHLIG AEQLRLLPDH
ATVINTARGS LVDSDALAAE CASGRLFAIL DVTDPEPLPA SSPLRRLAQV MVTPHVAGSL
GSEIGRLTDH TIDELARWLG QQPLRGEVTA ESWALGLSA
//
