GenomeNet

Database: UniProt
Entry: A0A0B5EY37_STRA4
LinkDB: A0A0B5EY37_STRA4
Original site: A0A0B5EY37_STRA4 
ID   A0A0B5EY37_STRA4        Unreviewed;      4385 AA.
AC   A0A0B5EY37;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   SubName: Full=Type I modular polyketide synthase {ECO:0000313|EMBL:AJE87703.1};
GN   ORFNames=SLNWT_7327 {ECO:0000313|EMBL:AJE87703.1};
OS   Streptomyces albus (strain ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 /
OS   NBRC 107858).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1081613 {ECO:0000313|EMBL:AJE87703.1, ECO:0000313|Proteomes:UP000031523};
RN   [1] {ECO:0000313|EMBL:AJE87703.1, ECO:0000313|Proteomes:UP000031523}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 21838 / DSM 41398 / FERM P-419 / JCM 4703 / NBRC 107858
RC   {ECO:0000313|Proteomes:UP000031523};
RA   Lu C.;
RT   "Enhanced salinomycin production by adjusting the supply of polyketide
RT   extender units in Streptomyce albus DSM 41398.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP010519; AJE87703.1; -; Genomic_DNA.
DR   KEGG; sals:SLNWT_7327; -.
DR   Proteomes; UP000031523; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   CDD; cd08952; KR_1_SDR_x; 1.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR   CDD; cd00833; PKS; 3.
DR   Gene3D; 3.30.70.3290; -; 3.
DR   Gene3D; 3.40.47.10; -; 3.
DR   Gene3D; 3.40.50.11460; -; 1.
DR   Gene3D; 6.10.140.1830; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR041618; PKS_DE.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 3.
DR   Pfam; PF16197; KAsynt_C_assoc; 3.
DR   Pfam; PF00109; ketoacyl-synt; 3.
DR   Pfam; PF02801; Ketoacyl-synt_C; 3.
DR   Pfam; PF08659; KR; 2.
DR   Pfam; PF18369; PKS_DE; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 3.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 3.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00822; PKS_KR; 2.
DR   SMART; SM00825; PKS_KS; 3.
DR   SMART; SM00823; PKS_PP; 3.
DR   SMART; SM01294; PKS_PP_betabranch; 2.
DR   SUPFAM; SSF47336; ACP-like; 3.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR   SUPFAM; SSF53901; Thiolase-like; 3.
DR   PROSITE; PS50075; CARRIER; 3.
DR   PROSITE; PS00606; KS3_1; 2.
DR   PROSITE; PS52004; KS3_2; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031523};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          3..419
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          903..978
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          998..1424
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          2666..2741
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2761..3187
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          4230..4305
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1427..1449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4385 AA;  460145 MW;  120D411DD87D4093 CRC64;
     MRDEHIAVIG MACRVPGAST PDEFWQLLRE GVSAITEIPA DRHAAELEDA GIRFGGFLDA
     VDEFDPEFFG ISPREALAMD PQQRLALELC WEALESTGTD PAALRESRTG VFIGAIADDY
     AALARRERTS VTQHTLTGLN RGIIANRLSY ALGLRGPSVA VDTGQSSSLT AVHLACESLR
     RGESETAVAG GVQLNLAPDS FLAASAFGAL SPDGRCFTFD ARANGYVRGE GGGLVVLKRL
     ADAERDGDPV LCVIRGSQTN NDGGGDSLTT PARQGQESML RAACAQAGIA PGAVQYVELH
     GTGTRAGDPV EARALGEVLG AGRPAETPLR VGSVKTNVGH LEGAAGITGL IKTVLSLVHR
     ALPPSLNHES PHPAIPLDEL GLRVQTAHED WTPPTGLPRL AGISSFGMGG TNVHVVLEEA
     PGGETAEAAP ERPVPPRQVA WPLAGRSEAA LRAQAARLHT HLLSRPELHP LDVGYSLATS
     RTAFAHRAVL TGSDRDTLLA DLHHLASGTT PAATALHGRT AFLFTGQGAQ RLGMGQELYE
     TFPAFAAAFD AVCAELDQHL DVPVRDVVFG QDADALDRTV STQSALFALE VALFRLIESF
     GVAPDFVMGH SIGEISAAHI AGVFSLEDAA ALTAARGRLM QALPEGGAMV SLQLPEADLL
     PHLDGYEDRV SIAAINGPTA TVISGDEASV LEIAEATGAK TKRLRVSHAF HSPLMEPMLA
     EFGAVASSLT YRTPRIPVVS NVTGGLADEE IATPDYWVRH VRQAVRFADG IEELAAREVT
     RFVEVGPGGV LTAMAREGLP RTATDTGTDT GTGAAFVSLL RKDRPEAEAL FAALGQLHAH
     GGDLDWHKLY QGRGAQRVEL PTYAFQRRRY WLDSPLPGAA EEAAPVSWRD RYLALGEEAE
     RDRAALELVR AQTARVLGHD GPEAVPTEQV FKDLGFDSLM SVELCDLLST ATGSRLAGAV
     LFDHPTPAAL ARHVQQVVTG TRGARTARPV VRRSASAEEP IAIVAMSCRL PGGVRSPEEL
     WRLVSEGEDA IAAFPTGRGW DLEGLYDPDP GRHGTSYVRE GGFLYEADRF DAAFFGISPR
     EAQAMDPQQR LLLETAWEAF ERAGIDPAVL KGSEAGVFVG AMPQDYGPRM DEAAEGQEGY
     LLTGGTTSVA SGRIAYTFGL QGPAVTVDTA CSSSLVALHL ACQSLRQGEC TMALAGGATV
     MSSPGIFVEL SRQKALSPDG RCKAFSSDAD GTGWGEGVGM VLLERLSDAR RNGHQVLALV
     RGSATNQDGA SNGLTAPSGP AQQRVIRQAL ADAGLSGEEV DAVEAHGTGT SLGDPIEAGA
     LLATYGQDHS PQRPLWLGSL KSNVGHPQAA AGVAGVIKMV MALRHGVLPR TLHVREPSPH
     VDWSSGAVAL LTEAQAWPEA GRPRRAGVSS FGISGTNAHA ILEQAPLEPQ ESPEPKPEPQ
     APEQEQAEAA EAGAFVLPWV LSGRTEQALR ERAEQLLTHL SASPGTDPAD SESADAESAD
     ADLADVAFSL ATGRAAFDHR AALVGRDREE MLAGLAALAQ GGSAPQLAQG AGGGGRGAVF
     VFPGQGSQWI GMASALWDSS PVFAAQLEAC LEALEPFLDW SLRDVLRGEE GAPSLSRIDV
     VQPALFTVMV SLAALWRAHG VEPVAVVGHS QGEIAAAYVA GGLSLQDAAR VVARRSQAWY
     ELSGKGGMLS VLDSAEAVAE RLEQWSERLG IAAVNSPGAV TVSGDPEALD AFMAELSADG
     VKSRRIPGVD TAGHSPQVDA LRERLLREVA GVAPVASRIA YYSTVTGGAL ETTALTAEYW
     YRNMREPVDF ERTCRALLAD GHTAFVECSP HPMLALPLQQ TIEAAGADAV VVGTLRREEG
     GRERFAGAFA EAYAQGVRPE WGAVFAGRGA RRIALPTYPF QRQRYWLDKP VAAGEVAAAG
     LDAAGHPLLG AVVALAGGQE YLLTGRLLAQ GQPWLAEGAE SGTAVVPGSV FAELAVQAGD
     RCGCPRIDEL SLSAPLLLPA RGAVLLQVRV GAPDEQGRRD VSVHARAQGA DADEPWTAHA
     TAVLTTDGGA HVDAAGGEFG DGAAVWPPAG AVPVAGAVGA WRLGQEVFAE VALNEAESAE
     AAAYALHPVL LESVLAGLEL PDVPGGLRLA SQWRGLVLHA GGASALRVRL SPVGAGAFAL
     AAQDTEGRAV VTAESVTLRA LDEGELAGNS GRHPSLFRLG WPVLRAEGGQ EARLAVLGED
     TLALGAATGA QVFEESEQAP QAVLVPLTAG GDQVAEAAHE AAHRALALIQ RWIAEEQLAD
     TRLVFVTRGA LAAVEGEEVP DVAHAAVWGL VRSAQSEHPG RFVLVDLDGH PGSAPALRAA
     LASGEEQCAI RAGEIRVPRL ARTAANAEAA EAASRALDPE GTVLITGATG TLGGLLARHL
     VTVHGVRRLL LISRRGPAAE GMDELRTELG ASGATVTVAA CDAADREALA RLLAEIPAAH
     PLTGVFHAAG VLDDGVVDAL TPERLDAVLR PKADAAQNLH ELTAEADLAA FVLYSSVVAT
     IGNAGQANYA AANAFLDALA QHRRARGLSG QSLAWGLWEQ ASGMSGHLAE ADVQRMARSG
     VRPLPSTLGM ELFDAARTAG DATLVPVLLD LTELRRRAAG GETPPAWLRG LVHTPPRRLV
     RARTGQEQDT SFGATLAALA PAMRESFLLD LVREHAAAVL GLASPEDIAA GRAFREVGFD
     SLTAVELRNR LNAATGLRLP ATLLFDYPTP AVLVGHLRTE ALGEEAATVE VSAPVRGADA
     DDPIAIVAMS CRLPGGARTP EELWELVAEG RDVISGFPGD RGWDVEELYD PNPGTPGRSY
     AKEGGFLYDA YDFDADFFGI SPREALAMDP QQRLLLETSW EALERAGIDP HSTRGTAAGV
     FIGSTGQDYA SQLREIPEEM EGYLLTGKAA SVVSGRIAYS LGWEGPALTL DTACSSSLVA
     IHQAAQALRQ GECTLALAGG TTMMSTPSLF VEFSRQRGLA PDGRSKAFSS DTDGTSWGEG
     VSMVLLERLS DARRNGHEVL ALVRGSAVNQ DGASNGLTAP NGPSQQRVIR QALAHAGLSA
     DEVDAVEAHG TGTRLGDPIE AQAILATYGQ GRESERPLWL GALKSNIGHT QGAAGGAGVI
     KMVMAMRHGL LPRTLHVKAP TPHVDWSAGE VELLTEARPW PRSERVRRAG VSAFGISGTN
     AHLILEEAPP AEPVEVITPE EATTEEGSLN GASWPLTWPL SGHTAAALRA QAARLHTHLQ
     NRPELHPLDI GYSLATSRAA LDHRAVLVGT DREQLLAELG QLATGMTPGT TAQEGRTAFL
     FTGQGAQRLG MGAELYETFP VFAAAFDAVC AELDRHLDIP VRDVVFGQDA DALDRTVSTQ
     SGLFALEVAL YRLVESWGVA PDFVMGHSIG EIAAAHIAGV LSLEDAATLT AARGRLMQAL
     PQGGAMVSLQ LPEAEVLPHL EGFEDRVSIA AINGPASTVI SGDEASVLQI AEATGAKPKR
     LRVSHAFHSP LMEPMLAEFG KLAATLTYHT PHTPVVSNVT GTLADDDIAT PDYWVRHVRQ
     AVRFADGVRY LHGQDVARFV EVGPAGVLAA MARESLPDTG TGNGTGAGAG TGTGAGAAFV
     PLLRKDRPEA EALFAALGQL HAHGGDLDWH KLYQGRGAQR VELPTYAFQR KRYWFAAPEE
     TGSEAAAGAG SVEARFWDAV EREDLAELTA ALQVDERTRL GELVPALSSW RRGQSDRAVL
     DSWRYRVSWY PVADSGQSSL SGGWLVAVPA AQAASEPVEW ALSGLRERGA RVVPFPVAGQ
     EPAELAGRLR EAAAEGRFAG VLSLLALDET PYPEHPSLSA GLVGNLALVQ ALGEAGIAAP
     LWLATRGAVS VGPSDPLNGW TQAATWGMGR VVALEHPQRW GGLVDLGAHL DARAADRLCA
     ILSGLEGPSG VEDQLALRDG GVLVRRLVKA PVRDTGEKGF TPHGTVLITG GTGGLGAQVA
     RRLARGGAGH LVLTSRRGEA APGAAELREE LLALGADRVT VAACDMAERS EVAALIEQVT
     ADGEAVRAVF HAAGVVEFAQ LAQSAPADFA RMADGKVRGA GYLDELLDPE RLEAFVLFSS
     IAATWGSGGQ SAYAAANAQL DALAEHRRAR GLPATSVAWG PWADEGMIEQ GEVAEHLSRR
     GLPAMEPRLA VAALTEALEG RETSLVVADV RWERFVPGFT SARSRPLLGE LAEVRAVLAA
     PAAGESEWAE EEAHGFLEGL AGLPAQEVER ALRDLVHAQT AAVLGHSSPE VVATGRAFKE
     LGIDSLTSVE LRNRLGALTG LELPATLVFD YPAPAPLAGY LREELLRGRP DEALSVFEDL
     DKWESALPEL LADEAVRDRL AGRLHALVAK LGAPPEQGAG SVDSSLISAT ADEVFDFIDN
     EFGAS
//
DBGET integrated database retrieval system