ID A0A0B5EP36_STRA4 Unreviewed; 5828 AA.
AC A0A0B5EP36;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Amino acid adenylation domain protein {ECO:0000313|EMBL:AJE80571.1};
GN ORFNames=SLNWT_0195 {ECO:0000313|EMBL:AJE80571.1};
OS Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 /
OS NBRC 107858).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1081613 {ECO:0000313|EMBL:AJE80571.1, ECO:0000313|Proteomes:UP000031523};
RN [1] {ECO:0000313|EMBL:AJE80571.1, ECO:0000313|Proteomes:UP000031523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858
RC {ECO:0000313|Proteomes:UP000031523};
RA Lu C.;
RT "Enhanced salinomycin production by adjusting the supply of polyketide
RT extender units in Streptomyce albus DSM 41398.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP010519; AJE80571.1; -; Genomic_DNA.
DR KEGG; sals:SLNWT_0195; -.
DR Proteomes; UP000031523; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd19540; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000031523}.
FT DOMAIN 997..1072
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2048..2123
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3111..3186
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4168..4242
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5242..5316
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 65..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1067..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2029..2051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2341..2362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4818..4882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5318..5338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5780..5828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4831..4859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5790..5810
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5828 AA; 618376 MW; B52C742B671943D5 CRC64;
MSPHRDRLPL TSAQQGLWTA QRLDPAGCAH LAAEYVELTG PLRPELLAEA IRHTLAETDA
LTVRFTTGDD GTGDTTDNDN TTDNDGTSGK DSTAGSATGD GTGDDDAEES GAEAVRQLVG
AHTPQAPETL DLRGEADPEA AALAWMNGDR SRPVDLESGR LYRHALLRTG EERWLWYHRC
HHILLDGYGF ARVAERVAAL YRALDAGEPL PEAGILPLRE AVAADREYAR STQRSRDAAF
WQQHLADRPR PVSLSRHHGD TPPASTFLRV RRGLEPAALR ELAATAGLAK ATWPEAVLAA
WALYLTGLGG AAEAVVGLPV TGRSGSGLRV PTTAVNVVPL RLAVGTGDTL AGLLARVKDA
LRAQRRHQRY RGEQIRRDLR QFGQGRTLVG PHVNIKPFAP ELSFGRCTAT THYLAAGAVD
DLTVTATQDA NGALQLFFDA HPGRYEEAEL AAHADRFTAL LARLPAHRPD TPVARLPLTG
PAEHRELTRT WATGPGTPDR APLLIEAFGA QVRATPEAPA LRSGADTLTY AALDARAREL
AGVLAARGAR RGTLVAVGVD RAPALLVTLL AVLRTGAGYV PLDPAYPAGR LRRMLTDSAP
ALLVTDRPGT GDATVPEVTV DHHGTALGTA PGDDAGAGVP VGEGDTAYVI YTSGSTGRPK
GVVVSHGALA NLLAALPRGP RPAEGERLLA VTTVSFDIAA LELFLPLICG ATVVLADAET
VRDPFALTAL IRAERPAVVQ ATPSLWRLLA EADPGALAGV RLLSGGEALA PDLAERLSGL
GASLTNLYGP TETTIWSTAA ALEPGTLPHA GSPLRRTRAY VLGHRLNALP AGTTGELYLA
GDGVADGYLN RPALTGERFT ADPFGPPGAR MYRTGDLARW TTGGRLEIVG RADHQVKIRG
HRVEPGEVAA ALAAHPAVRE AAVTARPPAG GGEAVLAAFY VGAAEEAALR AHLAQRLPAH
LIPAHFRALD RLPRTPNGKT DVAALPEITA PTAGRRAPAT GREELLCRLF AEVLGLDEVG
ADDDFFALGG HSLSAARLMT ALRASAGVEL PVRTLFDHPT PALLAAPSEH AAGARPPLRP
EPRPERLPLS PGQRRLWFLH QADPAGGSYH IPLAVRLTGE LDPAALRAAL RDVLARHEVL
RTVFPPTGDE PRQEIREAAA LTVPLELRHL DSPAEEEAAL RAAAARPLEI EDRLPLRAHL
FTTRDTSGSV GQVLLLVVHH IAGDEWSLAP LLRDLAAAYT ARAGGEAPGL PPLPVQYADH
TLWQRRTAPA TEDAQLAYWR RALDQAPEQI TLPWARPRPR HTGGGAATHG FTLDGALHTR
VTELARTTGT TVFMVLHAAL AATLTRLGAG EDIVVGAPVA GREDEALREA AGFFINTLVL
RTDTSGTPTF HELLARVRES DLGALSHQDV PFERIVEALN PPRSTGLTPL FQILFAVREE
FDERPLLPGQ SGRPWLVHTG EAKFDLQLTV SEQGAGREAG ALLEYRTALW DAADAARFAT
AYVRLLDELT ADPHRPPADV DLLTPAEHAR LAADAAATAR ALPGTSPVHL IAAQAARTPD
RIALHSGGEQ LTYRRLDEQA ARLATVLAAH GARPGTLVGV SLPRGPRLLP ALLAVLRTGA
AYLPLDPDFP AARLATLLDD ACPALLVTDR PEAAPPGVTA LVDPADPGTR SRIEAAEPLP
LPPSRHGGHP AYVIHTSGST GTPKGVIIPE RALTNFLLAT AEQLAFTGEE RLLAVTTVGF
DIAALELFLP LTRGATVILA DREEVRDPRL LAALLARTGA TVMQATPSLW RALAEQAPEA
VRPLRVLAGG EALAPDLAAR LAALGTGLTN LYGPTETTIW STAATLDTAE DLAAPHVGSP
LWNTRTHVLD RRLRPVPDGL TGELYLAGDG LAQGYLNRGA LTAERFTADP YGPPSTRMYR
TGDLARRRAD GRLEIVGRAD HQVKIRGHRV EPGEVAAVLR RDPRVRDAAV LAHRESGEST
PRLIAYLVGP RDEREAQEVR REAATRLPAY LVPSLCLVLD ALPQTPNGKL DRAALPAPAP
AAAGSSRPAS GPREQALAAL FTDILGLDDV GAEDDFFALG GHSLLAARLV ARARPLLGED
LTVRHLFEAP TVAALAARGR PAAEDGPAAP ALVRRERPAR LPLSPAQARL WFLARLGGTG
TAYHLPFVLT LTGTVDQDAL TAALADVVRR HAVLRTVFPD DGDGPRQQIL DRAPECTRHT
VRDAPARERL LAELAAAPFD VTTQPPLRLS ILTGEKDERG RERLTVLLLV HHIAGDEWST
APLLSDLSTA YAARREHRAP DWPELPVDYA DYALWQRELR HTGEEQLDFW RARLAGAPAV
LDLPTDRPRP AQPTGRGGYV PFTVPAPTAD ALRKLSRTTA TTPFMVLQAA LTALLSALGA
GEDIPLGVPS AGREHPDTED LVGFFVNTLV LRTDLSGDPG FGELLERVRR TTLDAFDHAG
VPFERVVEAL NPERRAHNPL FQVMLTYQVR GPLPFSAPGL DADFGLRETD TAKLDLVVGF
TDHTGTGRLD GAVNYSADLF DEESARLLTE RLLRLLAAAV TAPDTRLSRL PLLSDAEQHT
LLRDFNPTAH HDGHPPVVDR FTAAAEAAAS RTALTHRGSH LSYADLDRRS TRLARHLIGR
GIGPEDRVAL VLPRSPALIE AVLAVAKTGA AYVPVDPRYP AARIRHTLAD ARPALLLTTT
GTDTGESTGA PVVDLDDPEL RALLDRTPDH RITGGERRAP LHPDHAAYLI YTSGSTGTPK
GVVVTHRNLA RLFDATRDPF AFGPEDVWTL FHSYAFDFSV WEMWGALLTG GRLVLVDHET
TRSPEDFLRL LHEERVTVLN QTPTAFTALT ESLARGGGVP GSLRWIVFGG EALEPGRTLP
WLQGPRPPRL LNMYGITETT VHVTGYELTP ARAADAAHRG LSPVGRALED LRLYVLDAAL
RPVPAGVAGE LYVAGPGLAR GYRGRHALTA ERFTADPFGP PGTRMYRSGD LARWSGQGEL
VYLGRADTQV SLRGFRIETG EIEAVLGRHP DAGTAAVVLR TDLPTGDGLV AYTTGTATAD
RLRETCAAVL PEHMVPAAFV TLDALPLTAN GKLDRAALPA PTAPAAAQGR APRTPLEEQL
AALYADILGT EAVGADEDFF AAGGHSLLLT RLAGRIRAEL GTHLAVRTLF EARTVAALAA
HLTGTTDATA APAPLTRAAR PAVLPLSPAQ ARLWFLHRLG GTAHAYTVPL LLHPAAPLDE
TALTAALADL AERHEILRTA YPAGPDGVPV QHILDAAEVP APRTLATTDP AATARELAAE
PFELTTRPPL RSYLLTDREG GRHLLLLLHH IAVDEFSTGP LLADLARLYT ARRAGTPLPP
GPRHQYADYT LWQRQALTHR AEPLLAHWRT VLAGAPAEIP LPLDRPRPGE VDHHGDSVEF
TLPAAVHRAA ADLAEEAGAS LFMVLHAALA ALLTAHGAGT DLPLGTVLSN RADPALAEVP
GLIANTLVLR TDTSGDPSFA ELLQRVKSVD LDAFDHGELP FEQLVDALDP ERSLSRHPLF
QVALIHQRAP GEPTDFGGTA VAAELVELRG AKFDLTLAVV EDPDSLAQHG LKAAFNYRTA
LFDPETVQGL ARRLTALLHW CTAHPEAPLS AAPVLDEAEH RAVLAAATGP TRALPPATLA
DLVRAQARRT PAHQALTDGE RSWSYAEFDA GADRLAAALT ALGTRRGHIV AVALPRSPEL
VLALHAVQRA GAAYLPVDPD LPAARVRTLL TRSGARAVVT TTALAAHTNP TALPQLDPTR
ADFTDAGAPD PTVTDPTATA PLPGDPAYVL FTSGSTGTPK GVVITHTAIV NRLLWAQDTY
RLTDTDRVLL KTPASFDVSV WELFWPLLAG ATLVTAGPED HRDPAALARR LREQRITTVH
FVPSMLAAFT AVAEQADCAH LTRVLASGET LPPAAVAQTA RLAPAAVLHN LYGPTEAAVD
VTAHATTAAD ATRAAVPIGR PVANTRAHVL DAALRPVPPG VGGELYLAGP QLALGYLNQP
ALSAERFTAD PFGPPGSRLY RTGDLARLRH DGALEHLGRA DDQIKLRGQR IEPGEIQAVL
DAHPALAHSA VTVFTDPATG AAHLAAYLVP ATGESVPDLD PYLSARLPAH LVPASLTVLD
ALPVTANGKL DRAALPAPRL SSQEAFSAPE SDEERLLAAL FARLLHVDTI GLDDSFFALG
GDSILSIQLV AAAREAGLAF TPQDVFRRRT VRALLAAARR EPRPAEAPAA SAEGPWPATP
LQEGLLFLSH YDHSAPGALD VYHVQGVLPL TGTVDHERLT AALRRLLERH APLRTAFTRT
DEGWIQRTHP VRAHVEILDL TRRTPRETER RARRRIEDER LARFDLTAPP LLRALLIRRT
ADTGDLVLTG HHLVLDGWSM PLLVRELLHG HGGDLPAPQG PDYGTYLGWL HAQDTGAARD
AWRAALDGLE APTLLAGEAP GATEIPEECL RTADTGLTAA LTAFARSREL TLSALLQSAW
ALVLQAATGG RDLVFGTVVS GRPAEVPAVG EMIGLFVNTV PVRVRIRPEE PLQDLVRRVG
EEFTTLLPHH HLGLADIQRA SGHSRLFDTL TALENYPADG LDALGRAAGL DIGEVSGWDA
THYPLTLVAV PGPQLTLRVK YQPSCFTPAQ AGAFADRVLH VLHLLTRAPG TPVAALNMLL
ASERSALAAH PAPAAPAPAT WAQLVARQVA ERPEAPAVEG PDQRLSYAQL DARARALAAR
LRAAGLCPGD LAALALPRSV DLVVAQLAVQ QAGAAHLPVD PDYPAERVRY MLDDAAPALV
LSCRALADRF PEALLVDTDT DTDTDTGTGT DTDTDTDTGT GTDTGTGTDT GTGTDADIDG
TGTGTEPDGN EDGERAALSG PVPVTPAHPA YLIYTSGSTG RPKGVLTTHA GLAALATAQA
RRLGLEPASR VLQLASPSFD ASVMETMMAL ATGATLVLPE PGPLAGELLG EVLRTRRISH
ALIPPTALTG LEPEDLDGFT TLVVGGEACS TALAARWAPG RRMINAYGPT EATACVTMSA
PLSGKTPPPI GTPLPGVRLY VLDGMLRPVP PGTPGELYAA GEGLARGYLD RHALTAERFT
ADPFGGPGSR MYRTGDIVVR DGDGVLHYRR RADDQVKIRG FRVEPGEITA LLEARPEIRS
AAVTVRQEPG RGPRRLVGYL VPEQGTGPDT RALRAELART LPDHMVPTAF VTLDALPVTA
NGKLDQAALP APDFRAAIGD SACQGPVEQA LAAVFSEVLS LPGVGAQDSF FALGGDSILS
LQLVAKARAA GLALSPREIF EQPTVRRLAA LLADRGTTAP AAGPAAPAAS AGRTDAGHGS
APLTPIMHWL AERGGPTGRF SQSMLLTLPE DIGEEALARV LDAVVAHHQL LRARVDWAAG
TLTVPAPGTG GRHHLPGGGE TASVPGEEGL AREVDVLAAG LDPERGRMLA TRRYRTADGT
GDRLLLVVHH LVVDGVSWRI LLQDLAEAWA AVRTGAPVRL APVPTSFTAW ARSLPALAEE
RRAELPRWQD ILTTGTGLPR LRPAPAYGTV GGARHHTLVL DSAPTTALLT RAVRHFDASI
QHVLLAALAL AVRDWDRPAP EAAAGEGARF LVDVEGHGRE QQIGEGADLS RTVGWFTSLY
PVRLEAAPGE DFAAAVARVR ADLLALPDSG IGYGLLRHLL PAEGNPLAGQ GAPALAFNYL
GRFSAPGGRA PWTAAAEAGV LGGSLDEDLP MAHAVEINAV TRDTPQGPQL HTRLTWAPGA
LDEEAAADLA RHWTEALHTA ARAAGTPGTE PPAEPAPAPP AAPTEKAAPL SPLPPEQTAQ
LAARWRNR
//
