ID   A0A0B5ETS3_STRA4        Unreviewed;      4493 AA.
AC   A0A0B5ETS3;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:AJE81512.1};
GN   ORFNames=SLNWT_1136 {ECO:0000313|EMBL:AJE81512.1};
OS   Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 /
OS   NBRC 107858).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1081613 {ECO:0000313|EMBL:AJE81512.1, ECO:0000313|Proteomes:UP000031523};
RN   [1] {ECO:0000313|EMBL:AJE81512.1, ECO:0000313|Proteomes:UP000031523}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858
RC   {ECO:0000313|Proteomes:UP000031523};
RA   Lu C.;
RT   "Enhanced salinomycin production by adjusting the supply of polyketide
RT   extender units in Streptomyce albus DSM 41398.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; CP010519; AJE81512.1; -; Genomic_DNA.
DR   KEGG; sals:SLNWT_1136; -.
DR   Proteomes; UP000031523; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR   CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR   CDD; cd12117; A_NRPS_Srf_like; 1.
DR   CDD; cd02440; AdoMet_MTases; 2.
DR   CDD; cd19540; LCL_NRPS-like; 2.
DR   Gene3D; 3.30.300.30; -; 5.
DR   Gene3D; 3.40.50.980; -; 4.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR   NCBIfam; TIGR01720; NRPS-para261; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF13193; AMP-binding_C; 2.
DR   Pfam; PF00668; Condensation; 4.
DR   Pfam; PF08242; Methyltransf_12; 2.
DR   Pfam; PF00550; PP-binding; 3.
DR   SMART; SM00823; PKS_PP; 3.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR   SUPFAM; SSF47336; ACP-like; 3.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR   PROSITE; PS00455; AMP_BINDING; 3.
DR   PROSITE; PS50075; CARRIER; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031523};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1406..1481
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2476..2551
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3932..4006
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          427..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          584..625
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1386..1407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4493 AA;  483813 MW;  B2DCF17D32D320FF CRC64;
     MTMPLSAAQL GVWYAQQIDA ASPAYKIGEY LEIHGAIDVA LFERAVRGVC AGVDSLWIRI
     AETSGGPRQT VETERDWRLP VVDVSGEADP RAAAESWMRR ELARPVDLLG ERLFTHALFT
     VSEEKFYWFQ AYHHIVVDGY GFSLIARQVA KVYSDLLQGG PGDVGFPAFS ELLEEDSRYR
     SSKDFARDGE FWSSAFSDRP VPPRLAGRPE IRPRQVLRHT AYLDRDVVAR LRGVADKAGI
     RWSRLLIAAA AGYVHRGTGE RDVILGLPAL ARVTELSRRV PAMMSNILPL RVPVSPDTAL
     VDLAAEVSHR TREVLEHQRY RGEDLARRLA LRDDIRRYVG PVINITTFDY DIRFGDCRTT
     AHNMSAGLTD DMSFLLYDRP DPRGLRLDLD ANPTLYSASD LVRHEQRFGE LLSVMADDPH
     RKLGRVALTG TGGTGRAPQR AVTSAEGTGG PDKDEATAAA TLPELFQATA ARRPFALALD
     GGEQLTYAAL NARANRLARR LVAEGAGPER IVALILPRSP ELVVAQLAVA KAGAAYLSIE
     PGLPADRVRY LLADASPALL VSSAAVAADL ADEVRSRLLL MDDAVGPDRD DVPDPDGNKA
     SGSAPHPHPH SPPNPDADLT DAERRGPLTP SAPAYVIYTS GSTGRPKAVV VTHAGIAGLA
     AAQLEHFALT AEARVLQFAS PSFDASVMEV LMAFAAGAAL VVPPAGPLVG DALAEVLLRE
     RVTHALIPPT VWASVTGTAF PHLRTLVVGG EPCPPELVET WAGRLRLVNA YGPTESTACV
     TVSAPLSPGA APPLGHPLAH TGLYVLDPHL HPVDAGTSGE LYVSSTGLAR GYLGRAALTG
     ERFVADPYGA PGARMYRTGD LVRRRPDGNL EFLGRADDQV KIRGFRIEPG EVEATLSRHP
     GVARAAVVAR QEESGERRLV AYVVPRAEDG TARDAGQEDR HVDEWRSIYE SVYEGSEARG
     DRGFVTDFSG WNSSYDGRPL PVAQMEKWRA AAVEAIRALG PRRVLEIGIG SGLIVSQLAP
     ECEVYWGTDF SAAAVDTQRA RVAGLPELAG RVEFSCRPAH DTTGLPGDFD TVVVNSVAQY
     FPSADYLLDV VRKAVRLLRP GGRIFLGDIR NLRLLRTLHS AVELTRLETG ADPAGVSGRI
     DHALTVEKEL LVDPDFFAGL VGSVEGVDGV DIRLKRGDYH NELTRYRYEV VLHKSPDRPL
     RSLREVPVRR WSEVAGSGGS GGLDEIARLL ERERPACLRI SGIPNGRLVQ EASAARELRV
     SGSVRAALGH LSGEEAAVTA VDPEALHRLG AAQGYRVAAT WSARGADDCF DAVLVSGEAD
     REAPWTDTYL PAEGFTSAPL TNSPSSVDAG GELVHALHAY AREQLPGYLV PSAFVPMREL
     PWTSSGKLDR GALPAPEAHS SGRSRAPRTA QEEMLCHLFA EVLGRQEVGL DDDFFALGGH
     SLLATRLLTR VRSALGLDLP IRVFFDTPTV AALADRLGTA APARPALEPR PRPEDARLSF
     AQQRLWFLHR LEGESSTYTL PVAFRLHGPL DVRALDAALE DVVTRHESLR TLFEERDGDP
     RYRVLDPAEA AAALRLREVP TDEGALAEQL AEAAGEGFDL ATELPLRATL FRLGAQEHVL
     LLMLHHIAAD GWSLGPLQRD LGTAYAARRQ GGQPPWPPLR VQYADYADWQ RELLGDETEA
     DSLVSGQLTY WREQLSEVPA DLPLPADHPR PARATYRGRT VPLGIDPALY ARIRETARAH
     GVTEFMVVHA AVAALLTRTG SGTDIPIGTP VAGRTEEALD ELVGFFVNTL VLRTDTSGDP
     SFAQLLDRVR AVDLAAYAHQ DLPFERLVEA VRPARSLARQ PLVQVMLAFQ NVPAAGPELA
     GVRVEPQPVA TDFAKFDLTF HLNARPGTAH DPAELSGSLE YSTDLFTART AEALAARLVL
     LLRAATADPA RRLSGLDLFT REERQRLTAH RNPALADRPS ATLPELFAAQ VRRAPGAVAV
     SQGDHTLGYA ELDERANRLA HLLLDRGVGP ETPVALLMER TPDLVVAVLA VLKAGGVYVP
     IDPGYPAERV AFILADARPA CLIADTRPDQ AAAPGAACLA LDDPELRRQL ESAPATDPAR
     RVSPQNGAYL IYTSGSTGTP KGVLVTHANV VRLFDASSAF AFGPGDVWTL FHSYAFDFSV
     WEMWGALRYG GRLVVVPRPV ARSAEAFLDL LVRERVTVLN QTPSAFHQLV AAGREHTRLE
     RELALRAVVF GGEALDPARL AEWYERHGDG GPALVNMYGI TETTVHVTHW PLDAAKAVAG
     PSRIGVPLAD LDTYVLDGSL GQVPPGVAGE LYVSGGGLAR GYAARAALTA ERFVADPFGP
     PGSRMYRTGD VVRRNGAGEL EFLGRADTQV KLRGFRIELG EIEAALGAAP GVEQAVATVR
     EHGAGDRRLI AHVVLADGGR DTGGLRRHLA ERLPEFMVPS AFVAVDAFPL TANGKLDREA
     LPAPDAEPVA VGPRGRQHTA TEEILSGLFA EILGVASVGP EDDFFALGGH SLLATRLVSR
     IRSVLGVELP IHRLFDAPSV SRLIPHLDTA GRARPALRPG PRPEAVPLSF AQQRLWFIHQ
     LEGPTAAYHI PLGLRLTGPL DEAALSAALR DVTARHESLR TVFTAEGGRG RQLVLDTEEA
     YPRLETADVT EAELGERTAE VARRGFDLAA QPPLRAALFR LSAREHVLVV VLHHIAADGW
     SLAPLARDLA TAYEARCAGR EPGWAPLPVQ YADYTRWQRE VFGSEQDEDS LIGRQAAYWR
     AHLAGLPERL ALPADFPRPA EAGHRGDTVS FTVGPELHER LRAVAARHHV TLFMVLQAGL
     AALLTRTGSG TDIPIGSPVA GRTDEALDEL VGFFVNTLVL RTDTSGDPSF AELLERVRAV
     DLAAYAHQDL PFEQVVEMLN PERSLAQHSL FQVILALQNA PAAQLRLPSL EAAPEPVGLA
     AAKFDLFLSL AERPDGSGAP VGLDGTVEYR TDLFRAETVR ALVHRYLRFL DAVTEDPGRS
     LGSVDLVTEE ERRRLLAAGT GGTCAVPDGT LAEQFEAQAA RTPDAPALLT GAVPTTYAEL
     DARANRLAHW LIEAGVTPED PVALAMERTA EVVVAILAVL KAGGCYVPLD TRSPRVRTDR
     IVEQVGAALL LTDDPERHRR REHPARVVPL GELPLSGCPA TAPEVPGHGA RLACVMYTSG
     STGVPRGVAV TQRDVLALAG DTCWQGGDHE RVLMHSPHAF DASTYELWAP LLNGGTAVLL
     PPGEPDLAVL RRTITEGRVT ALWLTAGMFA LIAEESPECL DGLRQVWTGG DAVSPGAVRR
     VRARCPGLTV VDGYGPTEAT TFATRHLLRP EDAEHTIPIG RPMDSMRAYV LDERLRLVPP
     GVVGELYLAG TGVARGYLGR PGASAERFVA DPFGGPAGRM YRTGDLARWN ARDELEFRGR
     ADDQVKLRGF RIELGEVERA LSGTPGVGQA AAVVRQDGPG NKHLAAYVVP ASGDGSPGAG
     PEAEERVGQW HEIYEQLYGQ VAELTPGADF RGWNSSYDGN PIEPGQMREW QSATLDRIRE
     LRPRRVLEIG VGTGLLLARL APDCEAYWGT DLSETVIGTL RRAIAGDPGL RDRVTLRAQP
     ADVFTGLPTG FFDTVVINSV IQYFPGADYL TRVLRESVRL LAPGGAVFVG DVRNLRLQET
     FAGAVELARR GGPVDTEELR AAVRQAVAVE NELLVDPSFF CEFADEAPVG CADVRIKRGH
     HHNELTRYRY DVALHRAPVG GLRPADSLES VRWGREVAGL AALSDRLSGQ AGGLRVTRVP
     NARLAAEARA AAVVAPGGPD PSAAPDPEAF WELGARLGHQ VVASWSPDGD HGELDFLFLD
     AEESPDAPVV AYPPGEGSRA SARPRTNNPA RLAEREALVR AVLDRAPSVL PDYMVPATVV
     VLDRLPLTRN GKIDRAALPA TPAPRAAAGD QGAGTPEEEK LCELFARVLG LPAVGVQDSF
     FDLGGDSIVS IQLVSRARDA GLTITPRDIF QHKTVAALAA VARSRTERTA EAAGAGIGTV
     ELLPVAHWLR ERGGPVDEFE QNVLVRVPGG GDEAGLLAAL QALLDRHDAL RMRLGRDPWS
     LEVGPPGSIP ARACVQRIDT GGWAESAVRA AADEHVVRAR QQLAPEEGQL VRAVWFDAGP
     LRSGLLLLVV HHLAVDAVSW QILLPDLAKA WAATAAGEAP SLAPVGTSLR QWARRLAEEA
     VHSDRVAELP LWRKALEAPD PLLTDRPLDP ARDTGSRLRS LSLDLPTEVA APLLTSVPGV
     FHARINEVLL TAFAQAVAES RGLADTGVLL DLEGHGREEL DEESDLSRTV GWFTSIFPVR
     LDPGARGLTS GEAVNRVKEQ LRALPDNGLG FGLLRHLNPE TGPGLARLPR PQLGFNYLGR
     LPVSDGGDWT MVADRGAGSP AADLPAAHAL EVNAYAHERD GGSVLTARWT WPAELWPEAG
     VRSLADRWFE RLGRLVAEAA DPGAGSRTPS DLPLLSLSQE EIDMLETEWG TES
//