UniProt: A0A0B5ER70

Database: UniProt
Entry: A0A0B5ER70_STRA4

LinkDB:  A0A0B5ER70_STRA4 
Original site:  A0A0B5ER70_STRA4

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Ontology (4)   
   GO (4)   
Gene (1)   
   KEGG GENES (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (35)   
   InterPro (18)   
   Pfam (8)   
   PROSITE (4)   
   SMART (5)   
All databases (41)   

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ID   A0A0B5ER70_STRA4        Unreviewed;      1613 AA.
AC   A0A0B5ER70;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Polyketide synthase type I {ECO:0000313|EMBL:AJE81266.1};
GN   ORFNames=SLNWT_0890 {ECO:0000313|EMBL:AJE81266.1};
OS   Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 /
OS   NBRC 107858).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1081613 {ECO:0000313|EMBL:AJE81266.1, ECO:0000313|Proteomes:UP000031523};
RN   [1] {ECO:0000313|EMBL:AJE81266.1, ECO:0000313|Proteomes:UP000031523}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858
RC   {ECO:0000313|Proteomes:UP000031523};
RA   Lu C.;
RT   "Enhanced salinomycin production by adjusting the supply of polyketide
RT   extender units in Streptomyce albus DSM 41398.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; CP010519; AJE81266.1; -; Genomic_DNA.
DR   KEGG; sals:SLNWT_0890; -.
DR   Proteomes; UP000031523; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd08952; KR_1_SDR_x; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 6.10.140.1830; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR041618; PKS_DE.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF18369; PKS_DE; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031523};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          39..465
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1458..1533
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1578..1598
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          10..40
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1613 AA;  167519 MW;  E2C8C3925496BCA3 CRC64;
     MGLDDMVASN DKLLEALRTS LKETERLREQ NRRLAEASRE PLAIVAMGCR FPGGVRSPQD
     LWELLAEGRD ALSPFPADRG WDLDALFDPD PDRAGSSYVR EGGFLDGAAD FDAEFFGISP
     REALAMDPQQ RLLLETCWET VEAAGIDPAS LRGSRTGVFV GSNGADYGTV LVGGPEETDG
     YLATGNATSV LSGRVSYALG LEGPALTVDT ACSSSLVALH LAAQALRQEE CALALVGGVT
     VMASPTTFTE FSRQRGLAAD GRCKAFAAAA DGTGWGEGAG VLLLERLPDA RRNGHQVLAV
     LRGSAVNQDG ASNGLTAPNG PSQQRVLRAA LAQARLTPEQ VDAVEAHGTG TTLGDPIEAG
     ALLGTYGQQR PEGRPLWLGS VKSNLGHTQA AAGIAGVLKM VLALRHDELP RTLHVDTPTP
     QVDWSSGAVR LLTEPRPWPR SAEPRRAGVS SFGMSGTNAH VLLEEAPAEE HESATAPESG
     GPLPWILSAR SESALRDRAR DLAALLAARP DARLADIGLS LAVTRTRFPH RAIVVAAEQP
     QFQQALTALA EGRPAPSAAE GHAPAARKPV FVFPGQGAQW PGMARELLDT SPVFAERLGQ
     CAKALGAYVD WSLPEVVRGT EGAPGLDRVD VVQPALWAVM VSLAALWESY GVRPAAVVGH
     SQGEIAAACV AGALSLDDGA RVVALRSRAL VALAGRGGMV SVAADRETAE ALAAPWAGRI
     SVAALNGPSS TVLSGDAEAL DELVARAGTG TVRVRRVDVD YASHSAQVEE IQAELAEVLA
     PVTPVQARVP FLSSVTAEWL RGEELDGGYW YRNLRGTVRL DEVIRLLGER GGHQFIEVGP
     HPVLLPSLPE GGVGTLRRTD GGLDRFLRSL AEAHARGVEA DWSAAFPGAR TTALPTYPFQ
     RTRYWPRPGA PGEQQADPAE RAFWAAVDRA DLPALAEEIG AADPARTALE GALPALRHWH
     RTRRTRAELA SWAYRVTWSP LAAPPTGTRL SGRWLLLSDA SPGTAGTTDV EGALTAAGAD
     TLVLRTGEPT RESLAALLTE AAAGGPVAGV VACPASATEL LALVQALDEV GVSGRLWCLT
     RGAVSVSAAS GEVPDPVLAQ VWGFGRVVAL ERPLAWGGLV DLPPEGADAG LLAAVLSGAT
     GEDQVALRGG RLLGRRLVRA GTAVTPPAES AAPGAGWRVS SGPVLVTGGT GALGAGVARW
     LAGRGAEHLV LAGRRGASAP GAEELVRELG ALGVRVDVVA CDVSDRGSVA ALLAEFVFSA
     VFHVAGVVDD GVVGSLSAER FAGVWGPKAG GAELLDELTR GMDLSAFVVF SSFAGAVGGA
     GQGNYAAANA QVDALVERRR AEGLPGLSLG WGSWAGGGLA TGSEAVTERL KRGGMRPMDP
     ALALTALGAA LDREETHLVV AGVDWERFAD SFLTGRPSPL LGELPEVQAL MAARAAEEDQ
     GSALAHRLRD LAPADRESAL LDLVRAQAAA VLGHSTPASV AGTKAFRDAG FDSLTAVELR
     NRLGAATGLS LSATLVFDHP TPAALAAHLA AELGTGAESG FEEAFDQVER QLRGLGAGSA
     EHTRIMLRMQ ALVAAWRDGP GEESAAEEPA AEGFDTADDD ELFGLIGEKF GIS
//

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