ID A0A0B5DXJ8_9RHOB Unreviewed; 1051 AA.
AC A0A0B5DXJ8;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=P73_1115 {ECO:0000313|EMBL:AJE45830.1};
OS Celeribacter indicus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Celeribacter.
OX NCBI_TaxID=1208324 {ECO:0000313|EMBL:AJE45830.1, ECO:0000313|Proteomes:UP000031521};
RN [1] {ECO:0000313|EMBL:AJE45830.1, ECO:0000313|Proteomes:UP000031521}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P73 {ECO:0000313|EMBL:AJE45830.1};
RX PubMed=25256706; DOI=10.1099/ijs.0.069039-0;
RA Lai Q., Cao J., Yuan J., Li F., Shao Z.;
RT "Celeribacter indicus sp. nov., a polycyclic aromatic hydrocarbon-degrading
RT bacterium from deep-sea sediment and reclassification of Huaishuia
RT halophila as Celeribacter halophilus comb. nov.";
RL Int. J. Syst. Evol. Microbiol. 64:4160-4167(2014).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
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DR EMBL; CP004393; AJE45830.1; -; Genomic_DNA.
DR RefSeq; WP_043868827.1; NZ_FNNW01000005.1.
DR AlphaFoldDB; A0A0B5DXJ8; -.
DR STRING; 1208324.P73_1115; -.
DR KEGG; cid:P73_1115; -.
DR HOGENOM; CLU_002755_0_1_5; -.
DR OrthoDB; 9807350at2; -.
DR Proteomes; UP000031521; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF10; EFFLUX PUMP MEMBRANE TRANSPORTER; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000031521};
KW Transmembrane {ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 341..360
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 435..459
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 471..498
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 543..564
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 870..889
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 896..916
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 922..945
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 966..987
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1007..1028
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT DOMAIN 381..496
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1051 AA; 111684 MW; 9ED5ED78E89D5C47 CRC64;
MARFFIDNPV LAWVIAIFIS IAGLLSLPML PVAQYPDVAP PQVTISTRFA GSSPEDLYQQ
VTQPIEEELN GIPGMLYYES TSEATGAVTI TVTFASGTNI AQAVVDTQNR LRRVESSLPP
QVQQEGLLVE EASSAYLLYV SLSATEGSDL DLVALADFAT RNVLNEIRRV PGVGKAQLFA
AERAMRVWID PAKLVGLDLS VTDITAAITE QNAQVAAGSV GVDPAPAGQQ TQATLLVTGQ
LRSPEEFGQI VLRARDDGAL VRLSDVARIE VDAELYSFQS YLNGQEAAQI GIQLSPTGNA
LDTAQGVKDL LEELAPTFPA GVEYAIPYDT TPFVAASIEK VVHTLMEAVA LVFVVMLIFL
QSFRYTVIPM LVVPIALAGT MAVMLGAGFS INVLTMFAMI LAIGILVDDA IVVVENVERI
MSEEGLSPKE AAKKAMDQIS GAIVGITLAL MAVFVPLAFF PGSVGIIYQQ FSLTMVVSIF
FSAFLALSLT PALCATFLKP IPKGHGHAKR GPAGWFNRNF DRASRGYAGL VGRLVRRSGR
MMVIYAALVA GLAWFYVQIP AAFLPQEDQG YLIASMQSPP EATSYRMREV TKTAEDFALS
TEGVKDIITI QGFSFSGQGP NSAVSFLTLE DWEERSTPDL SAGALAGKMS GMLFSIRDSF
AFAISPPPIQ GLGTGSGFSF RLQDRGNHGN AALQEVAGQI MAGAAASPVL GQVYVEGLEP
GPQLNLRVDR EKANAFGVTF GEINRTISVA LGSGYVNDFP SNGKMQSVIV QAEPYARANI
EEVMKLNVRN VQGGMVPLSS FASADWGFGP TQIVGYNGYP SIRINGEAAP GYSSGEALAE
MERLVADLPP GFTHQWTGQS LQEIESGSQA PILIGLSVLF VFLCLAGLYG SWSIPFAVML
IVPMGAIGTV AAVTLTGLAN DVFFTVGLIT IVGLSAKNAI LIVEVAKDLI MEGRGLLDAT
IEACRLRFRP ILMTSLAFTM GVVPMAIATG PSAASQNAIG TNVVGGMISA TVLGVLFAPV
FFVFVMKLTS THKRLRRPAA GEETSSVSQP T
//
