ID A0A0B5ER70_STRA4 Unreviewed; 1613 AA.
AC A0A0B5ER70;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Polyketide synthase type I {ECO:0000313|EMBL:AJE81266.1};
GN ORFNames=SLNWT_0890 {ECO:0000313|EMBL:AJE81266.1};
OS Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 /
OS NBRC 107858).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1081613 {ECO:0000313|EMBL:AJE81266.1, ECO:0000313|Proteomes:UP000031523};
RN [1] {ECO:0000313|EMBL:AJE81266.1, ECO:0000313|Proteomes:UP000031523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858
RC {ECO:0000313|Proteomes:UP000031523};
RA Lu C.;
RT "Enhanced salinomycin production by adjusting the supply of polyketide
RT extender units in Streptomyce albus DSM 41398.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP010519; AJE81266.1; -; Genomic_DNA.
DR KEGG; sals:SLNWT_0890; -.
DR Proteomes; UP000031523; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000031523};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 39..465
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1458..1533
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1578..1598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 10..40
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1613 AA; 167519 MW; E2C8C3925496BCA3 CRC64;
MGLDDMVASN DKLLEALRTS LKETERLREQ NRRLAEASRE PLAIVAMGCR FPGGVRSPQD
LWELLAEGRD ALSPFPADRG WDLDALFDPD PDRAGSSYVR EGGFLDGAAD FDAEFFGISP
REALAMDPQQ RLLLETCWET VEAAGIDPAS LRGSRTGVFV GSNGADYGTV LVGGPEETDG
YLATGNATSV LSGRVSYALG LEGPALTVDT ACSSSLVALH LAAQALRQEE CALALVGGVT
VMASPTTFTE FSRQRGLAAD GRCKAFAAAA DGTGWGEGAG VLLLERLPDA RRNGHQVLAV
LRGSAVNQDG ASNGLTAPNG PSQQRVLRAA LAQARLTPEQ VDAVEAHGTG TTLGDPIEAG
ALLGTYGQQR PEGRPLWLGS VKSNLGHTQA AAGIAGVLKM VLALRHDELP RTLHVDTPTP
QVDWSSGAVR LLTEPRPWPR SAEPRRAGVS SFGMSGTNAH VLLEEAPAEE HESATAPESG
GPLPWILSAR SESALRDRAR DLAALLAARP DARLADIGLS LAVTRTRFPH RAIVVAAEQP
QFQQALTALA EGRPAPSAAE GHAPAARKPV FVFPGQGAQW PGMARELLDT SPVFAERLGQ
CAKALGAYVD WSLPEVVRGT EGAPGLDRVD VVQPALWAVM VSLAALWESY GVRPAAVVGH
SQGEIAAACV AGALSLDDGA RVVALRSRAL VALAGRGGMV SVAADRETAE ALAAPWAGRI
SVAALNGPSS TVLSGDAEAL DELVARAGTG TVRVRRVDVD YASHSAQVEE IQAELAEVLA
PVTPVQARVP FLSSVTAEWL RGEELDGGYW YRNLRGTVRL DEVIRLLGER GGHQFIEVGP
HPVLLPSLPE GGVGTLRRTD GGLDRFLRSL AEAHARGVEA DWSAAFPGAR TTALPTYPFQ
RTRYWPRPGA PGEQQADPAE RAFWAAVDRA DLPALAEEIG AADPARTALE GALPALRHWH
RTRRTRAELA SWAYRVTWSP LAAPPTGTRL SGRWLLLSDA SPGTAGTTDV EGALTAAGAD
TLVLRTGEPT RESLAALLTE AAAGGPVAGV VACPASATEL LALVQALDEV GVSGRLWCLT
RGAVSVSAAS GEVPDPVLAQ VWGFGRVVAL ERPLAWGGLV DLPPEGADAG LLAAVLSGAT
GEDQVALRGG RLLGRRLVRA GTAVTPPAES AAPGAGWRVS SGPVLVTGGT GALGAGVARW
LAGRGAEHLV LAGRRGASAP GAEELVRELG ALGVRVDVVA CDVSDRGSVA ALLAEFVFSA
VFHVAGVVDD GVVGSLSAER FAGVWGPKAG GAELLDELTR GMDLSAFVVF SSFAGAVGGA
GQGNYAAANA QVDALVERRR AEGLPGLSLG WGSWAGGGLA TGSEAVTERL KRGGMRPMDP
ALALTALGAA LDREETHLVV AGVDWERFAD SFLTGRPSPL LGELPEVQAL MAARAAEEDQ
GSALAHRLRD LAPADRESAL LDLVRAQAAA VLGHSTPASV AGTKAFRDAG FDSLTAVELR
NRLGAATGLS LSATLVFDHP TPAALAAHLA AELGTGAESG FEEAFDQVER QLRGLGAGSA
EHTRIMLRMQ ALVAAWRDGP GEESAAEEPA AEGFDTADDD ELFGLIGEKF GIS
//