ID A0A0B5ESM2_STRA4 Unreviewed; 750 AA.
AC A0A0B5ESM2;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
GN ORFNames=SLNWT_0756 {ECO:0000313|EMBL:AJE81132.1};
OS Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 /
OS NBRC 107858).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1081613 {ECO:0000313|EMBL:AJE81132.1, ECO:0000313|Proteomes:UP000031523};
RN [1] {ECO:0000313|EMBL:AJE81132.1, ECO:0000313|Proteomes:UP000031523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858
RC {ECO:0000313|Proteomes:UP000031523};
RA Lu C.;
RT "Enhanced salinomycin production by adjusting the supply of polyketide
RT extender units in Streptomyce albus DSM 41398.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP010519; AJE81132.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0B5ESM2; -.
DR KEGG; sals:SLNWT_0756; -.
DR Proteomes; UP000031523; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031523};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 537..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..381
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 416..718
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 726..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 750 AA; 78710 MW; 0C16F89740B3C267 CRC64;
MGNTHARVRG IAARAGGWSA RHRWAAVGIW VLFVVLSLGI GTAVGSVEVK DSDQLSGETS
RAAQIVEEAG IEEPASENVL LQSKDKGPKA TDPEFRSAVA AVIKAVRGTG EAVDVTSPYT
AKTISADGRS ALVQFDMRGE ADTAGDRVEP VLDAVAGVQE KHQGLLIEEI GGASMNKTFD
DAFGDDFQQA EISAVPVALG ILLIAFGALV AALLPVALAV TAIMATMGLM AVVSHVQPMS
ETASSVMLLV GMAVGVDYCL FYLRREREER AAGRDAATAL RIAAATSGRA VMVSGVTVCV
AMAGMLFTGL AEFEAMGLAS LMVVAVAMVG SVTVLPALLS LLGERVEKGR IPFLGRRGRR
TGGGESRLWR GVLRVVLAKP AVSLGVATCA LLAVAAPALG MKTQQLTLDQ EFGKDLPIVA
TYDRLNKAFP GGSDPAEVVV TAEDITSPAV RGALEDFRSQ VVKAGASHGP VDVKVHEKQN
IAFVYVPLIG GSDMDKAEHS LQVIRDEVRP ATLGKVDGLE APVTGQVAGS HDFNEQLVGS
VAPVFVFVVV FAFGLMLLCF RSLTIALTSI VLNLLSVGAA YGILVAVFQH GWGASLVGAE
GVGAIVTWLP LFLFVILFGL SMDYHVFVVS RIREAKVRGR STKDAITHGV VTTAGVVTSA
AVIMVAVFAI FGTLSMQSMK QMGVGLAAAV LIDATVIRGV LLPSVMALLG ERNWYLPKWM
HRLPDLTHDE PEPPAAPEPP RPAQDHRVGV
//
